Molecular Genetic Medicine (eBook)

Volume 1

Theodore Friedmann (Herausgeber)

eBook Download: PDF

2013 | 1. Auflage
254 Seiten
Elsevier Science (Verlag)
978-1-4832-6205-5 (ISBN)

Infos

Molecular Genetic Medicine, Volume I, provides an overview of the progress in several of the most important areas of modern molecular genetics and medicine. The aim is to present a technical and historical picture of the concept that it is through a thorough understanding of genetics of all kinds of human diseases, even infectious diseases, that effective treatments will finally come. The book opens with a discussion of the origins and development of the Human Genome Project. This is followed by separate chapters on the development of immune-deficient mice as models for human hematopoietic disease; the application of genetic techniques for testing identity and relatedness of persons; and advances in recombinant DNA technology and their applications in drug discovery. The final chapter discusses the impact of molecular biology and molecular evolution on debates about the origin of humans, and about the origins both of the characteristics that they share with other animals and of those that make humans unique.

Inhalt

Front Cover 1
Molecular Genetic Medicine 4
Copyright Page 5
Table of Contents 6
Contributors 8
Foreword 10
Preface 12
Chapter 1. The Genesis of the Human Genome Project 14
I. INTRODUCTION 14
II. TECHNICAL AND SCIENTIFIC BACKGROUND 15
III. ORIGINS OF GENOME RESEARCH PROGRAMS 24
IV. CONCLUSIONS 80
Acknowledgments 82
References 82
Chapter 2. Immune-Deficient Mice as Models for Human Hematopoietic Disease 90
I. INTRODUCTION 90
II. HEMATOPOIESIS 91
III. GENETIC MANIPULATION OF HEMATOPOIETIC STEM CELLS 98
IV. ENGRAFTMENT OF HUMAN HEMATOPOIETIC CELLS IN IMMUNE-DEFICIENT MICE 103
V. APPLICATIONS 114
VI. SUMMARY 122
Acknowledgments 122
References 123
Chapter 3. An Application of DNA Sequencing to a Human Rights Problem 130
I. INTRODUCTION: THE HISTORICAL CONTEXT 130
II. THE CURRENT STATE OF THE ART OF HUMAN IDENTIFICATION USING GENETIC TECHNIQUES 132
III. SEQUENCING OF MITOCHONDRIAL DNA (MTDNA) AS A GENETIC SYSTEM FOR TESTING RELATIONSHIP 134
IV. DIVERSITY OF THE CONTROL REGION OF HUMAN MTDNA 136
V. ISOLATION OF MTDNA FROM VARIOUS HUMAN TISSUES 138
VI. TESTING RELATIONSHIPS IN ARGENTINA 139
Acknowledgments 142
References 142
Chapter 4. Molecular Genetics and Drug Discovery 146
I. INTRODUCTION 146
II. THERAPEUTICS PRODUCED BY RECOMBINANT DNA TECHNOLOGY 148
III. SITE-DIRECTED MUTAGENESIS 151
IV. GENETICALLY ENGINEERED DRUG DISCOVERY TOOLS 157
V. FUTURE PROSPECTS 169
Acknowledgments 171
References 171
Chapter 5. The Role of Molecular Biology in Human Evolutionary Studies: Current Status and Future Prospects 182
I. INTRODUCTION 182
II. THE UNIQUE FEATURES OF PRIMATE EVOLUTION 186
III. THE PRIMATE FAMILY TREES 189
IV. TWO EXTREME GENETIC MODELS FOR HUMAN ORIGINS AND EVOLUTION 194
V. HUMAN HISTORY AND THE GENETICS OF REGIONAL TRANSITION 199
VI. MITOCHONDRIA AND HUMAN EVOLUTION 202
VII. WILL IT BE POSSIBLE TO FIND A Y-CHROMOSOME ADAM? 217
VIII. THE EXTENT OF HUMAN DIVERSITY 219
IX. Conclusions 235
References 237
Index 246

Produkt-Details

• Erscheint lt. Verlag: 22.10.2013
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Evolution
• Themenwelt: Naturwissenschaften ► Chemie
• Themenwelt: Technik
• ISBN-10: 1-4832-6205-7 / 1483262057
• ISBN-13: 978-1-4832-6205-5 / 9781483262055