Alkaloids: Chemical and Biological Perspectives (eBook)

S.W. Pelletier (Herausgeber)

eBook Download: PDF

2017 | 1. Auflage
303 Seiten
Elsevier Science (Verlag)
978-1-4832-8784-3 (ISBN)

Infos

This monograph series provides unprecedented interdisciplinary coverage of research relating to the chemistry and biological properties of alkaloids - a class of biologically active compounds of more than 10,000 members. Timely, comprehensive and authoritative, the series features chapters on chemical properties and structure elucidation, synthesis, biosynthesis, taxonomy, spectroscopy, pharmacology, toxicology, and X-ray crystallography of alkaloids. The chapters are written and reviewed by eminent researchers, all of them acknowledged experts in the field. Subject and organism indexes are included for each volume.

Inhalt

Front Cover 1
Alkaloids: Chemical and Biological Perspectives 4
Copyright Page 5
Table of Contents 16
Dedication 6
Contributors 8
Preface 10
Contents of Previous Volumes 12
Chapter One. Taxol 18
1. INTRODUCTION 19
2. DISCOVERY OF TAXOL 20
3. STRUCTURE DETERMINATION OF TAXOL 21
4. APPROACHES TO THE SUPPLY OF TAXOL 25
5. MECHANISM OF ACTION OF TAXOL 31
6. STRUCTURE ACTIVITY RELATIONSHIPS (SAR) OF TAXOLAND ANALOGS 32
7. CLINICAL RESULTS 34
REFERENCES 36
Chapter Two. The Synthesis of Macroline Related Sarpagine Alkaloids 40
1. INTRODUCTION 41
2. SYNTHESIS 47
3. BIOLOGICAL ASPECTS OF ALKALOIDS 90
4. SUMMARY 94
REFERENCES 96
Chapter Tree. Erythrina Alkaloids 102
1. INTRODUCTION 103
2. OCCURRENCE AND ISOLATION 104
3. STRUCTURE DETERMINATION 113
4. ABNORMAL ERYTHRINA ALKALOIDS 125
5. BIOSYNTHESIS 129
6. SYNTHESIS 133
7. PHARMACOLOGY 163
8. REFERENCES 164
Chapter Four. Chemistry, Biology and Chemoecology of the Pyrrolizidine Alkaloids 172
1. INTRODUCTION 173
2. SURVEY AND CLASSIFICATION OF PLANT PAs 173
3. BIOSYNTHESIS OF THE NECINE BASES 179
4. BIOSYNTHESIS OF THE NECIC ACIDS 185
5. TRANSPORT, STORAGE AND METABOUSM OF PAs IN PLANTS 187
6. ROLE OF THE PA W-OXIDES IN PLANTS 189
7. ACTIVITIES OF PLANT PAs 191
8. ROLE OF PAs IN PLANT - INSECT - RELATIONSHIPS 192
9. THELOUNES 202
10. CONCLUSIONS 203
REFERENCES 205
APPENDIX I 214
APPENDIXE II 227
Chapter Five. Alkaloids from Cell Cultures of Aspidosperma Quebracho-Bianc 252
1. INTRODUCTION 253
2. SIGNIFICANCE OF ASPIDOSPERMA QUEBRACHO-BIANCO PLANTS 253
3. ESTABLISHMENT OF TISSUE AND CELL CULTURES 255
4. ISOLATION AND STRUCTURE OF ALKALOIDS 256
5. CONCLUSIONS AND FUTURE ASPECTS 261
REFERENCES 262
Chapter Six. Fumonisins 264
1. INTRODUCTION 265
2. FUMONISIN STRUCTURES AND OCCURRENCE 266
3. ANALYSIS, ELUCIDATION OF STRUCTURES AND REACTIONS 269
4. BIOSYNTHESIS OF THE FUMONISINS 283
5. BIOLOGICAL EFFECTS OF FUMONISINS 285
6. RELATED COMPOUNDS 286
SUMMARY 291
REFERENCES 292
Subject Index 296
Organism Index 302

Produkt-Details

• Erscheint lt. Verlag: 3.5.2017
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie ► Organische Chemie
• Themenwelt: Technik
• ISBN-10: 1-4832-8784-X / 148328784X
• ISBN-13: 978-1-4832-8784-3 / 9781483287843