Glucose-sensing Receptor in Pancreatic Beta-cells
Seiten
2019
|
2018 ed.
Springer Verlag, Singapore
978-981-13-0001-1 (ISBN)
Springer Verlag, Singapore
978-981-13-0001-1 (ISBN)
Since the 1970s, there has been much discussion about the “glucoreceptor” and “substrate site” and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the “glucoreceptor theory.”
This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells.
The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: “glucoreceptor theory”.
Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes.
This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells.
The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: “glucoreceptor theory”.
Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes.
Itaru Kojima, M.D. Professor Emeritus Institute for Molecular & Cellular Regulation, Gunma University
1 HISTORY OF THE RESEARCH ON THE GLUCOSE RECEPTOR .- 2 Cell-surface Glucoreceptor Recognizing Anomers of Glucose in Pancreatic b-cells .- 3 KATP CHANNEL-INDEPENDENT PATHWAY and THE GLUCORECEPTOR .- 4 Signaling System Activated by the Glucose-sensing Receptor.- 5 The Role of the Glucose-sensing Receptor in Glucose-induced Insulin Secretion in Pancreatic b-cells.
| Erscheinungsdatum | 09.09.2018 |
|---|---|
| Zusatzinfo | 7 Illustrations, color; 8 Illustrations, black and white; V, 71 p. 15 illus., 7 illus. in color. |
| Verlagsort | Singapore |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
| Naturwissenschaften ► Biologie | |
| ISBN-10 | 981-13-0001-1 / 9811300011 |
| ISBN-13 | 978-981-13-0001-1 / 9789811300011 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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