Pharmacokinetic/pharmacodynamic-guided optimisation of monoclonal antibody therapy in special populations

Helena Edlund (Autor)

Buch | Softcover

210 Seiten

2018
Shaker (Verlag)
978-3-8440-5764-5 (ISBN)

Infos

Monoclonal antibodies constitute a therapeutically and economically important drug class, evident by the growing number on the market and in drug development. Still, sub-optimal use of monoclonal antibodies can result in loss of response or adverse events. In this thesis, pharmacometric modelling and simulation methodologies were applied to contribute to the pharmacokinetic/pharmacodynamic understanding of monoclonal antibodies in two populations, namely children and patients with Crohn's disease.

Produkt-Details

• Erscheinungsdatum: 20.02.2018
• Reihe/Serie: Berichte aus der Pharmazie
• Verlagsort: Aachen
• Sprache: englisch
• Maße: 148 x 210 mm
• Gewicht: 278 g
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Medizin / Pharmazie ► Pharmazie ► PTA / PKA
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Schlagworte: anti-drug antibodies • clinical pharmacy • Crohn's disease • Infliximab • MABS • monoclonal antibodies • PK/PD processes of mAbs
• ISBN-10: 3-8440-5764-1 / 3844057641
• ISBN-13: 978-3-8440-5764-5 / 9783844057645
• Zustand: Neuware