Introduction to Proteomics

Tools for the New Biology

Daniel C. Liebler (Autor)

Buch | Hardcover

198 Seiten

2001 | 2002 ed.
Humana Press Inc. (Verlag)
978-0-89603-991-9 (ISBN)

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Daniel C. Liebler masterfully introduces the science of proteomics by spelling out the basics of how one analyzes proteins and proteomes, and just how these approaches are then employed to investigate their roles in living systems. He explains the key concepts of proteomics, how the analytical instrumentation works, what data mining and other software tools do, and how these tools can be integrated to study proteomes. Also discussed are how protein and peptide separation techniques are applied in proteomics, how mass spectrometry is used to identify proteins, and how data analysis software enables protein identification and the mapping of modifications. In addition, there are proteomic approaches for analyzing differential protein expression, characterizing proteomic diversity, and dissecting protein-protein interactions and networks.

I. Proteomics and the Proteome.- 1. Proteomics and the New Biology.- 2. The Proteome.- II. Tools of Proteomics.- 3. Overview of Analytical Proteomics.- 4. Analytical Protein and Peptide Separations.- 5. Protein Digestion Techniques.- 6. Mass Spectrometers for Protein and Peptide Analysis.- 7. Protein Identification by Peptide Mass Fingerprinting.- 8. Peptide Sequence Analysis by Tandem Mass Spectrometry.- 9. Protein Identification with Tandem Mass Spectrometry Data.- 10. SALSA: An Algorithm for Mining Specific Features of Tandem MS Data.- III. Applications of Proteomics.- 11. Mining Proteomes.- 12. Protein Expression Profiling.- 13. Identifying Protein-Protein Interactions and Protein Complexes.- 14. Mapping Protein Modifications.- 15. New Directions in Proteomics.

Erscheint lt. Verlag	4.12.2001
Zusatzinfo	2 Illustrations, color; 29 Illustrations, black and white; IX, 198 p. 31 illus., 2 illus. in color.
Verlagsort	Totowa, NJ
Sprache	englisch
Maße	127 x 203 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Pharmazie
	Naturwissenschaften ► Biologie ► Biochemie
ISBN-10	0-89603-991-9 / 0896039919
ISBN-13	978-0-89603-991-9 / 9780896039919
Zustand	Neuware