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Methods for Reversing Protein Modification

Ubiquitin and SUMO-specific Proteases

Tasneem Bawa-Khalfe, Jinke Cheng (Herausgeber)

Buch | Hardcover

300 Seiten

2021
Routledge (Verlag)
9781138196544 (ISBN)

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Protein posttranslational modification with peptide tags ubiquitin or small ubiquitin-like modifier (SUMO) orchestrate multiple cellular events to ensure normal physiology. These simple enzymatic activities maintain homeostasis of protein modification and normal cell function. This book addresses major proteases - ubiquitin and/or SUMO proteases - involved in posttranslational modification of proteins. Themes reviewed include the difficulty of assigning substrate specificity to the individual de-ubiquitylases (DUBs), selectivity for processing ubiquitin poly-chains, and defining substrate profiles for the different SUMO proteases.

Key selling features:

Assigns substrate specificity to enzymes that constitute the de-ubiquitylase (DUB) family

Describes DUBs selectivity for processing select ubiquitin poly-chains

Defines substrate profiles for the different small ubiquitin-like modifier (SUMO) proteases

Explores enzymatic activity of individual Ubiquitin/SUMO proteases

Tasneem Bawa-Khalfe is Assistant Professor in the Center for Nuclear Receptors and Cell Signaling in the Department of Biology and Biochemistry of the University of Houston. The research focus of the Bawa-Khalfe laboratory is on how cancer cells exploit select post-translational modification (PTM) systems to drive cancer progression. Jinke Cheng is Professor and Chairman of the Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Methods for Ubiquitin Proteases. Evaluating the Substrate Specificity of DUBs. Processing of Poly-Ubiquitin Chains and Impact on Cell Signaling. Studies on Posttranslational Modification of DUBs and Enzymatic activity. Allosteric Regulation of DUB Activity. Orchestrated Recruitment of Multiple DUBs for S-phase Progression. Natural Compounds for Inhibition of DUB Activity in Cancer Cells. Methods for SUMO Proteases. Strategies for Evaluating the Substrate Specificity of SENPs. A Study on Enzyme Kinetics of SENP. Defining the Function of DeSI Family Members. Evaluating SUMO Protease Activity at Adheren Junctions in C. elegans. SENP1-regulated NF kappa B Signal in Type-1 Diabetes Progression. Identifying Small Molecule Inhibitors for SENPs.

Erscheinungsdatum	08.04.2018
Reihe/Serie	Methods in Signal Transduction Series
Zusatzinfo	8 Illustrations, color; 67 Illustrations, black and white
Verlagsort	London
Sprache	englisch
Maße	156 x 235 mm
Themenwelt	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
ISBN-13	9781138196544 / 9781138196544
Zustand	Neuware