The Design of Covalent-Based Inhibitors

Richard A Ward, Neil Grimster (Herausgeber)

Buch | Hardcover

298 Seiten

2021
Academic Press Inc (Verlag)
978-0-12-821689-7 (ISBN)

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Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Richard A. Ward is at AstraZeneca, UK Neil Grimster is at AstraZeneca, USA

Preface
Richard Andrew Ward and Neil Grimster
1. The history of covalent inhibitors
Renato A. Bauer
2. Kinetic Mechanisms of Covalent Inhibition
Claire Louise McWhirter
3. Covalent Drugs in Development for Immune-Mediated Diseases
Leonard Sung
4. Chemistry Perspectives of Reversible Covalent Drugs
Jianmin Gao
5. Design of Next-Generation Covalent Inhibitors: Targeting Residues Beyond Cysteine
Lyn Jones
6. Boron and Covalent Inhibition
Andrew Leach
7. Measuring and predicting warhead and residue reactivity
Christopher Rowley
8. Computational Support of Structure-based Targeted Covalent Inhibitor Design
Robert Abel
9. Novel approaches to covalent inhibition
Nir London
10. The future of covalent inhibition
Gyorgy M. Keseru

Erscheinungsdatum	16.07.2021
Reihe/Serie	Annual Reports in Medicinal Chemistry
Verlagsort	San Diego
Sprache	englisch
Maße	152 x 229 mm
Gewicht	610 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
Themenwelt	Naturwissenschaften ► Chemie
ISBN-10	0-12-821689-1 / 0128216891
ISBN-13	978-0-12-821689-7 / 9780128216897
Zustand	Neuware