Kopplung von Peptiden an Oligoribonukleotide ohne Schutzgruppen

Maximilian Räuchle (Autor)

Buch | Softcover

182 Seiten

2021
Dr. Hut (Verlag)
978-3-8439-4866-1 (ISBN)

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Peptido RNAs are 5'-phosphorylated oligoribonucleotides connected to the a-amino group of a peptide via a phosphoramidate linkage. Previously, peptido RNAs with statistical chain length distributions could be detected as products of spontaneous reactions between amino acids and ribonucleotides in an aqueous condensation buffer. Although occupying a niche role in today’s biochemistry, the formation of peptido RNAs as possible intermediate evolutionary species may be important in relation to the molecular origin of life. To enable in- depth biophysical studies of these modified RNAs, synthetic protocols for obtaining monodisperse, pure compounds are described in this dissertation.

Erscheinungsdatum	28.09.2021
Reihe/Serie	Organische Chemie
Verlagsort	München
Sprache	deutsch
Maße	148 x 210 mm
Gewicht	283 g
Themenwelt	Naturwissenschaften ► Chemie ► Organische Chemie
Schlagworte	Oligonukleotide • Organokatalyse • Peptide
ISBN-10	3-8439-4866-6 / 3843948666
ISBN-13	978-3-8439-4866-1 / 9783843948661
Zustand	Neuware