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Glucuronidation of Drugs and Other Compounds

(Autor)

Buch | Softcover
268 Seiten
2020
CRC Press (Verlag)
978-0-367-20921-6 (ISBN)
CHF 87,20 inkl. MwSt
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Published in 1980: In a previous publication on glucuronic acid both free and conjugated, the author expressed the hope that glucuronic acid studies over the following few years might expand vigorously. The have expanded, and none more vigorously that the study of biosynthesis of simple glucuronides.

G. J. Dutton is Professor of Pharmacological Biochemistry in the University of Dundee, Scotland.

Part 1: Glucuronidation, Glucuronides and Studies on Udpglucuronlytransferase In Vitro 1. Introduction – The Biological Function of Gluuronidation 2. Structure and Properties of Gucuronides 3. Mechanism of Glucuronidation 4. Location of UDPGlucuronlytransferase in the Cell 5. Factors Affecting UDPGlucuronyltransferase Activity In Vitro 6. Purification of UDPGlucuronlytransferase and its Heterogeneity 7. Acceptor Substrates of UDPGlucuronyltransferase and their Assay 8. Enzymic Mechanism of Glucuronyl Transferase by UDPGlucuronyltransferase 9. Metabolic Pathways Immediately Preceding and Succeeding Glucuronidation – Anabolic Pathways Part 2: Factors Affecting Glucuronidation In Vivo 10. The Effect of Age on Glucuronidation 11. The Influence of Diet Glucuronidation 12. The Influence of Sex, Species, and Strain on Glucuronidation 13. The Influence of Hormones and Xenobiotics on Gluronidation 14. Extrahepatic Gluruonidation 15. Glucuronidation in Cultured Tissue and in Pathological Conditions 16. Relation of other Drug-Metabolizing to Glucuronidation Part 3: Practical Aspects 17. Principles of Assay Glucuronidation in Biological Tissues or Fluids and Selected Practical Procedures

Erscheinungsdatum
Reihe/Serie Routledge Revivals
Verlagsort London
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Studium 1. Studienabschnitt (Vorklinik)
Naturwissenschaften Biologie Biochemie
ISBN-10 0-367-20921-7 / 0367209217
ISBN-13 978-0-367-20921-6 / 9780367209216
Zustand Neuware
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