Big Data in Omics and Imaging
Integrated Analysis and Causal Inference
Seiten
2018
Crc Press Inc (Verlag)
978-0-8153-8710-7 (ISBN)
Crc Press Inc (Verlag)
978-0-8153-8710-7 (ISBN)
Emerging genomic, epigenomic, sensing and image technologies will produce massive, dimensional genomic, epigenomic, physiological, image and clinical data. The book is designed to introduce the currently developed statistical methods and software for big genomic and epigenomic data analysis.
Big Data in Omics and Imaging: Integrated Analysis and Causal Inference addresses the recent development of integrated genomic, epigenomic and imaging data analysis and causal inference in big data era. Despite significant progress in dissecting the genetic architecture of complex diseases by genome-wide association studies (GWAS), genome-wide expression studies (GWES), and epigenome-wide association studies (EWAS), the overall contribution of the new identified genetic variants is small and a large fraction of genetic variants is still hidden. Understanding the etiology and causal chain of mechanism underlying complex diseases remains elusive. It is time to bring big data, machine learning and causal revolution to developing a new generation of genetic analysis for shifting the current paradigm of genetic analysis from shallow association analysis to deep causal inference and from genetic analysis alone to integrated omics and imaging data analysis for unraveling the mechanism of complex diseases.
FEATURES
Provides a natural extension and companion volume to Big Data in Omic and Imaging: Association Analysis, but can be read independently.
Introduce causal inference theory to genomic, epigenomic and imaging data analysis
Develop novel statistics for genome-wide causation studies and epigenome-wide causation studies.
Bridge the gap between the traditional association analysis and modern causation analysis
Use combinatorial optimization methods and various causal models as a general framework for inferring multilevel omic and image causal networks
Present statistical methods and computational algorithms for searching causal paths from genetic variant to disease
Develop causal machine learning methods integrating causal inference and machine learning
Develop statistics for testing significant difference in directed edge, path, and graphs, and for assessing causal relationships between two networks
The book is designed for graduate students and researchers in genomics, epigenomics, medical image, bioinformatics, and data science. Topics covered are: mathematical formulation of causal inference, information geometry for causal inference, topology group and Haar measure, additive noise models, distance correlation, multivariate causal inference and causal networks, dynamic causal networks, multivariate and functional structural equation models, mixed structural equation models, causal inference with confounders, integer programming, deep learning and differential equations for wearable computing, genetic analysis of function-valued traits, RNA-seq data analysis, causal networks for genetic methylation analysis, gene expression and methylation deconvolution, cell –specific causal networks, deep learning for image segmentation and image analysis, imaging and genomic data analysis, integrated multilevel causal genomic, epigenomic and imaging data analysis.
Big Data in Omics and Imaging: Integrated Analysis and Causal Inference addresses the recent development of integrated genomic, epigenomic and imaging data analysis and causal inference in big data era. Despite significant progress in dissecting the genetic architecture of complex diseases by genome-wide association studies (GWAS), genome-wide expression studies (GWES), and epigenome-wide association studies (EWAS), the overall contribution of the new identified genetic variants is small and a large fraction of genetic variants is still hidden. Understanding the etiology and causal chain of mechanism underlying complex diseases remains elusive. It is time to bring big data, machine learning and causal revolution to developing a new generation of genetic analysis for shifting the current paradigm of genetic analysis from shallow association analysis to deep causal inference and from genetic analysis alone to integrated omics and imaging data analysis for unraveling the mechanism of complex diseases.
FEATURES
Provides a natural extension and companion volume to Big Data in Omic and Imaging: Association Analysis, but can be read independently.
Introduce causal inference theory to genomic, epigenomic and imaging data analysis
Develop novel statistics for genome-wide causation studies and epigenome-wide causation studies.
Bridge the gap between the traditional association analysis and modern causation analysis
Use combinatorial optimization methods and various causal models as a general framework for inferring multilevel omic and image causal networks
Present statistical methods and computational algorithms for searching causal paths from genetic variant to disease
Develop causal machine learning methods integrating causal inference and machine learning
Develop statistics for testing significant difference in directed edge, path, and graphs, and for assessing causal relationships between two networks
The book is designed for graduate students and researchers in genomics, epigenomics, medical image, bioinformatics, and data science. Topics covered are: mathematical formulation of causal inference, information geometry for causal inference, topology group and Haar measure, additive noise models, distance correlation, multivariate causal inference and causal networks, dynamic causal networks, multivariate and functional structural equation models, mixed structural equation models, causal inference with confounders, integer programming, deep learning and differential equations for wearable computing, genetic analysis of function-valued traits, RNA-seq data analysis, causal networks for genetic methylation analysis, gene expression and methylation deconvolution, cell –specific causal networks, deep learning for image segmentation and image analysis, imaging and genomic data analysis, integrated multilevel causal genomic, epigenomic and imaging data analysis.
Momiao Xiong is a professor of Biostatistics at the University of Texas Health Science Center in Houston where he has worked since 1997. He received his PhD in 1993 from the University of Georgia.
Preface
Author
1. Genotype–Phenotype Network Analysis
2. Causal Analysis and Network Biology
3. Wearable Computing and Genetic Analysis of Function-Valued Traits
4. RNA-Seq Data Analysis
5. Methylation Data Analysis
6. Imaging and Genomics
7. From Association Analysis to Integrated Causal Inference
References
Index
| Erscheinungsdatum | 10.07.2018 |
|---|---|
| Reihe/Serie | Chapman & Hall/CRC Computational Biology Series |
| Zusatzinfo | 30 Tables, black and white; 40 Illustrations, black and white |
| Verlagsort | Bosa Roca |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Gewicht | 616 g |
| Themenwelt | Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie |
| ISBN-10 | 0-8153-8710-5 / 0815387105 |
| ISBN-13 | 978-0-8153-8710-7 / 9780815387107 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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CHF 34,90
