Targeted Protein Degradation Technologies
Academic Press Inc (Verlag)
978-0-443-21816-3 (ISBN)
This book serves as an invaluable resource for researchers and professionals in molecular biology, cell biology, and related disciplines, particularly those involved in protein degradation and the development of novel therapeutic strategies.
Dr. Jiangjiang Qin is currently a Professor of Cancer Pharmacology and Drug Discovery at the Institute of Basic Medicine and Cancer (IBMC), and the Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital). He received his PhD in Biomedical Engineering with the highest honor from Shanghai Jiao Tong University, China before completing postdoctoral training in cancer biology, pharmacology, and molecular therapeutics at Texas Tech University Health Sciences Center (TTUHSC). Following this he was appointed as Senior Research Associate at the university. Dr. Qin’s research mainly focuses on the discovery and development of novel, effective, and safe anticancer agents as well as demonstrating the molecular targets and mechanisms of action. He has published more than 120 research papers and reviews. He is an Associate Editor of Frontiers in Pharmacology and Frontiers in Oncology and an editorial board member of more than 10 scientific journals. Dr. Xin Luan received his B.Sc. in Pharmaceutics from China Pharmaceutical University (2011) and was awarded his PhD degree in Pharmacology at Shanghai Jiao Tong University (2016). He subsequently worked for two years as post-doctor at the University of Michigan under the guidance of Professor Duxin Sun. In 2018, he joined Shanghai University of Traditional Chinese Medicine (SHUTCM), and is currently appointed as a professor. He is currently working on anti-tumor pharmacology and delivery systems of natural products. Dr. Luan has published more than 60 research papers and reviews. Dr. Weidong Zhang obtained his BSc and Master degree in Natural Medicinal Chemistry from the Second Military Medical University in 1988 and 1991, respectively. He received his PhD in Natural Medicinal Chemistry from the Shanghai Institute of Pharmaceutical Industry (1998), under the supervision of Professor HuiTing Li. He is currently a professor of the Shanghai University of Traditional Chinese Medicine and Second Military Medical University. His research mainly focuses on Chinese medicine formulas, isolation, structural identification and modification, total synthesis, and structure–activity relationships of bioactive natural products. Dr. Zhang has published more than 500 peer-reviewed research papers and reviews.
Part 1: Introduction
1. Mechanisms of protein degradation
2. Overview of targeted protein degradation
Part 2: Summary of targeted protein degradation
3. Protease-mediate degradation
4. PROTAC
5. AbTAC
6. Molecular glues
7. Hydrophobic tagging technology
8. Lysosome-mediate degradation
9. LYTACs
10. Bispecific Apt amer Chimera (BIAC)
11. GlueTAC
12. AUTACs
13. ATTECs
14. AUTOTAC
Part 3: Degradation of Proteins of Interest
15. Degraders of signal transduction receptors
16. Degraders of membrane-associated proteins
17. Degraders of cell cycle- and anti-apoptosis-related proteins
18. Degraders of proteins in epigenetic regulation
19. Degraders of proteins involved in transcription nuclear hormone receptors
20. Transcription factor degraders
Part 4: Clinical applications of targeted protein degradation
21. Clinical development of protein degraders
| Erscheinungsdatum | 02.08.2025 |
|---|---|
| Verlagsort | San Diego |
| Sprache | englisch |
| Maße | 191 x 235 mm |
| Gewicht | 840 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie |
| ISBN-10 | 0-443-21816-1 / 0443218161 |
| ISBN-13 | 978-0-443-21816-3 / 9780443218163 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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