Applied Biocatalysis (eBook)

From Fundamental Science to Industrial Applications

Lutz Hilterhaus, Andreas Liese, Ulrich Kettling, Garabed Antranikian (Herausgeber)

eBook Download: EPUB

2016
Wiley-VCH Verlag GmbH & Co. KGaA
978-3-527-67714-6 (ISBN)

Infos

This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of 'extreme' reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.

Andreas Liese is Professor for Technical Biocatalysis at the Hamburg University of Technology. He studied chemistry at the University of Bonn, Germany and carried out his doctoral research at the Research Center Jülich, Germany. From 1998 to 2003 he was assistant professor at the University of Bonn and at the same time head of the Enzyme Group within the Institute of Biotechnology II (Prof. Dr. C. Wandrey), Research Center Jülich. During a sabbatical in 2000 at Pfizer Global Research & Development, San Diego, USA, he there initiated a R&D group on biocatalysis. From 2003 to 2004 he worked as associate professor at the University of Münster, soon receiving a full professorship for Technical Biocatalysis 2004 at the Hamburg University of Technology (TUHH) as the director of the Institute of Technical Biocatalysis. In 2003 Liese received the Award of Up-and-Coming Teacher in Higher Education in the field of biotechnology (DECHEMA, Germany). He is elected member of the steering committee 'Biotechnology' of the DECHEMA e.V. since 2005 and elected member of the steering committee of the German Catalysis Society since 2009

Dr. Lutz Hilterhaus is Junior Group Leader at the Institute of Technical Biocatalysis at the TUHH in Hamburg, Germany. He carried out his studies of chemistry at the University Münster before moving to Hamburg. Having obtained his PhD from TUHH in the working group of Prof. Liese in 2008, he spent one year with Prof. Bornscheuer at the University Greifswald before taking up the possibility to start his habilitation at TUHH. Dr. Hilterhaus has authored over 30 scientific publications and has received the 'Karl-Heinz-Ditze Preis für besondere Leistungen in den Ingenieurwissenschaften' in 2008.

Dr. Ulrich Kettling is Head of R&D at the Clariant Biotech & Renewables Center, München. Before he worked at Süd-Chemie AG until Süd-Chemie was acquired by Clariant in 2011. Before joining Süd-Chemie, he was co-founder and Chief Scientific Officer of Direvo Biotech AG, Köln. Dr. Kettling graduated in Biotechnology at the Technical University Braunschweig and obtained his PhD at the Max Planck Institute for Biophysical Chemistry in Göttingen.

Garabed Antranikian is Professor at the Hamburg University of Technology, where he is head of the Institute of Technical Microbiology. He studied Biology at the American University in Beirut. At the University of Göttingen he completed his PhD in Microbiology in 1980 in the laboratory of Professor Gerhard Gottschalk and qualified as a post-doctoral lecturer (Habilitation) in 1988. In 1989 he was appointed to a professorship in Microbiology at the Hamburg University of Technology. He was president of the International Society for Extremophiles and is chief editor of the scientific journal Extremophiles. In 2004 he was awarded the most prestigious prize for environment protection by the president of the Federal Republic of Germany. Since 2007 he is the coordinator of the 'Biocatalysis2021' Cluster and the 'Biorefinery2021' Cluster of the Ministry of Education and Research and he is chairman of IBN Industrial Biotechnology North. He is member of the Academy of Sciences of Hamburg and member of the Union of the German Academies of Sciences (acatech). He was vice president for academic affairs from 2009 to 2011 before he became president of Hamburg University of Technology in April 2011.

Autor

Dr. Lutz Hilterhaus carried out his studies of chemistry at the University Münster before moving to Hamburg. Having obtained his PhD from the Hamburg University of Technology (TUHH) in the working group of Prof. Liese in 2008, he spent one year with Prof. Bornscheuer at the University Greifswald before taking up the possibility to start as a Junior Group Leader at the Institute of Technical Biocatalysis at the TUHH. Dr. Lutz Hilterhaus finalized his habilitation in 2016 and has authored over 30 scientific publications and has received the "Karl-Heinz-Ditze Preis für besondere Leistungen in den Ingenieurwissenschaften" in 2008. Dr. Andreas Liese is Professor at the Hamburg University of Technology, where he is head of the Institute of Technical Biocatalysis. He studied chemistry at the University of Bonn, Germany, and carried out his doctoral research at the Research Center Jülich, Germany. From 1998 to 2003 he was head of the Enzyme Group within the Institute of Biotechnology II (Prof. Dr. C. Wandrey), Research Center Jülich. During a sabbatical in 2000 at Pfizer Global Research & Development, San Diego, USA, he there initiated a R&D group on biocatalysis. From 2003 to 2004 he worked as associate professor at the University of Münster. In 2003 Liese received the Award of Up-and-Coming Teacher in Higher Education in the field of biotechnology (DECHEMA, Germany). Since 2014 he is elected member of the steering committee of the DECHEMA e.V. Dr. Ulrich Kettling is Global Director and Head of Market Segment Industrial Enzymes at Clariant. Before he was Head of Biotechnology R&D and Global Director Biotechnology and Biorefinery at Clariant and Süd-Chemie. Before joining Süd-Chemie, Dr. Kettling was co-founder and Chief Scientific Officer of Direvo Biotech AG. Dr. Kettling graduated in Biotechnology at the Technical University Braunschweig and obtained his PhD at the Max Planck Institute for Biophysical Chemistry in Göttingen. Dr. Garabed Antranikian is Professor at the Hamburg University of Technology, where he is head of the Institute of Technical Microbiology. He studied Biology at the American University in Beirut. At the University of Göttingen he completed his PhD in Microbiology in 1980 in the laboratory of Professor Gerhard Gottschalk and qualified as a post-doctoral lecturer (Habilitation) in 1988. In 1989 he was appointed to a professorship in Microbiology at the Hamburg University of Technology. He was president of the International Society for Extremophiles and is chief editor of the scientific journal Extremophiles. In 2004 he was awarded the most prestigious prize for environment protection by the president of the Federal Republic of Germany. Since 2007 he is the coordinator of the "Biocatalysis2021" Cluster and the "Biorefinery2021" Cluster of the Ministry of Education and Research and he is chairman of IBN Industrial Biotechnology North. Since 2011 he is the president of Hamburg University of Technology.

Inhalt

FERMENTATION & DOWNSTREAM PROCESSING TECHNOLOGIES
Process development tools for fermentations under extreme conditions (ProTool)
Development of fully automated integrated bioprocesses in an industrial compatible pilot plant for the production of heterologous enzymes in yeast
Application of tailor made porous adsorbents in enzymatic processes
In-situ video microscopy for investigation and optimization of protein crystallization in downstream processing
Innovative plasma technology for enzyme immobilization
New membrane adsorber technology for downstream processing in enzyme production

BIOCATALYSIS & BIOTECHNOLOGICAL PRODUCTION PROZESSES
Biocatalysis in high viscous media
COMPASITES: Computer assisted analysis of active centers in proteins
Kongeneric lipases with improved catalytic activity and substrate accessibility
Biocatalytic exploitation of flavonoids
New Bacillus expression systems
First SeSaM-mutagenesis kit for evolutionary biocatalyst design
Development of a probiotic preserving agent for industrial applications
Development of a biotechnological production process for non-natural cyclopeptides - BioPEP
Biocatalytic exploitation of flavor enhancing aroma compounds

STABLE ENZYMES
Enzymatic oxidation systems food and technical applications
Preparation of new perhydrolases: Simultaneous enhancement of specific activity of perhydrolases and reduction of hydrolysis activity
Nucleases and proteases exhibiting improved properties for molecular preanalytics
Stable enzymes for the conversion of high value and uncommon substrates

Textauszug

List of Contributors

Claudia Aldenhoven

Surflay Nanotec GmbH

Max-Planck-Str. 3

12489 Berlin

Germany

 

Garabed Antranikian

Hamburg University of Technology (TUHH)

Institute of Technical Microbiology

Kasernenstr. 12

D-21073 Hamburg

Germany

 

Anne-Katrin Bauer

Leibniz Institute of Plant Biochemistry

Department of Bioorganic Chemistry

Weinberg 3

06120 Halle

Germany

 

Sören Baum

Hamburg University of Technology (TUHH)

Institute of Technical Biocatalysis

Denickestr. 15

21073 Hamburg

Germany

 

Katrien Bernaerts

Urmonderbaan 22

Geleen 6167-RD

The Netherlands

 

Sascha Beutel

Gottfried Wilhelm Leibniz University of Hannover

Institute of Technical Chemistry

Callinstr. 5

30167 Hannover

Germany

 

Uwe T. Bornscheuer

University of Greifswald

Department of Biotechnology and Enzyme Catalysis

Institute of Biochemistry

Felix-Hausdorff-Str. 4

17487 Greifswald

Germany

 

Henrike Brundiek

Enzymicals AG

Walther-Rathenau-Straße 49a

17489 Greifswald

Germany

 

Paul Bubenheim

Hamburg University of Technology (TUHH)

Institute of Technical Biocatalysis

Denickestr. 15

21073 Hamburg

Germany

 

Nediljko Budisa

TU Berlin, Faculty II

Department of Chemistry

Müller-Breslau-Str. 10

10623 Berlin

Germany

 

Kui Chan

EnzymeWorks, Inc.

Division of Research and Development

Zhangjiagang

#603, Gangcheng Rd.

Jiangsu 215600

China

 

Jennifer Chow

University of Hamburg

Biozentrum Klein Flottbek und Botanischer Garten

FB Biologie

Ohnhorststrasse 18

22609 Hamburg

Germany

 

Lars Dähne

Surflay Nanotec GmbH

Max-Planck-Str. 3

12489 Berlin

Germany

 

Alessandro De Simone

TU Berlin, Faculty II

Department of Chemistry

Müller-Breslau-Str. 10

10623 Berlin

Germany

 

Stefaan De Wildeman

Urmonderbaan 22

6167-RD Geleen

The Netherlands

 

Martin Dippe

Leibniz Institute of Plant Biochemistry

Department of Bioorganic Chemistry

Weinberg 3

06120 Halle

Germany

 

Marrit Eckstein

Evonik Nutrition & Care GmbH

Goldschmidtstr. 100

45127 Essen

Germany

 

Gabriella Egri

Surflay Nanotec GmbH

Max-Planck-Str. 3

12489 Berlin

Germany

 

Skander Elleuche

Hamburg University of Technology (TUHH)

Institute of Technical Microbiology

Kasernenstr. 12

D-21073 Hamburg

Germany

 

Rebecca Faschian

Hamburg University of Technology

Institute of Bioprocess and Biosystems Engineering

Denickestr. 15

D-21073 Hamburg

Germany

 

Annamaria Fiethen

University of Essen

CAM-D Technologies GmbH

Schützenbahn 70

45117 Essen

Germany

 

Mechthild Gall

University of Greifswald

Department of Biotechnology and Enzyme Catalysis

Institute of Biochemistry

Felix-Hausdorff-Str. 4

17487 Greifswald

Germany

 

Dominik Gauss

Sigma-Aldrich Chemie GmbH

Industriestr. 25

9470 Buchs

Switzerland

 

Torsten Geißler

Department of Research & Technology

Symrise AG

Mühlenfeldstr. 1

37603 Holzminden

Germany

 

Detlef Goelling

Organobalance GmbH

Gustav-Meyer-Allee 25

13355 Berlin

Germany

 

Egon Gross

Department of Research & Technology

Symrise AG

Mühlenfeldstr. 1

37603 Holzminden

Germany

 

Hendrik Hellmuth

International Research Laundry and Home Care

Biotechnology, Henkel AG & Co. KGaA

Henkelstraße 67

40191 Düsseldorf

Germany

 

Lutz Hilterhaus

Hamburg University of Technology (TUHH)

Institute of Technical Biocatalysis

Denickestr. 15

21073 Hamburg

Germany

 

Michael Hoesl

TU Berlin, Faculty II

Department of Chemistry

Müller-Breslau-Str. 10

10623 Berlin

Germany

 

Matthias Höhne

University of Greifswald

Felix-Hausdorff-Str. 4

17487 Greifswald

Germany

 

Felix Jakob

DWI - Leibniz-Institut für Interaktive Materialien e.V.

Forckenbeckstrasse 50

D-52074 Aachen

Germany

 

P. Jonczyk

Gottfried Wilhelm Leibniz University of Hannover

Institute of Technical Chemistry

Callinstr. 5

30167 Hanover

Germany

 

Xin Ju

EnzymeWorks, Inc.

Division of Research and Development

Zhangjiagang

#603, Gangcheng Rd.

Jiangsu 215600

China

 

Birhanu M. Kinfu

University of Hamburg

Biozentrum Klein Flottbek und Botanischer Garten

FB Biologie

Ohnhorststrasse 18

22609 Hamburg

Germany

 

Anna Krüger

Hamburg University of Technology (TUHH)

Institute of Technical Microbiology

Kasernenstr. 12

D-21073 Hamburg

Germany

 

Hubert Kuhn

University of Essen

CAM-D Technologies GmbH

Schützenbahn 70

45117 Essen

Germany

 

Jakob Ley

Symrise AG

Mühlenfeldstr. 1

37603 Holzminden

Germany

 

Xiaoliang Liang

EnzymeWorks, Inc.

Division of Research and Development

Zhangjiagang

#603, Gangcheng Rd.

Jiangsu 215600

China

 

Andreas Liese

Hamburg University of Technology (TUHH)

Institute of Technical Biocatalysis

Denickestr. 15

21071 Hamburg

Germany

 

Michael G. Lorenz

Molzym GmbH & Co. KG

Mary-Astell-Strasse 10

D-28359 Bremen

Germany

 

Ronny Martinez

RWTH Aachen University

Lehrstuhl für Biotechnologie

Worringerweg 3

D-52074 Aachen

Germany

 

Luuk Mestrom

Urmonderbaan 22

6167-RD Geleen

The Netherlands

 

Getachew S. Molla

Hamburg University of Technology (TUHH)

Institute of Technical Biocatalysis

Denickestr. 15

21071 Hamburg

Germany

 

Jakob J. Mueller

Evonik Industries

Rellinghauser Street 1–11

45128 Essen

Germany

 

and

 

DWI–Leibniz Institute of Interactive Materials

Forckenbeckstrasse 50

D-52074 Aachen

Germany

 

H. Mühl

Molzym GmbH & Co. KG

Mary-Astell-Strasse 10

D-28359 Bremen

Germany

 

Yan Ni

East China University of Science and Technology

Biocatalysis and Synthetic Biotechnology

130 Meilong Road

Shanghai 200237

P.R. China

 

Bernd Niemeyer

Helmut-Schmidt-University

Process Engineering

Holstenhofweg 85

22043 Hamburg

Germany

 

Eva Nittinger

University of Hamburg

Center for Bioinformatics

Bundesstraße 43

20146 Hamburg

Germany

 

Timothy O'Connell

International Research Laundry and Home Care

Biotechnology, Henkel AG & Co. KGaA

Henkelstraße 67

40191 Düsseldorf

Germany

 

Ramesh N. Patel

SLRP Associates, LLC, Consultation in Biotechnology

572 Cabot Hill Road

Bridgewater

NJ 08807

USA

 

Ioannis V. Pavlidis

University of Greifswald

Department of Biotechnology and Enzyme Catalysis

Institute of Biochemistry

Felix-Hausdorff-Str. 4

17487 Greifswald

Germany

 

and

 

University of Kassel

Department of Biochemistry

Institute of Biology

Heinrich-Plett-Str. 40

34132 Kassel

Germany

 

Ralf Pörtner

Hamburg...

Produkt-Details

• Erscheint lt. Verlag: 27.7.2016
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• Schlagworte: Biocatalysis • Biokatalyse • Biotechnologie • Biotechnologie i. d. Chemie • Biotechnology • Chemie • Chemistry • Industrial Applications • <p>fermentation • Nachhaltige u. Grüne Chemie • Nachhaltige u. Grüne Chemie • process development • stability</p> • Sustainable Chemistry & Green Chemistry
• ISBN-10: 3-527-67714-3 / 3527677143
• ISBN-13: 978-3-527-67714-6 / 9783527677146