Click Functionalized Nanoprobes for Target Specific Biomedical Applications

Shaista Ilyas (Autor)

Buch | Softcover

195 Seiten

2016
Dr. Hut (Verlag)
9783843926706 (ISBN)

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Engineered superparamagnetic iron oxide nanoparticles (SPIONs) are smart materials for advanced biomedical applications because of their appealing physicochemical properties. These properties entail uniform size, shape, good biocompatibility, chemical inertness, physiological stability, phase purity, high values of saturation magnetization and facile surface functionalization. In this thesis α-Fe2O3- (hematite) and Fe3O4- (magnetite) nanoparticles (NPs) were synthesized using microwave and solvothermal methods. Additionally various reactive organic molecules such as azides and alkynes were attached to the surfaces of particles via “Click chemistry” methods. The click-functionalized particles were studied for selective conjugation of proteins derived from the leaf proteome and also explored for labeling with 68Ga and 177Lu. Furthermore, the labeling of particles with 68Ga or 177Lu for the diagnosis and radio-therapeutic use against cancer cells could be demonstrated.

Erscheinungsdatum	05.07.2016
Reihe/Serie	Anorganische Chemie
Verlagsort	München
Sprache	englisch
Maße	148 x 210 mm
Gewicht	301 g
Einbandart	Paperback
Themenwelt	Naturwissenschaften ► Chemie ► Anorganische Chemie
Schlagworte	Biomedical Applications • Click Functionalized Nanoprobes • Target Specificity
ISBN-13	9783843926706 / 9783843926706
Zustand	Neuware