Schizophrenia

Methods and Protocols

Leyre Urigüen, Rebeca Díez-Alarcia (Herausgeber)

Buch | Hardcover

155 Seiten

2023 | 2023 ed.
Humana (Verlag)
978-1-0716-3306-9 (ISBN)

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This volumes presents current methods used in the research of schizophrenia. Chapters guide readers through molecular techniques, in vivo approaches, cell cultures and heterologous expression systems, and even research methods involving human studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Schizophrenia: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.

A Novel Method to Estimate Levels of Receptors Using an Allosteric Modulator. Focus on muscarinic M1 receptors.- Enhanced bystander BRET (ebBRET) biosensors as biophysical tools to map the signaling profile of neuropsychiatric drugs targeting GPCR.- [35S]GTPγS (Guanosine-5′-O-(γ-thio)triphosphate-[35S]) Binding Scintillation Proximity Assay experiments in postmortem brain tissue.- CRISPR/Cas9 as a simple technique for the generation of murine knockout models for neuropsychiatric diseasesEvaluation of sensory-motor gating deficits in mice th.- rough prepulse inhibition (PPI) of the startle response.- Automated detection of psychedelic-induced head twitch response in mice.- Gastrointestinal and microbiome profiling in rodent models of neurological and psychiatric disorders.- Electroencephalography for the study of the auditory P300 evoked potential and derived measurements.- Quantification of endocannabinoids in human plasma.- Neuropsychological and functional assessment of cognitive impairments in schizophrenia.- Clinical management and assessment of the early stages of psychosis: a multidimensional approach.

Erscheinungsdatum	21.07.2023
Reihe/Serie	Methods in Molecular Biology
Zusatzinfo	19 Illustrations, color; 6 Illustrations, black and white
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	Animal Models • Complex psychiatric disorders • heterologous expression systems • Neurobiology • Neurotransmission systems • Therapeutic Strategies
ISBN-10	1-0716-3306-6 / 1071633066
ISBN-13	978-1-0716-3306-9 / 9781071633069
Zustand	Neuware