Single-Molecule Fluorescence Spectroscopy of the Folding of a Repeat Protein
Springer International Publishing (Verlag)
978-3-319-09557-8 (ISBN)
In
this thesis single-molecule fluorescence resonance energy transfer
(FRET)
spectroscopy was used to study the folding of a protein that belongs
to the large and important family of repeat proteins. Cohen shows
that the dynamics of the expanded conformations is likely to be very
fast, suggesting a spring-like motion of the whole chain. The
findings shed new light
on the elasticity of structure in repeat proteins, which is related
to their function in binding multiple and disparate partners. This
concise research summary provides useful insights for students
beginning a PhD in this or a related area, and researchers entering
this field.
Sharona Cohen is a trained physicist, specialized in optical systems, microscopy and spectroscopy. She acquired her PhD at the interdisciplinary chemical physics department at Weizmann Institute of Science.
Abstract.- Introduction.- Methods.- Results.- Discussion.- Summary and Future Plans.
| Erscheint lt. Verlag | 2.11.2015 |
|---|---|
| Reihe/Serie | Springer Theses |
| Zusatzinfo | XIII, 59 p. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Schlagworte | Consensus TPR (CTPR) • CTPR with Three Repeats (CTPR3) • Fluorescent Correlation Spectroscopy (FCS) • Förster Resonance Energy Transfer (FRET) • Repeat Proteins • Single Molecule FRET (SM-FRET) • Tetratrico Peptide Repeat (TPR) |
| ISBN-10 | 3-319-09557-9 / 3319095579 |
| ISBN-13 | 978-3-319-09557-8 / 9783319095578 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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