Medical Epigenetics

Buch | Hardcover

924 Seiten

2016
Academic Press Inc (Verlag)
978-0-12-803239-8 (ISBN)

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Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume.

Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.

Section I: Overview

1. An Overview of Medical Epigenetics
Trygve O. Tollefsbol

Section II: Basic Principles of Epigenetics

2. DNA Methylation: Basic Principles
Cynthia A. Moylan and Susan K. Murphy

3. Histone-deacetylases as a therapeutic target in neurodegenerative diseases
Farahnaz Sananbenesi and Andre Fischer

4. Basic principles of noncoding RNAs in epigenetics
Ilaria Panzeri, Grazisa Rossetti and Massimiliano Pagani

Section III: General Medical Aspects of Epigenetics

5. Epidemiological Epigenetics in Medicine
Alexander Vaiserman

6. Lifestyle and Preventive Medical Epigenetics
Marcus V. Gomes

7. Environmental Medical Epigenetics: A Review of Epigenetically-induced Medical Risks Generated from Exposures in Our Air, Food, and Personal Products
Rachel L. Miller

8. Behavioral Medical Epigenetics
Olivia H. Cox and Richard S. Lee

9. Medical Epigenetics in Twins
Joel C. Eissenberg

10. Epigenetic Biomarkers of Disease
Philip D. Voyias, Abhilasha Patel and Ramesh P. Arasaradnam

11. Prognostic Epigenetics
Anup Sharma, Eihab Abdelfatah, Maryam Al Eissa and Nita Ahuja

Section IV: Epigenetics of System Disorders

12. Immune System Disorders and Epigenetics
Stuti Mehta and Kate L. Jeffrey

13. Pulmonary Diseases and Epigenetics
Hong Peng, Dandan Zong, Zijing Zhou and Ping Chen

14. Cardiovascular Disorders and Epigenetics
Charbel Abi Khalil

15. Epigenomics of Intestinal Disease
Daniel Rory Kelly and Theresa Alenghat

16. Epigenetics of Skin Disorders
Shuaihantian Luo and Qianjin Lu

17. Epigenetics in Bone and Joint Disorders
N. Altorok, S. Nada, V. Nagaraja and Bashar Kahaleh

18. Epigenetics of Muscle Disorders
Viviana Moresi, Nicoletta Marroncelli, Eva Pigna and Sergio Adamo

19. Epigenetics of Psychiatric Disorders
Marija Kundakovic

20. Epigenetic Alterations in Endocrine-dependent Cancers: Implications of Endocrine Dysfunctions
Genevieve Deblois and Mathieu Lupien

21. Reproductive Disease Epigenetics
Rafael Oliva*

22. Epigenetics in Ocular Medicine
Verity F. Oliver, Katherine A. van Bysterveldt and Shannath L. Merbs*

Section V: Multi-system Medical Epigenetics

23. Pediatric Diseases and Epigenetics
Judith G. Hall*

24. Epigenetics of Infectious Diseases
Kate L. Seib and Michael P. Jennings

25. Clinical Utility of Solid Tumor Epigenetics
Søren Kristiansen and György Sölétormos

26. Epigenetic Control in Human Normal Follicular Thyroid Cells and in Thyroid Carcinoma
Zeus Andrea Antonello and Carmelo Nucera

27. Epigenetics in Acute Myeloid Leukemia
Cristina Giorgio, Carmela Dell’Aversana and Lucia Altucci

28. Epigenetic Regulation in Cancer Metastasis
Huan Wang, Yukun Zhang, Adam Kriska and Hong Chen

29. Epigenetics in Exercise Science and Sports Medicine
Philipp Zimmer, Alexander Schenk and Wilhelm Bloch

30. Epigenetic Mechanisms and Inheritance of Acquired Susceptibility to Disease
Rajesh C. Miranda, Nihal A. Salem, Annette S. Fincher, Amanda H. Mahnke and Sasha G. Burrowes

Section VI. Pharmacology of Epigenetics

31. Toxicology and Epigenetics
Jian Tajbakhsh and Jatinder Singh

32. Pharmacoepigenomics
Ramón Cacabelos and Clara Torrellas

Section VII: Therapeutic Epigenetics

33. Therapeutics and DNA Methylation Inhibitors
Sheena Bhalla and Shyamala C. Navada

34. Histone Deacetylase Inhibitors in Medical Therapeutics
Pusoon Chun

35. NAD+-dependent Deacetylases and Medical Therapy
Ashok Kumar, Louisa Ben-Aderet, Jinan Elayan and Mona Dvir-Ginzberg*

36. Experimental Approaches Towards Histone Acetyltransferase Inhibitors as Therapeutics
H. Wapenaar and Frank J. Dekker

37. Histone Methylation Modifiers in Medical Therapeutics
Patrick Trojer

38. Therapeutics of Epigenetic-based RNA molecules
Costas Koufaris* and Vicky Nicolaidou

39. Natural Epigenetic-modifying Molecules in Medical Therapy
Avinash Kumar, Nasir A. Butt and Anait S. Levenson

40. Outcome of Combining Epigenetic Drugs with Other Treatments in the Clinic
Paromita Raha

41. Epigenetics of Pain Management
Beverley Greenwood-Van Meerveld, Dawn Prusator, Casey Ligon, Anthony C. Johnson and Rachel D. Moloney

42. Personalized Epigenetics
Michael Bitzer and Nisar P. Malek

43. Epigenetics and Regenerative Medicine: Neural and Skeletal Muscle Perspectives
Constantin Heil and Daniela Palacios

44. Stem Cell Epigenetics in Medical Therapy
Baoli Cheng, Liqi Shu and Peng Jin

Section VIII: Medical Epigenetics: Future Prospects

45. Prospective Advances in Medical Epigenetics
Junjie Xiao and Guoping Li

Erscheinungsdatum	16.07.2016
Verlagsort	San Diego
Sprache	englisch
Maße	216 x 276 mm
Gewicht	2720 g
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	0-12-803239-1 / 0128032391
ISBN-13	978-0-12-803239-8 / 9780128032398
Zustand	Neuware