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Practical Methods for Biocatalysis and Biotransformations 3 (eBook)

eBook Download: EPUB
2016
John Wiley & Sons (Verlag)
978-1-118-69629-3 (ISBN)

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Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities.

Practical Methods for Biocatalysis and Biotransformations 3 will be a companion book to Practical Methods for Biocatalysis and Biotransformations (2009) and Practical Methods for Biocatalysis and Biotransformations 2 (2012). Following the successful format of the two volumes, it will be a 'how-to' guide focusing on commercially available enzymes and strains of microorganisms that are readily obtained from culture collections. The source of starting materials and reagents, hints, tips and safety advice (where appropriate) will be given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology will be given and relevant references to the primary literature will be cited.

Contents include:

  • Biotransformation Process Technology
  • Industrial Biooxidation
  • Hydrolase catalysed hydrolysis/synthesis
  • Reduction
  • Oxidation
  • Halogenation
  • Transferase catalysed glycosylation, methylation, etc
  • C-C bond formation
  • Tandem Biocatalytic Reactions

Practical Methods for Biocatalysis and Biotransformations, Volume 3 is an essential collection of validated biocatalytic methods which will find a place on the bookshelves of synthetic organic chemists, pharmaceutical chemists, and process R&D chemists in industry and academia.


Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities. Practical Methods for Biocatalysis and Biotransformations 3 will be a companion book to Practical Methods for Biocatalysis and Biotransformations (2009) and Practical Methods for Biocatalysis and Biotransformations 2 (2012). Following the successful format of the two volumes, it will be a how-to guide focusing on commercially available enzymes and strains of microorganisms that are readily obtained from culture collections. The source of starting materials and reagents, hints, tips and safety advice (where appropriate) will be given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology will be given and relevant references to the primary literature will be cited. Contents include: Biotransformation Process Technology Industrial Biooxidation Hydrolase catalysed hydrolysis/synthesis Reduction Oxidation Halogenation Transferase catalysed glycosylation, methylation, etc C-C bond formation Tandem Biocatalytic Reactions Practical Methods for Biocatalysis and Biotransformations, Volume 3 is an essential collection of validated biocatalytic methods which will find a place on the bookshelves of synthetic organic chemists, pharmaceutical chemists, and process R&D chemists in industry and academia.

Dr John Whittall, Centre of Excellence for Biocatalysis, Biotransformations and Biocatalytic Manufacture (CoEBio3), Manchester Interdisciplinary Biocentre, University of Manchester, UK. Dr Peter W Sutton, Senior Scientist, GlaxoSmithKline Research and Development Limited, UK. Dr Wolfgang Kroutil, Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Austria.

List of Contributors


Syed T. Ahmed School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, UK

Ian Archer Ingenza Ltd, Roslin BioCentre, UK

Frances H. Arnold Division of Chemistry and Chemical Engineering, California Institute of Technology, USA

Robert Ashe AM Technology, UK

Lara Babich Van't Hoff Institute for Molecular Sciences, University of Amsterdam, The Netherlands

Jan-E. Bäckvall Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden

Maria Bawn Prozomix Limited, UK

Beatrice Bechi School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, UK

Gary Black Northumbria University, Department of Applied Science, UK

Fabrizio Bonina Institute of Pharmaceutical Sciences, Albert Ludwigs University of Freiburg, Germany

Uwe T. Bornscheuer Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, University of Greifswald, Germany

Elisabetta Brenna Department of Chemistry, Material and Chemical Engineering “G. Natta,” Polytechnic University of Milan, Italy

Aleksandra Bury Van't Hoff Institute for Molecular Sciences, University of Amsterdam, The Netherlands

Andrada But Biobased Commodity Chemistry, Wageningen University, The Netherlands

Simon Charnock Prozomix Limited, UK

Bi-Shuang Chen Department of Biotechnology, Delft University of Technology, The Netherlands

Yong-Jun Chen Department of Chemical and Biological Engineering, Zhejiang University, China

Pere Clapés Biotransformation and Bioactive Molecules Group, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Spain

Thomas Classen Institute of Bioorganic Chemistry, Heinrich Heine University Düsseldorf, Germany

Marine Debacker Clermont University, Blaise Pascal University, ICCF, Clermont-Ferrand, France; CNRS, UMR 6296, France

Tom Desmet Centre for Industrial Biotechnology and Biocatalysis, Faculty of Bioscience Engineering, Ghent University, Belgium

Karel De Winter Centre for Industrial Biotechnology and Biocatalysis, Faculty of Bioscience Engineering, Ghent University, Belgium

Griet Dewitte Centre for Industrial Biotechnology and Biocatalysis, Faculty of Bioscience Engineering, Ghent University, Belgium

Alba Díaz-Rodríguez Department of Organic and Inorganic Chemistry, Asturias Institute of Biotechnology, University of Oviedo, Spain

Carola Dresen Institute of Pharmaceutical Sciences, Albert Ludwigs University of Freiburg, Germany

Richard Duncan Prozomix Limited, UK

Marc Dürrenberger Department of Inorganic Chemistry, University of Basel, Switzerland

Tadashi Ema Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Japan

Ulrike Engel Institute of Process Engineering in Life Sciences, Section II: Technical Biology, Karlsruhe Institute of Technology, Germany

Roman S. Esipov Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Russia

Kurt Faber Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Austria

Christopher C. Farwell Division of Chemistry and Chemical Engineering, California Institute of Technology, USA

James Finnigan Prozomix Limited, UK

Christine Fuchs Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Austria

Michael Fuchs Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Austria

Anna Fryszkowska Merck Research Laboratories, USA

Eduardo García-Junceda Department of Bioorganic Chemistry, Institute of General Organic Chemistry, Spain

Gilda Gasparini AM Technology, UK

Francesco G. Gatti Department of Chemistry, Material and Chemical Engineering “G. Natta,” Polytechnic University of Milan, Italy

Edzard M. Geertsema Department of Pharmaceutical Biology, Groningen Research Institute of Pharmacy, University of Groningen, The Netherlands

Laura Getrey DECHEMA Research Institute, Germany

Diego Ghislieri School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, UK

Silvia M. Glueck Austrian Centre of Industrial Biotechnology, Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Austria

Michael Golden AstraZeneca, Chemical Development, UK

Animesh Goswami Chemical Development, Bristol-Myers Squibb, USA

Vicente Gotor Department of Organic and Inorganic Chemistry, Asturias Institute of Biotechnology, University of Oviedo, Spain

Vicente Gotor-Fernández Department of Organic and Inorganic Chemistry, Asturias Institute of Biotechnology, University of Oviedo, Spain

Johannes Gross Austrian Centre of Industrial Biotechnology, Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Austria

Christine Guérard-Hélaine Clermont University, Blaise Pascal University, ICCF, Clermont-Ferrand, France; CNRS, UMR 6296, France

Zhiwei Guo Chemical Development, Bristol-Myers Squibb, USA

Karl P. J. Gustafson Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden

Helen C. Hailes Department of Chemistry, Christopher Ingold Laboratories, University College London, UK

Ulf Hanefeld Department of Biotechnology, Delft University of Technology, The Netherlands

Steven P. Hanlon F. Hoffmann-La Roche Ltd., Switzerland

Aloysius F. Hartog Van't Hoff Institute for Molecular Sciences, University of Amsterdam, The Netherlands

Bernhard Hauer Institute of Technical Biochemistry, University of Stuttgart, Germany

Rachel S. Heath School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, UK

Virgil Hélaine Clermont University, Blaise Pascal University, ICCF, Clermont-Ferrand, France; CNRS, UMR 6296, France

Susanne Herter Institute of Biochemistry, Department of Biotechnology and Enzyme Catalysis, University of Greifswald, Germany

Matthew R. Hickey Chemical Development, Bristol-Myers Squibb, USA

Michael Hofer Fraunhofer Institute for Interfacial Engineering and Biotechnology, Institute branch Straubing, BioCat – Bio-, Chemo- and Electrocatalysis, Germany

Frank Hollmann Department of Biotechnology, Delft University of Technology, The Netherlands

Dirk Holtmann DECHEMA Research Institute, Germany

Karen Holt-Tiffin Dr Reddy's Laboratories Ltd, Chirotech Technology Centre, UK

Roger M. Howard Pfizer Ltd, Chemical Research & Development, UK

Gjalt Huisman Codexis Inc, USA

Shahed Hussain School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, UK

Syed Masood Husain Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Germany

Todd K. Hyster Department of Inorganic Chemistry, University of Basel, Switzerland; Department of Chemistry, Colorado State University, USA

Ed Jones C-Tech Innovation Ltd, UK

Predrag Jovanovic Department of Organic Chemistry, Faculty of Pharmacy, University of Belgrade, Serbia

Shusuke Kamata Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, Japan

Elena Kasparyan Institute of Pharmaceutical Sciences, Albert Ludwigs University of Freiburg, Germany

Hans Kierkels DSM Innovative Synthesis BV, The Netherlands

Matthias Kittelmann NovartisPharma AG, Switzerland

Livia Knörr Department of Inorganic Chemistry, University of Basel, Switzerland

Valentin Köhler Department of Inorganic Chemistry, University of Basel, Switzerland

Pieter de Koning Dr Reddy's Laboratories Ltd, Chirotech Technology Centre, UK

Robert Kourist Junior Research Group for Microbial Biotechnology, Ruhr-University Bochum, Germany

Thomas Krieg DECHEMA Research Institute, Germany

Wolfgang Kroutil Department of Chemistry, Organic and Bioorganic Chemistry, University of Graz, Austria

Jim Lalonde Codexis Inc, USA

Eleanor D. Lamming Department of Chemistry, Christopher Ingold Laboratories, University College London, UK

Alexander Lang General Biochemistry, Dresden University of Technology, Germany

Iván Lavandera Department of Organic and Inorganic Chemistry, Asturias Institute of Biotechnology, University of Oviedo, Spain

Friedemann Leipold School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, UK

Marielle Lemaire Clermont University, Blaise Pascal University, ICCF, Clermont-Ferrand, France; CNRS, UMR 6296, France

Jerôme Le Nôtre Biobased Commodity Chemistry, Wageningen University, The Netherlands

Shu-Ming Li Institute of Pharmaceutical Biology and Biotechnology, Philipp University of Marburg, Germany

Zhi Li Department of...

Erscheint lt. Verlag 16.2.2016
Sprache englisch
Themenwelt Naturwissenschaften Biologie Biochemie
Naturwissenschaften Chemie
Technik Maschinenbau
Technik Umwelttechnik / Biotechnologie
Schlagworte Biocatalysis • Biocatalysts • Biochemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biokatalyse • Biotransformation Process Technology • C-C Bond Formation • Chemical Synthesis • Chemie • Chemistry • Chemists • halogenation • high-tech enzymes • Hydrolase catalysed hydrolysis • hydrolase catalysed synthesis • Industrial Biooxidation • Methods - Synthesis & Techniques • methylation • microorganisms • Organische Chemie • Organische Chemie / Methoden, Synthesen, Verfahren • Oxidation • pharmaceutical chemists • Pharmaceutical science • reduction • Synthetic Organic Chemistry • Tandem Biocatalytic Reactions • Transferase catalysed glycosylation • Whole cell biocatalysts
ISBN-10 1-118-69629-8 / 1118696298
ISBN-13 978-1-118-69629-3 / 9781118696293
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