Biochemistry
John Wiley & Sons Inc (Verlag)
978-1-119-61055-7 (ISBN)
An integrated, skill-focused approach to the study of biochemistry and metabolism
Biochemistry integrates subjects of interest to undergraduates majoring in premed, biochemistry, life science, and beyond, while preserving a chemical perspective. Respected biochemistry educator John Tansey takes a unique approach to the subject matter, emphasizing problem solving and critical thinking over rote memorization. Key concepts such as metabolism, are introduced and then revisited and cross-referenced throughout the text to establish pattern recognition and help students commit their new knowledge to long-term memory.
As part of WileyPLUS, Biochemistry includes access to video walkthroughs of worked problems, interactive elements, and expanded end-of-chapter problems with a wide range of subject matter and difficulty. Students will have access to both qualitative and quantitative worked problems, and videos model the biochemical reasoning students will need to master. This approach helps students learn to analyze data and make critical assessments of experiments—key skills for success across scientific disciplines.
Introduces students in scientific majors to the basics of biochemistry and metabolism
Integrates and synthesizes topics throughout the text, allowing students to learn through repetition and pattern recognition
Emphasizes problem solving and reasoning skills essential to life sciences, including data analysis and research assessment
Provides access to video walkthroughs of worked problems, interactive features, and additional study material through WileyPLUS
This volume covers DNA, RNA, gene regulation, synthetic proteins, omics, plant biochemistry, and more. With this text, students studying a range of disciplines are empowered to develop a lasting foundation in biochemistry and metabolism that will serve them as they advance through their careers.
1 The Chemical Foundations of Biochemistry 1
Chemistry in Context 1
1.1 General Chemical Principles 2
1.2 Fundamental Concepts of Organic Chemistry 11
1.3 The Chemistry of Water 15
2 Nucleic Acids 26
Nucleic Acids in Context 26
2.1 Nucleic Acids Have Distinct Structures 27
2.2 Nucleic Acids Have Many Cellular Functions 37
2.3 The Manipulation of Nucleic Acids Has Transformed Biochemistry 45
3 Proteins I: An Introduction to Protein Structure and Function 67
Proteins in Context 67
3.1 Amino Acid Chemistry 69
3.2 Proteins Are Polymers of Amino Acids 74
3.3 Proteins Are Molecules of Defined Shape and Structure 79
3.4 Examples of Protein Structures and Functions 89
4 Proteins II: Enzymes 101
Enzymes in Context 101
4.1 Regarding Enzymes 103
4.2 Enzymes Increase Reaction Rate 108
4.3 The Mechanism of an Enzyme Can Be Deduced from Structural, Kinetic, and Spectral Data 117
4.4 Examples of Enzyme Regulation 127
5 Membranes and an Introduction to Signal Transduction 138
Biochemistry in Context 138
5.1 Membrane Structure and Function 139
5.2 Signal Transduction 149
6 Carbohydrates I: Mono- and Disaccharides, Glycolysis, Gluconeogenesis, and the Fates of Pyruvate 161
Carbohydrates in Context 161
6.1 Properties, Nomenclature, and Biological Functions of Monosaccharides 163
6.2 Properties, Nomenclature, and Biological Functions of Complex Carbohydrates 170
6.3 Glycolysis and an Introduction to Metabolic Pathways 177
6.4 Gluconeogenesis 193
6.5 The Fates of Pyruvate 196
7 The Common Catabolic Pathway: Citric Acid Cycle, the Electron Transport Chain, and ATP Biosynthesis 209
Electron Transport in Context 209
7.1 The Citric Acid Cycle 211
7.2 The Electron Transport Chain 223
7.3 ATP Biosynthesis 241
8 Carbohydrates II: Glycogen Metabolism, the Pentose Phosphate Pathway, Glycoconjugates, and Extracellular Matrices 253
Polysaccharides in Context 253
8.1 Glycogen Metabolism 255
8.2 The Pentose Phosphate Pathway 264
8.3 Carbohydrates in Glycoconjugates 273
8.4 Extracellular Matrices and Biofilms 284
9 Lipids I: Fatty Acids, Steroids, and Eicosanoids; Beta-Oxidation and Fatty Acid Biosynthesis 300
Lipids in Context 300
9.1 Properties, Nomenclature, and Biological Functions of Lipid Molecules 302
9.2 Fatty Acid Catabolism 311
9.3 Fatty Acid Biosynthesis 317
9.4 Ketone Body Metabolism 329
9.5 Steroid Metabolism 332
9.6 Eicosanoid and Endocannabinoid Metabolism 339
10 Lipids II: Metabolism and Transport of Complex Lipids 351
Complex Lipids in Context 351
10.1 Phospholipid Metabolism 353
10.2 Digestion of Triacylglycerols 361
10.3 Transport of Lipids in the Circulation 367
10.4 Entry of Lipids into the Cell 377
10.5 Neutral Lipid Biosynthesis 380
10.6 Lipid Storage Droplets, Fat Storage, and Mobilization 384
10.7 Lipid Rafts as a Biochemical Entity 388
11 Amino Acid and Amine Metabolism 397
Amine Metabolism in Context 397
11.1 Digestion of Proteins 399
11.2 Transamination and Oxidative Deamination 404
11.3 The Urea Cycle 409
11.4 Pathways of Amino Acid Carbon Skeleton Scavenging 414
11.5 The Detoxification of Other Amines and Xenobiotics 423
11.6 The Biochemistry of Renal Function 429
12 Regulation and Integration of Metabolism 440
Metabolism in Context 440
12.1 A Review of the Pathways and Crossroads of Metabolism 442
12.2 Organ Specialization and Metabolic States 446
12.3 Communication between Organs 455
12.4 Metabolic Disease 463
13 Nucleotide and Deoxynucleotide Metabolism 477
Nucleotides and Deoxynucleotides in Context 477
13.1 Purine Biosynthesis 478
13.2 Pyrimidine Biosynthesis 484
13.3 Deoxyribonucleotide Biosynthesis 489
13.4 Catabolism of Nucleotides 495
14 DNA Replication, Damage, and Repair 506
DNA in Context 506
14.1 Challenges of DNA Replication 507
14.2 DNA Replication in Prokaryotes 512
14.3 DNA Replication in Eukaryotes 517
14.4 DNA Damage and Repair 523
14.5 Homologous Recombination 534
15 RNA Synthesis and Processing 546
RNA Synthesis in Context 546
15.1 Transcription: RNA Synthesis 548
15.2 Processing of Nascent Eukaryotic RNA Messages 557
15.3 RNA Export from the Nucleus 566
16 Protein Synthesis 576
Protein Synthesis in Context 576
16.1 The Genetic Code 577
16.2 RNA Structure Function in Protein Biosynthesis 580
16.3 Protein Biosynthesis 585
17 Control and Regulation of Gene Expression 606
Gene Regulation in Context 606
17.1 DNA–Protein Interactions 607
17.2 Regulation of Expression in Prokaryotes 613
17.3 Regulation of Expression in Eukaryotes 623
18 Determination of Macromolecular Structure 649
Macromolecular Structure in Context 649
18.1 An Introduction to Structure Determination 650
18.2 Electron Microscopy 654
18.3 X-Ray Diffraction and Neutron Scattering 658
18.4 Nuclear Magnetic Resonance 668
19 Allosterism and Receptor–Ligand Interactions 679
Allosterism in Context 679
19.1 Allosterism and Cooperativity 680
19.2 Hemoglobin 686
19.3 Receptor–Ligand Interactions 696
20 Designer Proteins and Protein Folding 706
Protein Engineering and Folding in Context 706
20.1 Protein Production 707
20.2 Protein Engineering 714
20.3 Protein Folding 724
21 Biomolecule Purification 736
Protein Purification in Context 736
21.1 Protein Purification Basics 737
21.2 Size-Exclusion Chromatography 745
21.3 Affinity Chromatography 751
22 Bioinformatics and Omics 764
Bioinformatics in Context 764
22.1 Introduction to Bioinformatics 765
22.2 Generating Bioinformatic Data 769
22.3 Analyzing Bioinformatic Data 778
23 Signal Transduction 790
Cell Signaling in Context 790
23.1 A Review of Signal Transduction 791
23.2 An Overview of Regulation of Signal Transduction 797
23.3 Six New Signal Transduction Pathways 800
24 Protein Trafficking 821
Protein Trafficking in Context 821
24.1 Molecular Aspects of Protein Trafficking 822
24.2 Molecular Motors 827
24.3 Vesicular Fusion 834
25 Photosynthesis and Nitrogen Fixation 841
Photosynthesis and Nitrogen Fixation in Context 841
25.1 Photosynthesis 842
25.2 Nitrogen Fixation 859
Techniques T-1
solutions A-1
Glossary G-1
Index I-1
| Erscheinungsdatum | 11.08.2020 |
|---|---|
| Verlagsort | New York |
| Sprache | englisch |
| Maße | 213 x 277 mm |
| Gewicht | 1882 g |
| Themenwelt | Medizin / Pharmazie ► Studium ► 1. Studienabschnitt (Vorklinik) |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Chemie | |
| ISBN-10 | 1-119-61055-9 / 1119610559 |
| ISBN-13 | 978-1-119-61055-7 / 9781119610557 |
| Zustand | Neuware |
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