Continuous-Flow Chemistry in the Research Laboratory (eBook)

Modern Organic Chemistry in Dedicated Reactors at the Dawn of the 21st Century

Toma Glasnov (Autor)

eBook Download: PDF

2016 | 1. Auflage
VIII, 119 Seiten
Springer-Verlag
978-3-319-32196-7 (ISBN)

Infos

This book presents a short introduction to the historical background to the field, the state of the art and a brief survey of the available instrumentation and the processing techniques used. The following major areas of interest in synthetic, organic and medicinal chemistry are elaborated on: transition-metal catalyzed reactions, organocatalytic transformations, heterocyclic synthesis, and photochemical reactions. Finally, selected applications in industry are also discussed. With its ample presentation of examples from recent literature, this is an essential and reliable source of information for both experienced researchers and postgraduate newcomers to the field.

Toma Glasnov is currently holding an Assistant Professor position and is the head of the Christian Doppler Laboratory for Flow Chemistry at the Institute of Chemistry (KFU-Graz). His research is devoted on the application of continuous-flow processing in the area of organic synthesis focusing on hazardous reactions, high-temperature/pressure syntheses as well as photochemical reactions, multicomponent synthesis and synthesis of biologically active molecules and molecular sensors.

Inhalt

Preface 6
Contents 8
Chapter 1: Continuous Flow Synthesis: A Short Perspective 10
References 12
Selected Recent Books on Organic Synthesis Under Continuous Flow Conditions 12
Selected Recent Reviews on Organic Synthesis Under Continuous Flow Conditions (2010-2015) 12
Chapter 2: Equipment Overview 15
2.1 The ``Build-It-Yourself (BIY)´´ Approach 15
2.2 Dedicated Continuous Flow Systems for Organic Synthesis 15
2.2.1 ThalesNano Nantechnology Inc. [3, 4] 16
2.2.1.1 H-CubeTM 16
2.2.1.2 H-Cube ProTM 16
2.2.1.3 H-Cube MidiTM 17
2.2.1.4 H-Cube MiniTM 17
2.2.1.5 Phoenix Flow ReactorTM 17
2.2.1.6 IceCubeTM Flow Reactor 18
2.2.2 Syrris [8] 19
2.2.2.1 ASIA Modular SystemTM 19
2.2.2.2 AFRICA Modular SystemTM 19
2.2.3 Vapourtec Ltd [10] 20
2.2.3.1 R-Series Modular System 20
2.2.3.2 E-Series Modular System 20
2.2.4 Uniqsis Ltd [11] 21
2.2.4.1 FlowSynTM 21
2.2.4.2 FlowStartTM 21
2.2.5 Future Chemistry Holding BV [12] 22
2.2.5.1 Flow Start Evo 22
2.2.5.2 Flow Start Expert 23
2.2.6 Chemtrix BV [13] 23
2.2.6.1 Labtrix Start 23
2.2.6.2 Labtrix S1 24
2.2.6.3 Kiloflow and Plantrix 24
2.2.7 Advion Inc. [14] 25
2.2.7.1 NanoTek 25
2.2.8 YMC Co. Ltd [15] 25
2.2.8.1 The KeyChem Reactors 25
2.2.8.2 CYTOS-200 and CYTOS-2000 25
2.2.9 AM Technology [16] 26
2.2.9.1 Coflore ACR and ATR 26
2.2.10 Ehrfeld [18] 27
2.2.10.1 MMRS 27
2.2.10.2 FlowPlate, ART, and Miprowa 27
2.2.11 Corning [20] 27
2.2.12 Accendo Corporation [21] 27
2.2.12.1 ConjureTM Flow Chemistry 27
2.2.12.2 PropelTM Flow Chemistry 28
References 28
Chapter 3: Organic Synthesis in Dedicated Continuous Flow Systems 29
3.1 Suzuki Reaction 29
3.2 Heck Reaction 32
3.3 Sonogashira Reaction 33
3.4 Negishi Reaction 34
3.5 Carbonylations 35
3.6 Carbon-Heteroatom Coupling Reactions 36
3.7 Miscellaneous 39
References 40
Chapter 4: Organic Synthesis in Dedicated Continuous Flow Systems 41
4.1 Curtius Rearrangement 41
4.2 Rearrangement of Cyclobutanones 42
4.3 Miscellaneous 43
References 44
Chapter 5: Organic Synthesis in Dedicated Continuous Flow Systems 46
5.1 Diels-Alder Cycloadditions 46
5.2 [3+2] Cycloadditions 47
5.3 Miscellaneous Cycloadditions 52
References 53
Chapter 6: Organic Synthesis in Dedicated Continuous Flow Systems 55
6.1 Reductions 55
6.1.1 Hydrogenation 55
6.2 Hydrogenolysis 62
6.3 Reductive Amination 64
6.4 Oxidations 67
References 70
Chapter 7: Organic Synthesis in Dedicated Continuous Flow Systems 74
7.1 Heterocyclic Syntheses 74
7.2 Multistep Syntheses 83
References 85
Chapter 8: Organic Synthesis in Dedicated Continuous Flow Systems 88
8.1 [18F]-Labeled PET Radiotracers 88
8.2 Miscellaneous 91
References 92
Chapter 9: Organic Synthesis in Dedicated Continuous Flow Systems 94
9.1 Enzymatic Esterification and Acetylation 94
9.2 Miscellaneous 96
References 97
Chapter 10: Organic Synthesis in Dedicated Continuous Flow Systems 98
10.1 Photo- and Electrochemistry 98
10.2 Polymerization 99
10.3 Reactions Involving Organometallic Species 100
10.4 Reactions Involving Diazo-Species 103
10.5 Miscellaneous 105
References 114
Chapter 11: Outlook 118
References 119

Produkt-Details

• Erscheint lt. Verlag: 1.6.2016
• Zusatzinfo: VIII, 114 p. 105 illus.
• Verlagsort: Cham
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik
• Schlagworte: Catalytic Reactions • Continuous-flow Processing • Heterocyclic Synthesis • Organocatalytic Transformations • Transition-metal Catalyzed Reactions
• ISBN-10: 3-319-32196-X / 331932196X
• ISBN-13: 978-3-319-32196-7 / 9783319321967