Anti-centromere antibodies in routine use

Sabrina MEJDOUB, Lalla Mariem Cheikh Hamza (Autoren)

Buch | Softcover

52 Seiten

2024
International Book Market Service Ltd (Verlag)
9786203500295 (ISBN)

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Anti-centromere antibodies (ACA) can be detected by indirect immunofluorescence (IFI) or immunodot (ID). Our aim was to assess IFI/ID concordance and the clinical relevance of ACA.Patients presenting with ACA positivity by IFI on Hep-2 cells and/or by ID were included. ACAs were detected in 63 cases (2.1% of IFI+ID tests). ACAs were positive by IFI and ID in 18 cases. Discordances involved 2 cases of ACA-IFI+/ACA-ID- and 43 cases of ACA-IFI-/ACA-ID+. For these 43 cases, the nuclear fluorescence appearance (IFI) was speckled (34), nucleolar speckled (6) or homogeneous (3); ACA (ID) was weakly positive (26), positive (7) or strongly positive (10).The diagnosis of connective tissue disease (systemic scleroderma, systemic lupus erythematosus, rheumatoid arthritis) was retained in 3 patients out of 18 with clinical information. IFI on Hep-2 cells has certain limitations (operator-dependent; one fluorescence appearance may be masked by another). ID is useful for confirming antigenic specificity, within the limits of the antigens used. Interpretation of these tests depends on the clinical context.

Dr Sabrina MEJDOUB, Specialist in Medical Biology, Immunology option. University hospital assistant at the Immunology Laboratory of the Habib Bourguiba University Hospital (Sfax, Tunisia).

Erscheinungsdatum	21.12.2024
Verlagsort	Beau Bassin
Sprache	englisch
Maße	152 x 229 mm
Gewicht	91 g
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
Schlagworte	anti-centromere antibodies • immunodot • immunofluorescence
ISBN-13	9786203500295 / 9786203500295
Zustand	Neuware