Gastric Secretion (eBook)

Mechanisms and Control

J. A. L. Gilbert, R. C. Harrison, T. K. Shnitka (Herausgeber)

eBook Download: PDF

2016 | 1. Auflage
520 Seiten
Elsevier Science (Verlag)
9781483186177 (ISBN)

Infos

Gastric Secretion: Mechanism and Control covers the proceedings of the symposium held at The Faculty of Medicine, University of Alberta, Edmonton, Canada, on September 13-15, 1965. This compilation mainly focuses on the study of gastric secretion and other biological processes involved. This book is divided into seven parts, beginning with discussions on the anatomy and purpose of gastric mucosa. How the gastrointestinal tract is renewed physiologically is also examined. This text then gives information on the regulation, metabolism, and other biological processes in this organ. This book also specifically explains secretion and its stimulation and inhibition. Parts in this book also tackle gastrin and mucus, as well as the neuro-endocrine control. This text ends with concluding remarks, encouraging further studies of the subject. This selection will be invaluable to students of medicine and biology, as well as specialists of gastrointestinal system.

Inhalt

Front Cover 1
Gastric Secretion: Mechanisms and Control 4
Copyright Page 5
Table of Contents 6
CONTRIBUTORS 10
ACKNOWLEDGEMENTS 14
SYMPOSIUM EDITORS 14
DEDICATION 16
FOREWORD 18
PART I: STRUCTURE AND FUNCTION 20
CHAPTER 1. THE FINE STRUCTURE OF THE GASTRIC MUCOSA 22
SURFACE MUCOUS CELL 22
PARIETAL CELL 25
MUCOUS NECK CELL 32
CHIEF CELL 34
ARGENTAFFIN CELL 36
THE SURFACE COAT 40
REFERENCES 42
CHAPTER 2. MITOTIC HOMEOSTASIS AND PHYSIOLOGICAL CONTROL OF CELL RENEWAL IN HEALTHY AND DISEASED GASTRIC MUCOSA 44
THE DEVELOPMENT OF GASTRIC EPITHELIAL CELLS IN THE FETAL PERIOD 44
PHYSIOLOGICAL RENEWAL 45
HORMONAL INFLUENCE 45
EFFECT OF IRRADIATION 46
CELL RENEWAL IN THE DISEASED STOMACH 46
INTESTINAL METAPLASIA 47
THE CONTROL OF CELL RENEWAL 47
REFERENCES 48
CHAPTER 3. OBSERVATIONS ON THE REGULATION OF THE GROWTH OF THE GASTRIC MUCOSA 52
1. THE INFLUENCES OF AGE, SEX AND BODY WEIGHT 52
2. QUANTITATIVE RELATIONSHIPS BETWEEN THE PARIETAL AND PEPTIC CELL POPULATIONS AND THE VOLUME OF THE GASTRIC MUCOSA 54
3. THE INFLUENCE OF THE PITUITARYGLAND ON THE GROWTH OF THE GASTRIC MUCOSA 55
4.THE EFFECTS OF DUODENAL OBSTRUCTION ON THE GROWTH OF THE GASTRIC MUCOSA IN THE RAT 57
REFERENCES 58
DISCUSSION 59
CHAPTER 4.THE METABOLISM OF GASTRIC MUCOSA DURING THE SECRETION OF HYDROCHLORIC ACID 64
SUMMARY 68
REFERENCES 69
CHAPTER 5. RECENT OBSERVATIONS ON GASTRIC BLOOD FLOW AND ACID SECRETION 72
GENERAL METHODS 72
BLOOD FLOW IN THE CONSCIOUS ANIMAL 75
PHYSIOLOGICAL STIMULI 76
RESPONSE OF THE GASTRIC CIRCULATION TO VARIOUS PHARMACOLOGICAL AGENTS 77
RELATIONSHIP OF GASTRIC BLOOD FLOW TO ACID SECRETION 81
DISTRIBUTION OF BLOOD FLOW WITHIN THE STOMACH 82
THE NEURAL REGULATION OF GASTRIC BLOOD FLOW 83
CONCLUSIONS 85
REFERENCES 85
SUPPLEMENTARY CURRENT REFERENCES 88
DISCUSSION 89
PART II: NEURO-ENDOCRINE CONTROL 92
CHAPTER 6. THE NERVE SUPPLY OF THE STOMACH AND ITS RELATIONSHIP TO SECRETION 94
NERVE SUPPLY OF THE STOMACH 94
NERVOUS AND HORMONALMECHANISMS 97
REFERENCES 100
CHAPTER 7. VAGAL EFFECTS ON GASTRIC SECRETION 102
SUMMARY 107
REFERENCES 108
CHAPTER 8. NEURAL FACTORS IN THE CONTROL OF GASTRIN RELEASE 110
ACKNOWLEDGEMENTS 121
SUMMARY 121
REFERENCES 122
DISCUSSION 124
CHAPTER 9. VAGAL INFLUENCES ON THE GASTRIN CONTENT OF ANTRAL MUCOSA 130
SUMMARY 134
REFERENCES 134
DISCUSSION 136
CHAPTER 10. MAGNITUDE OF THE ANTRUM'S ROLE IN THE CEPHALIC PHASE OF GASTRIC SECRETION 138
METHODS 139
RESULTS 141
DISCUSSION 148
SUMMARY 151
REFERENCES 152
SUPPLEMENTARY CURRENT REFERENCE 152
CHAPTER 11. THE LATE ACID RESPONSE TO INSULIN INDUCED HYPOGLYCAEMIA AND ITS RELATION TO VAGAL STIMULATED GASTRIN RELEASE 154
INTRODUCTION 154
MATERIAL AND METHODS 155
RESULTS 157
REFERENCES 166
CHAPTER 12. HYPOTHALAMIC INFLUENCE ON GASTRIC BLOOD FLOW, CELL COUNTS, ACID AND MUCUS SECRETION—FACTORS IN ULCER PROVOCATION 168
A. HYPOTHALAMIC STIMULATION AND GASTRIC HYDROCHLORIC ACID SECRETION 169
B. AUTONOMIC INFLUENCE ON GASTRIC BLOOD FLOW 172
C. FLOW AND ACID RELATIONSHIPS DURING HISTAMINE INFUSION AND POSTERIOR HYPOTHALAMIC STIMULATION—AN INHIBITORY RESPONSE 175
D.AUTONOMIC INFLUENCE ON GASTRIC TISSUE BLOOD FLOW 176
E.AUTONOMIC INFLUENCE ON GASTRIC CELL POPULATION 178
F.AUTONOMIC INFLUENCE OF GASTRIC MUCUS SECRETION 180
DISCUSSION AND SUMMARY 182
SUMMARY 184
REFERENCES 186
SUPPLEMENTARY CURRENT REFERENCE 187
DISCUSSION 188
PART III: MUCUS 194
CHAPTER 13. REGULATION OF GASTRIC MUCUS SECRETION 196
MATERIALS AND METHODS 197
INFLUENCE OF INTRALUMINAL pH 197
ACTION OF VAGAL STIMULATION 198
INFLUENCE OF MEALS 200
ACTION OF STARVATION 200
INFLUENCE OF THE VARIOUS HUMORAL AGENTS 201
OTHER MISCELLANEOUS HUMORAL AGENTS 202
ANTI-INFLAMMATORY AGENTS 202
PARATHYROID HORMONE 203
CONCLUSIONS AND SUMMARY 203
REFERENCES 204
SUPPLEMENTARY CURRENT REFERENCE 204
CHAPTER 14. FRACTIONATION OF GASTRIC MACROMOLECULAR MATERIALS BY ELECTROPHORESIS, COLUMN CHROMATOGRAPHY AND GEL FILTRATION: CORRELATIVE STUDY 206
ELECTROPHORESIS 208
COLUMN CHROMATOGRAPHY 215
GEL FILTRATION 219
REFERENCES 225
SUPPLEMENTARY CURRENT REFERENCES 228
DISCUSSION 229
CHAPTER 15. STIMULI FOR GASTRIC MUCUS SECRETION 232
REFERENCES 233
CHAPTER 16. MUCUS CONTENT OF GASTRIC JUICE DURING THE SECRETORY PERIOD 234
MATERIAL AND METHODS 234
RESULTS 236
DISCUSSION 240
SUMMARY 242
REFERENCES 243
CHAPTER 17. INTRINSIC FACTOR SECRETION 244
METHODOLOGY 244
THE SITE OF INTRINSIC FACTOR SECRETION 245
INTRINSIC FACTOR SECRETION 248
DERANGEMENTS OF INTRINSIC FACTOR SECRETION 249
ACKNOWLEDGMENT 249
REFERENCES 249
SUPPLEMENTARY CURRENT REFERENCES 250
DISCUSSION 251
PART IV: SECRETION: STIMULATION 258
CHAPTER 18. GASTRIC SECRETION AND DUODENAL ULCER 260
PROTOCOLS 265
INTERPRETATION OF GASTRIC SECRETION TESTS 265
SUMMARY 270
REFERENCES 271
DISCUSSION 273
CHAPTER 19. SOME ASPECTS OF THE HUMORAL MECHANISM OF GASTRIC SECRETION 274
SUMMARY 279
REFERENCES 279
SUPPLEMENTARY CURRENT REFERENCE 280
CHAPTER 20. THE EFFECTS OF TISSUE EXTRACTS ON THE STOMACH 282
ACKNOWLEDGEMENTS 293
SUMMARY 293
REFERENCES 294
DISCUSSION 296
CHAPTER 21. THE ROLE OF INTESTINAL DIGESTION IN THE CONTROL OF ACID SECRETION 302
REFERENCES 310
CHAPTER 22. CONSIDERATIONS ON THE EFFECT OF OBSTRUCTION ON GASTRIC SECRETION 312
ACKNOWLEDGEMENTS 320
SUMMARY 320
REFERENCES 321
SUPPLEMENTARY CURRENT REFERENCE 321
DISCUSSION 322
PART V: GASTRIN 326
CHAPTER 23. THE CONSTITUTION AND PROPERTIES OF GASTRIN 328
STRUCTURE—FUNCTION RELATIONSHIPS IN THE GASTRIN MOLECULE 330
THE CONSTITUTION AND PROPERTIES OF "HUMAN" GASTRIN 333
ACKNOWLEDGEMENT 335
SUMMARY 335
REFERENCES 335
CHAPTER 24. SOME PHYSIOLOGICAL ACTIONS OF GASTRIN 336
SECRETION OF ACID 337
PANCREATIC SECRETION 344
CONCLUSION 347
REFERENCES 347
CHAPTER 25. THE ACTION OF GASTRIN II ON GASTRIC SECRETION OF ELECTROLYTES AND PEPSIN IN MAN 348
A. SUBCUTANEOUS ADMINISTRATION OF GASTRIN 348
B. MAXIMAL SECRETORY CAPACITY 351
C. SECRETORY RESPONSE TO VARIOUS COMBINATIONS OF STIMULANTS 356
D. SYNERGISM BETWEEN GASTRIN AND CHOLINERGIC AGENTS 358
E.CELLULAR MASSES AND SECRETORY OUTPUT 359
F. GASTRIC SECRETORY RATE AND ELECTROLYTE CONCENTRATION FOLLOWING STIMULATION BY GASTRIN 361
SUMMARY 363
REFERENCES 363
SUPPLEMENTARY CURRENT REFERENCE 364
DISCUSSION 365
CHAPTER 26. ACTION OF PURIFIED GASTRIN POLYPEPTIDE ON THE ISOLATED GASTRIC MUCOSA OF THE BULLFROG 370
SUMMARY 373
REFERENCES 374
DISCUSSION 375
CHAPTER 27. FAILURE OF GASTRIN INACTIVATION BY THE LIVER 376
METHODS AND RESULTS 376
DISCUSSION 378
SUMMARY 379
REFERENCES 380
CHAPTER 28. FURTHER OBSERVATIONS ON FACTORS INFLUENCING THE SYMPTOMATOLOGY MANIFEST BY PATIENTS WITH THE ZOLLINGER–ELLISON SYNDROME* 382
THE RELATIVE IMPORTANCE OF GASTRIC HYPERACIDITY AND THE VARIED RESPONSE OF THE PATIENT 383
MAXIMAL HISTAMINE SECRETION AS AN AID TO DIAGNOSIS 384
THE PARIETAL CELL MASS IN THE ZOLLINGER-ELLISON SYNDROME 384
PATHOGENESIS OF DIARRHEA IN ULCEROGENIC TUMORS OF THE PANCREAS 385
METABOLICE FFECTS OF GASTRIN 387
REFERENCES 388
DISCUSSION 389
PART VI: SECRETION: INHIBITION 394
CHAPTER 29. THE RECOGNITION AND ASSAY OF GASTRONE 396
BACKGROUND 396
QUANTITATIVE DETERMINATION OF GASTRONE 410
COMMENT 420
SUMMARY 420
REFERENCES 421
SUPPLEMENTARY CURRENT REFERENCES 423
CHAPTER 30. FRACTIONATION OF ENDOGENOUS INHIBITORS OF GASTRIC SECRETION (GASTRONE) BY PHYSICO-CHEMICAL MEANS 424
FRACTIONATION BY CONTINUOUS ELECTROPHORESIS ON PAPER CURTAIN 424
FRACTIONATION ON AMBERLITE IRC-50 (XE-64) COLUMNS 427
FRACTIONATION BY COHN'S METHOD No.10 429
FRACTIONATION BY STEPWISE PRECIPITATION OF THE GASTRIC JUICE 430
FRACTIONATION OF GASTRIC JUICE BY GEL FILTRATION ON SEPHADEX COLUMNS 432
CHROMATOGRAPHY ON DEAE-SEPHADEX A-50 COLUMN 434
FRACTIONATION OF INHIBITORY MATERIALS FROM HUMAN SERUM ON DEAE-SEPHADEX A-50 COLUMNS 438
DISCUSSION 439
SUMMARY AND CONCLUSIONS 442
REFERENCES 443
DISCUSSION 445
CHAPTER 31. DUODENAL INHIBITION OF GASTRIC SECRETION 448
SUMMARY 455
REFERENCES 456
CHAPTER 32. ENDOCRINE AND EXOCRINE STUDIES ON HOMOTRANSPLANTED GASTRIC POUCHES 458
INTRODUCTION 458
MATERIALS AND METHODS 459
RESULTS 466
DISCUSSION 476
SUMMARY 482
REFERENCES 482
SUPPLEMENTARY CURRENT REFERENCE 484
DISCUSSION 485
CHAPTER 33. ENTEROGASTRONE—A REAPPRAISAL 
488 
SUMMARY 495
REFERENCES 495
SUPPLEMENTARY CURRENT REFERENCES 496
DISCUSSION 497
PART VII: CONCLUDING REMARKS 500
CHAPTER 34. CONCLUDING REMARKS 502
BIBLIOGRAPHY 504
HISTORICAL 504
MODERNERA 504
CURRENT MONOGRAPHS 505
INDEX 506

Produkt-Details

• Erscheint lt. Verlag: 21.1.2016
• Sprache: englisch
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• ISBN-13: 9781483186177 / 9781483186177