Developmental Origins of Health and Disease (DOHaD)

From Biological Basis to Clinical Significance

Takeo Kubota, Hideoki Fukuoka (Herausgeber)

Buch | Hardcover

95 Seiten

2018 | 1st ed. 2017
Springer Verlag, Singapore
978-981-10-5525-6 (ISBN)

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This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period. It discusses our current understanding of the molecular mechanisms of DOHaD, including gene body epigenetics and non-coding RNA, and comprehensively examines diseases such type 2 diabetes, a well known as standard DOHaD-associated disease, as well as non-alcoholic fatty liver disease, hypertension and neurodevelopmental disorders. It argues that most adult diseases start at a very early stage, such as in the fetal and neonatal periods, and that earlier prevention and intervention would result in better outcomes for adult diseases such as type 2 diabetes and cardiac disorders, which are increasing in both developed and developing countries. The book appeals to obstetricians and pediatricians, as well as physicians who treat adult patients, wanting to understand the origins of diseases.

Takeo Kubota Faculty of Child Studies, Seitoku University, Chiba, Japan Hideoki Fukuoka Research Institute for Science and Engineering, Waseda University, Tokyo, Japan

Part 1 Biological Basis.- One carbon metabolism and lipid metabolism in DOHaD.- Novel models of epigenetic gene regulation in the nutritional environment.- Epigenetic switching and neonatal nutritional environment.- Part 2 Disease and environment.- Developmental Origins of Non-Alcoholic Fatty Liver Disease (NAFLD).- Fetal origins of hypertension.- Involvement of noncoding RNAs in stress-related neuropsychiatric diseases caused by DOCaD theory.- Part 3 Transgenerational mechanism and its consequences.- Placental development and nutritional environment.- Risk of neurodevelopmental disease by paternal aging: a possible influence of epigenetic alteration in sperm.- Part 4 Clinical Significance.- Preemptive epigenetic medicine based on fetal programming.

Erscheinungsdatum	20.07.2018
Reihe/Serie	Advances in Experimental Medicine and Biology ; 1012
Zusatzinfo	16 Illustrations, color; 7 Illustrations, black and white; VII, 95 p. 23 illus., 16 illus. in color.
Verlagsort	Singapore
Sprache	englisch
Maße	178 x 254 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 1. Studienabschnitt (Vorklinik) ► Histologie / Embryologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	epigenome • Maternal under-nutrition • Metabolic disease • Nutritional environment • Pre-emptive medicine
ISBN-10	981-10-5525-4 / 9811055254
ISBN-13	978-981-10-5525-6 / 9789811055256
Zustand	Neuware