Peroxisomes: Biogenesis, Function, and Role in Human Disease

Tsuneo Imanaka, Nobuyuki Shimozawa (Herausgeber)

Buch | Softcover

279 Seiten

2021 | 2019 ed.
Springer Verlag, Singapore
978-981-15-1171-4 (ISBN)

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This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given itsscope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.

Tsuneo Imanka, Faculty of Pharmaceutical Sciences, Hiroshima International University, JapanNobuyuki Shimozawa, Division of Genomics Research, Life Science Research Center, Gifu University, Japan

Part 1 Biogenesis and Function of peroxisome.- 1 The history of peroxisomal research.- 2 Peroxisome Biogenesis.- 3 Peroxisome Degradation and Its Molecular Machinery.- 4 The function of the peroxisome.- Part 2 Dysfunction of Peroxisome and Human Disease.- 5 Peroxisomal disorders.- 6 Model organisms used to understand peroxisomal disorders.- 7 Diagnosis of peroxisomal disorders.- 8 Therapeutic strategies for X-linked adrenoleukodystrophy, a representative peroxisome disease.- Part 3 Topics in Peroxisome Research.- 9 The isolation of peroxisomes.- 10 Structure Biology of peroxisomal proteins, peroxins.- 11 Lipidomics of peroxisomal disorders.- 12 Neurophysiology and neuropsychology for X-ALD.

Erscheinungsdatum	22.01.2021
Zusatzinfo	33 Illustrations, color; 32 Illustrations, black and white; XII, 279 p. 65 illus., 33 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Biologie ► Zoologie
Schlagworte	ABC Transporter • Biogenesis of peroxisome • Function of peroxisome • Lipid metabolism • Peroxisomal disorders • Peroxisome • PEX gene • Solute transporter • Very long chain fatty acid • X-linked adrenoleukodystophy
ISBN-10	981-15-1171-3 / 9811511713
ISBN-13	978-981-15-1171-4 / 9789811511714
Zustand	Neuware