Genomics-Guided Natural Products Discovery

Buch | Hardcover

470 Seiten

2025
Academic Press Inc (Verlag)
978-0-443-34527-2 (ISBN)

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Genomics-Guided Natural Products Discovery, Volume 717 focuses on how the genomics revolution has catalyzed a resurgence of interest in natural products research. With the explosion of new sequencing data to analyze, “genome-mining” tools have grown in sophistication. Hence, this volume captures the utility of these tools, serving as a how-to guide to lower the entry barrier for newcomers. Topics covered in this new release include Merging RODEO with genomic enzymology workflows to guide RiPP discovery, Exploring Ribosomally Synthesized and Post-translationally Modified Peptides through SPECO-Based Genome Mining, Genome Mining for Natural Products Made by Multinuclear Iron-dependent Oxidation Enzymes (MNIOs), and much more.

Additional sections explore Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases, Global genome mining in fungi using FunBGCe, Plant genome mining of burpitides from fused precursor peptides, Determining biosynthetic gene cluster boundaries thru comparative bioinformatics, Genome mining for bacterial terpenoids, Bioinformatics guided synthesis of natural product cyclic peptides, Overview of Genome Mining Strategies for Natural Products Discovery, and much more.

Doug Mitchell holds the Warren Professorship in the Department of Biochemistry at Vanderbilt University and serves as Director of the Vanderbilt Institute for Chemical Biology. He also holds an appointment in the Department of Chemistry. Mitchell received a BS in Chemistry from Carnegie Mellon University, PhD in Chemistry from UC Berkeley (Marletta), and completed postdoctoral work at UC San Diego (Dixon). Mitchell joined the Department of Chemistry at the University of Illinois at Urbana-Champaign faculty in 2009 with promotion to Associate Professor in 2015 and Professor in 2018. In 2019, Mitchell co-founded Lassogen, Inc. (San Diego), which is developing lasso peptides as a new modality for treating cancer. In 2024, he moved to his current position at Vanderbilt. Mitchell’s research centers on the chemical biology of natural product biosynthesis, and derives insights from big data genomics, mechanistic enzymology, and synthetic biology. Edit

1. Merging RODEO with genomic enzymology workflows to guide RiPP discovery
Graham Arthur Hudson
2. Exploring Ribosomally Synthesized and Post-translationally Modified Peptides through SPECO-Based Genome Mining
Yongxin LI
3. Genome Mining for Natural Products Made by Multinuclear Iron-dependent Oxidation Enzymes (MNIOs)
Wilfred van der Donk
4. Genome-based discovery of polyketides generated by trans-acyltransferase polyketide synthases
Piel Jörn
5. Global genome mining in fungi using FunBGCe
Yudai Matsuda
6. Plant genome mining of burpitides from fused precursor peptides
Roland Kersten, Lisa S. Mydy, Derrick A. Ousley and Xiaofeng Wang
7. Determining biosynthetic gene cluster boundaries thru comparative bioinformatics
Kou-San Ju
8. Genome mining for bacterial terpenoids
Jeffrey Rudolf
9. Bioinformatics guided synthesis of natural product cyclic peptides
Elizabeth Ivy Parkinson
10. Overview of Genome Mining Strategies for Natural Products Discovery
Marc Chevrette
11. TBD
Grace Kenney
12. Cyclophane-forming radical SAM enzymes: Heterologous expression and characterization of products
Brandon Morinaka
13. New algorithms for connecting mass spectrometry to genome mining
Hosein Mohimani
14. TBD
Hengqian Ren
15. Membrane vesicle activation of silent bacterial metabolites
Aya Yoshimura
16. TBD
Agarwal Vinayak
17. Mining Microbial Genomes with the antiSMASH Suite of Tools
Kai Blin

Erscheinungsdatum	03.07.2025
Reihe/Serie	Methods in Enzymology
Verlagsort	San Diego
Sprache	englisch
Maße	152 x 229 mm
Gewicht	450 g
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-443-34527-9 / 0443345279
ISBN-13	978-0-443-34527-2 / 9780443345272
Zustand	Neuware