Ribozymes – Principles, Methods, Applications

S Müller (Autor)

Software / Digital Media

944 Seiten

2021
Wiley-VCH Verlag GmbH (Hersteller)
978-3-527-81452-7 (ISBN)

Infos

This all-encompassing reference on ribozymes integrates the knowledge that has gained in the field over the past 35 years, with contributions by virtually all leading experts in the field. Organized in seven major parts, it describes general principles and strategies of nucleic acid catalysis, introduces naturally occurring ribozymes including the search for new catalytic motifs or novel genomic locations of known motifs, followed by a part on artificial ribozymes developed by in vitro selection (SELEX). The fourth covers DNAzymes, their development and potential application. Engineering of allosteric ribozymes for artificial regulation of gene expression, the design of ribozymes and DNAzymes for medicinal and environmental diagnostics and as therapeutic tools are covered in parts 5 and 6. The final part looks at tools and methods in ribozyme research, including the techniques and assays for structural and functional characterization of nucleic acid catalysts.

Autor

Sabine Muller is Full Professor for Biochemistry/Bioorganic Chemistry at Greifswald University (Germany). Having obtained her academic degrees from Humboldt University Berlin, she spent one and a half years as a postdoc at the MRC in Cambridge (UK) and then took up a group leader position again at Humboldt University. After finishing her Habilitation in 2003, she moved to the Ruhr University Bochum, where she was a Professor for Bioorganic Chemistry, before taking up her present appointment at Greifswald in 2006. Professor Muller has received several scientific awards, including a Heisenbergstipendium of the Deutsche Forschungsgemeinschaft (DFG). She is a member of the Leibniz-Societat der Wissenschaften zu Berlin and of AcademiaNet. Benoit Masquida is a research director at Centre National de la Recherche Scientifique. After graduating from Universite Louis Pasteur in Strasbourg (France) working on the rules governing RNA folding, he spent one year at Yale University concentrating on ribosomal RNA structural motifs. After coming back to Strasbourg, he was appointed as a CNRS Research Scientist. He was promoted to Research Director in 2016, acknowledging his important contributions in the RNA structural biology field. Wade Winkler is an Associate Professor of Cell Biology and Molecular Genetics at the University of Maryland (USA). He acquired a graduate degree from The Ohio State University before spending three years as a postdoctoral researcher at Yale University. In 2004, he began his independent scientific career at The University of Texas Southwestern Medical Center in the Department of Biochemistry, and relocated his laboratory to the University of Maryland in 2011. Through the years, Professor Winkler has authored multiple influential publications on the different types of regulatory RNAs in bacteria.

Produkt-Details

• Erscheint lt. Verlag: 1.9.2021
• Verlagsort: Weinheim
• Sprache: englisch
• Maße: 150 x 250 mm
• Gewicht: 666 g
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• ISBN-10: 3-527-81452-3 / 3527814523
• ISBN-13: 978-3-527-81452-7 / 9783527814527
• Zustand: Neuware