Essentials of Carbohydrate Chemistry and Biochemistry
Wiley-VCH (Verlag)
9783527350636 (ISBN)
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Thisbe Lindhorst is full professor at the Faculty of Mathematics and Natural Science of Christiana Albertina University of Kiel (Germany). She studied chemistry at the Universities of München and Münster, received her diploma in chemistry/biochemistry in 1988 and her Ph.D. in Organic Chemistry in 1991 at the University of Hamburg. After a postdoctoral stay at the University of British Columbia she became Private Docent in 1998 at the University of Hamburg. Since 2000 she holds a chair in Organic and Biological Chemistry in Kiel. Her scientific interests are in the field of synthetic organic chemistry and in biological chemistry, especially in glycochemistry and glycobiology. Current research is focussed on the study of glycosylated surfaces and control of cell adhesion. She is the author of over 150 publications and of the textbook "Essentials in Carbohydrate Chemistry and Biochemistry". She has been an elected member of the DFG Forschungsforum from 2008 to 2016 and served as elected president of the German Chemical Society (GDCh) in 2016-2017.
1. Introduction
2. Structure of saccharides
2.1 Structure of monosaccharides
2.2 Structure of simple oligosaccharides
2.3 Structure of polysaccharides
2.4 Conformational analysis of saccharides
Chapter summary
Exercises and problems
3 Protecting groups for carbohydrates
3.1 Protection of the anomeric center
3.2 Acyl protecting groups
3.3 Ether protecting groups
3.4 Acetal protecting groups
3.5 Orthoesters as protecting groups
3.6 N-Protection for amino sugars
3.7 Enzymes in protecting group chemistry
3.8 Carbohydrate scaffolds and orthogonality of protecting groups
3.9 Protecting group patterns for allyl alpha-D-mannosides
Chapter summary
Exercises and problems
4. Important modifications and functionalizations of the sugar ring
4.1 Activation-substitution reactions at the carbohydrate ring
4.2 Deoxyhalo derivatives
4.3 Synthesis and reactions of anhydro sugars
4.4 Deoxygenation of carbohydrates
4.5 Functionalization at the anomeric center
4.6 Unsaturated saccharides -
Glycals
4.7 Epimerizations
4.8 Carbohydrates as chiral pool materials
Chapter summary
Exercises and problems
5 O-Glycoside synthesis
5.1 1,2-trans Glycosidation
5.2 1,2-cis Glycosidation
5.3 Participation of the solvent
5.4 The Koenigs-Knorr method
5.5 The trichloroacetimidate method
5.6 Thioglycosides
5.7 n-Pentenyl glycosides
5.8 Synthesis of 2-deoxy glycosides
5.9 Synthesis of beta-mannopyranosides
5.10 Synthesis of 2-deoxy-2-acetamido-glycopyranosides
5.11 Synthesis of glycopeptides
5.12 Solid phase oligosaccharide synthesis
5.13 Glycoside synthesis employing enzymes
5.14 Glycosylation strategies
Chapter summary
Exercises and problems
6 Structure and biosynthesis of glycoconjugates
6.1 Structural diversity of oligosaccharides
6.2 Structures of glycoconjugates
6.3 Biosynthesis of oligosaccharides
6.4 Biosynthesis of N-glycoproteins
6.5 Biosynthesis of O-glycoproteins
6.6 Biosynthesis of glycosphingolipids
Chapter summary
Exercises and problems
7. Glycobiology
7.1 Essentials of Glycobiology
7.2 Blood group specificities
7.3 Lectins
7.4 Oligosaccharide epitopes critical in cell biology
7.5 Understanding of the molecular interactions of the glycocalyx
7.6 Biochemical engineering
7.7 Metabolic oligosaccharide engineering
7.9 Microbial adhesion
7.10 Carbohydrate drugs
Chapter summary
Exercises and problems
8. Glycoarrays and Glycomimetics
8.1 Glycoarrays
8.2 Glycomimetics
8.3 Bacterial Anti-adhesives
Chapter summary
Exercises and problems
| Erscheinungsdatum | 09.11.2024 |
|---|---|
| Verlagsort | Berlin |
| Sprache | englisch |
| Maße | 170 x 244 mm |
| Themenwelt | Naturwissenschaften ► Biologie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Schlagworte | Biochemie • biochemistry • Biomolecules (DNA, RNA, Peptides, etc.) • Biomoleküle (DNA, RNA, Peptide) • bioorganic chemistry • bioorganische Chemie • Biowissenschaften • Chemie • Chemistry • Food chemistry • Food Science & Technology • Lebensmittelchemie • Lebensmittelforschung u. -technologie • Life Sciences |
| ISBN-13 | 9783527350636 / 9783527350636 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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