Mitochondrial Dysfunction in Aging and Diseases of Aging

Buch | Softcover

270 Seiten

2019
MDPI (Verlag)
9783039213276 (ISBN)

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This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.

Erscheinungsdatum	14.10.2019
Verlagsort	Basel
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Naturwissenschaften ► Biologie ► Allgemeines / Lexika
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	1,25(OH)2D • 25(OH)D • adaptive immunity • Aerobic • Ageing • Age-Related Diseases • Age-related macular degeneration • aging • ALS • Alzheimer’s disease • autophagy • axonal transport • Cancer • cardiomyopathy • Cardiovascular Disease • cell danger response • Coenzyme Q10 • crabtree effect • cytokines • de-emergence • Diabetic retinopathy • DNA Damage • drug-induced mitochondrial toxicity • eIF2α • exercise • exosomes • Genetic Mutations • glaucoma • healing cycle • Heart Failure • Immunosenescence • inflammation • Innate Immunity • insulin resistance • integrated cell stress response • Lysosome • metabokines • Metabolism • Miro1 • mitochondria • mitochondrial • mitochondrial dysfunction • mitochondrial transfer • mitophagy • morbidity and mortality • Multiple Sclerosis • N/A • NAD+ • Neurodegeneration • Neurodegenerative Disease • Neuroinflammation • nucleotide metabolism • Optic nerve • Parkin • Parkinson’s disease • pasteur effect • photoageing • PINK1 • Polypharmacy • prevention • proteostasis • Purinergic signaling • Reactive oxygen species • retina • ROS • senescence • Skin • SOD1 • Sphingolipids • Stress response • type 2 diabetes • Ultraviolet
ISBN-13	9783039213276 / 9783039213276
Zustand	Neuware