Leucine-Rich Repeat Kinase 2 (LRRK2)
Springer International Publishing (Verlag)
978-3-319-84287-5 (ISBN)
Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson's Disease.- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson's disease.- Clinical features of LRRK2 carriers with Parkinson's disease.- Part II: Fundamentals of LRRK2 Biology.- LRRK2 phosphorylation.- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity.- LRRK2 and autophagy.- Molecular insights and functional implication of LRRK2 dimerization.- LRRK2 and the immune system.- Regulation of LRRK2 by phosphatases.- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options.- Animal models of LRRK2-associated Parkinson's disease.- LRRK2 and the "LRRKtosome" at the crossroads of programmed cell death: Clues from RIP kinase relatives.- Interaction of LRRK2 and -synuclein in Parkinson's disease.- Mechanisms of mutant LRRK2 neurodegeneration.- Small molecule inhibitors of LRRK2.
Erscheinungsdatum | 03.10.2018 |
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Reihe/Serie | Advances in Neurobiology |
Zusatzinfo | XVII, 271 p. 27 illus., 17 illus. in color. |
Verlagsort | Cham |
Sprache | englisch |
Maße | 155 x 235 mm |
Gewicht | 450 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
Medizin / Pharmazie ► Studium | |
Naturwissenschaften ► Biologie ► Humanbiologie | |
Schlagworte | GTPase • Kinase • Neurodegeneration • Parkinson's Disease • Signaling |
ISBN-10 | 3-319-84287-0 / 3319842870 |
ISBN-13 | 978-3-319-84287-5 / 9783319842875 |
Zustand | Neuware |
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