The Long and Short Non-coding RNAs in Cancer Biology

Buch | Softcover

458 Seiten

2018 | Softcover Reprint of the Original 1st 2016 ed.
Springer Verlag, Singapore
9789811093678 (ISBN)

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The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.

Dr. Erwei Song is a professor at SunYat-Sen Memorial Hospital, Guangzhou, China.

Non-coding RNAs: New Players in Cancers.- The Working Modules of Long Non-coding RNAs in Cancer Cells.- Methods to Study Long Non-coding RNA Biology in Cancer.- Relationship between Non-coding RNA Dysregulation and Epigenetic Mechanisms in Cancer.- Non-coding RNAs in Growth and Death of Cancer Cells.- Non-coding RNAs in Cancer Cell Plasticity.- Non-coding RNAs in Regulation of Cancer Metabolic Reprogramming.- Non-coding RNAs in Tumor Angiogenesis.- Non-coding RNAs in Cancer Immunity.- Non-coding RNAs in Therapeutic Resistance of Cancer.- Non-coding RNAs Regulating Cancer Signaling Network.- Non-coding RNAs Regulating NFkB Signaling.- Non-coding RNAs Regulating p53 and c-Myc Signaling.- Viral Non-coding RNAs in Cancer Biology.- Non-coding RNAs in Cancer Diagnosis.- Therapeutic Potentials of Non-coding RNAs: Targeted Delivery of NcRNAs in Cancer Cells.

Erscheinungsdatum	18.08.2018
Reihe/Serie	Advances in Experimental Medicine and Biology ; 927
Zusatzinfo	21 Illustrations, black and white
Verlagsort	Singapore
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
Schlagworte	Cancer Biology • cancer diagnosis • diagnostic biomarkers • long non-coding RNAs • microRNA • therapeutic targets
ISBN-13	9789811093678 / 9789811093678
Zustand	Neuware