Nanomaterials for Advanced Biological Applications (eBook)

Moones Rahmandoust, Majid R. Ayatollahi (Herausgeber)

eBook Download: PDF

2019
XII, 224 Seiten
Springer International Publishing (Verlag)
978-3-030-10834-2 (ISBN)

Infos

This book presents an overview of the ways in which the latest experimental and theoretical nanotechnologies are serving the fields of biotechnology, medicine, and biomaterials. They not only enhance the efficiency of common therapeutics and lower their risks, but thanks to their specific properties, they also provide new capabilities. Nano-scale measurement techniques, such as nano-indentation and nano-scratch methods, could potentially be used to characterize the physical and mechanical properties of both natural tissues and synthetic biomaterials in terms of strength and durability.

Inhalt

Preface 6
Contents 10
Contributors 11
Nanoparticles and Biological Environment Interactions 13
1 Introduction 13
2 Formation and Composition 14
3 Evaluating Protein Corona 17
3.1 Experimental Approach 17
3.2 Computational Approach 18
4 Factors Affecting Protein Corona 19
5 Impacts of Protein Corona on Nanoparticle Behaviour 20
6 Opportunities and Challenges 23
7 Personalized Protein Corona 26
8 Conclusion 26
References 27
Nanotopographical Control of Cell Assembly into Supracellular Structures 30
1 Cell Adhesion Molecules (CAMs) Control the Organization of Cells Within the ECM 30
2 Nanotechnology, Scaffolds and Artificial Analogues of the ECM 31
3 Generation of Nano-patterned Surfaces 32
3.1 Generating Rough Surfaces Using Wet Etching Procedures 32
3.2 Generating Nanoporous Surfaces Using Electrochemical Wet Etching 34
3.3 Silver and Gold Nanoparticle Clusters Obtained by Electroless Deposition 35
3.4 Lithography Techniques for the Definition of Periodic Nanostructures 37
3.5 Reactive Ion Etching Techniques for the Fabrication of Super-Hydrophobic, 2 + 1 Dimensional Surfaces 38
4 Characterization of Nano-Patterned Surfaces 39
4.1 Fractal Dimension of a Surface 39
4.2 Diffusion Limited Aggregation (DLA) of Atoms into Supramolecular Structures 41
4.3 Surface Wettability, Cassie Baxter and Recursive Cassie Baxter 42
5 Characterization of Cell Networks 44
5.1 Network Analysis and Cell Network Topology 44
6 Shannon Information Entropy in Cell Networks 46
7 Cell Adhesion and Proliferation on Nano-patterned Surfaces 48
7.1 Cell Adhesion on Nano-scale Rough Surfaces 48
7.2 Cell Adhesion on Porous Silicon Surfaces 50
7.3 Controlling Cell Adhesion and Proliferation on Fractal Surfaces 50
8 Measuring CAMs on Nano-patterned Surfaces 51
9 Cell Networking on Nano-patterned Surfaces 53
9.1 The Topology of Neuronal Networks on Nano-patterned Surfaces 53
9.2 Nano-scale Cues Influence Information Flow in Planar Neuronal Networks 55
9.3 3D Neuronal Networking 56
10 Possible Physical Reasons for Cell Clustering: Minimization of Energy Density 57
10.1 Free Energy Landscape of Small World Neuronal Networks 57
10.2 Out of Equilibrium Self-assembly 58
11 The Equivalence Principle in the Self-assembly of Cells 60
References 61
Polymeric Nanoparticulates as Efficient Anticancer Drugs Delivery Systems 65
1 Introduction 65
2 Polymeric Nanoparticulate Systems as Platforms for Drug and Gene Delivery 66
2.1 Natural-Based Polymers as Building Blocks of NPs 67
2.2 Synthetic-Based Polymers as Building Blocks of NPs 73
3 Active Targeting Utilizing Ligand Decorated NPs 76
3.1 Monoclonal Antibodies (mAbs) 77
3.2 Folic Acid 79
3.3 Transferrin 80
3.4 Peptide 81
3.5 Saccharides 83
3.6 Aptamers 83
4 Polymeric Nanoparticles Marketed and Under Clinical Trials 84
5 Conclusion 85
References 85
Hydroxyapatite for Biomedicine and Drug Delivery 95
1 Introduction 95
2 Different Synthesis Methods 98
3 Applications 99
4 Tissue Engineering 103
5 Antibacterial Activity 107
6 Ions Substitutions 109
7 Dental Treatment 110
8 Implant 112
9 Drug Delivery 113
10 Conclusion 119
References 120
Nanoparticles for Biosensing 131
1 Introduction 131
2 Biosensor Structure 132
2.1 Biosensors Categorization Based on the Type of Analyte 133
2.2 Biosensors Categorization Based on Transformations 134
3 Biorecognition Elements 134
3.1 Receptors 134
3.2 Enzyme-Based Recognition 134
3.3 Antibody-Based Recognition 135
3.4 Aptamer-Based Recognition 135
3.5 Peptide Nucleic Acid (PNA)-Based Recognition 135
3.6 Molecular Imprint Based Recognition 136
3.7 Lectin-Based Recognition 136
4 Acoustic Based Biosensors 136
4.1 Bulk Acoustic Wave (BAW) Devices 138
4.2 Surface Acoustic Wave Sensors (SAW) 139
4.3 Micro/Nano-electromechanical Systems (MEMs/NEMs) 140
5 Optical Biosensors 140
5.1 Surface Plasmon Resonance (SPR) Biosensors 140
5.2 SPR Imaging 141
5.3 Localized Surface Plasmon Resonance (LSPR) 142
5.4 Evanescent Wave Fluorescence Biosensors 143
5.5 Bioluminescent Optical Fibre Biosensors 144
5.6 Some Other Types of Optical Biosensors 144
6 Electrochemical Biosensors 145
6.1 Amperometric Biosensors 145
6.2 Impedimetric Sensors 146
6.3 Chronocoulometric Sensors 147
6.4 Nanoparticle, Nanowire and Nanotube’s Roles 148
6.5 Nanowires and Nanotubes 148
6.6 Graphene-Based Electrochemical Biosensors 149
7 Thermal Biosensors 149
8 Magnetic Nanoparticle Sensors 149
8.1 Magnetic Relaxation Switch Assay-Sensors 150
8.2 Magnetic Particle Relaxation Sensors 150
8.3 Magnetoresistive Sensors 150
References 150
Carbon Quantum Dots in Nanobiotechnology 154
1 Introduction 154
2 Carbon Quantum Dots Structure 156
3 Carbon Quantum Dots Synthesis 156
3.1 Hydrothermal/Solvothermal Treatment 157
3.2 Microwave Irradiation 157
3.3 Carbonization 159
3.4 Laser Ablation 159
3.5 Chemical Ablation 161
4 Photoluminescence Mechanism in CQDs 161
4.1 Quantum Confinement Derived PL 162
4.2 Surface State Derived PL 163
5 Biocompatibility and Cytotoxicity 164
6 Upconversion PL of CQDs 165
7 Bioimaging 166
7.1 In Vitro Bioimaging 168
7.2 In Vivo Bioimaging 173
8 Biosensing 175
9 Drug Delivery 176
10 Wound-Dressing 179
11 Photocatalysis 179
12 Conclusion 180
References 181
Size-Dependent Nonlinear Mechanics of Biological Nanoporous Microbeams 189
1 Introduction 189
2 Analytical Extracted Properties of Nanoporous Biomaterials 191
3 Nonlocal Strain Gradient Hyperbolic Shear Deformable Beam Model 198
4 Numerical Results and Discussion 204
5 Conclusion 207
Appendix A 209
References 210
Mechanical Behaviour of PMMA Bio-polymer Loaded by Nano-scale Additives 216
1 Introduction 217
2 Acrylic Bone Cement 218
3 Mechanical and Tribological Properties of the PMMA Bone Cement 219
4 PMMA Bone Cement Composites and Nanocomposites 220
5 Hydroxyapatite 223
6 PMMA/HA Bone Cement Nano-Composites 225
7 Constitutive Material Model for the PMMA Bone Cement 226
8 Conclusion 229
References 229

Produkt-Details

• Erscheint lt. Verlag: 29.1.2019
• Reihe/Serie: Advanced Structured Materials
• Reihe/Serie: Advanced Structured Materials
• Zusatzinfo: XII, 224 p. 74 illus., 55 illus. in color.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Naturwissenschaften ► Physik / Astronomie
• Themenwelt: Technik ► Maschinenbau
• Schlagworte: Luminescent quantum dots • Medical nanotechnology • Nanoagents • Nanodevice • Nanotherapeutics • Theranostic methods
• ISBN-10: 3-030-10834-1 / 3030108341
• ISBN-13: 978-3-030-10834-2 / 9783030108342