Aspartic ProteinasesPhysiology and Pathology
Crc Press Inc (Verlag)
978-0-8493-7660-3 (ISBN)
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Aspartic Proteinases: Physiology and Pathology focuses on the advantages and limitations of the use of proteinases and their inhibitors in human pathology. A virus-specific aspartic proteinase enzyme is required for the maturation of a virus. If the enzyme can be eliminated, so can the maturation of the virus. This book reviews the wealth of recently published information sparked by the renewed interest in these enzymes.
INTRODUCTION
ASPARTIC PROTEINASES-AN OVERVIEW
Aspartic Proteinases
Family of Aspartic Proteinases-Characteristic Properties
Evolution of Aspartic Proteinases-Their Primary, Secondary, and Tertiary Structures
Catalytic Mechanism of Aspartic Proteinases
Specificity of the Proteinase Action
Inhibition of Aspartic Proteinases
Propeptides of Aspartic Proteinases and Activation of Zymogens
Concluding Remarks
PEPSIN A AND GASTRICSIN AND THEIR ZYMOGENS
Introduction
Nomenclature
Localization of Pepsin A and Gastricsin and Their Physiological Role
Localization of Pepsinogen A and Progastricsin in the Human Body
Intracellular Synthesis of Pepsinogen A and Progastricsin
Secretion of Pepsinogen A and Progastricsin
Activation of Zymogens
Age Dependent Changes in Gastric Enzyme
Seminal Progastricsin
Sequence and Expression
Sequences-Pepsinogen A and Progastricsin
Polymorphism of Pepsinogen A and Progastricsin
Three-Dimensional Structure
Overall Shape-Pepsinogen A
Phosphoserine 68
Active Site
Comparison of Pepsin and Pepsinogen Structures
Proteolytic Activity
Pepsin A and Gastricsin and Patho-Physiological Conditions
Determination of Serum Pepsinogen and Gastricsin
Normal Levels
Serum Pepsinogen A and Progastricsin and Patho-Physiological States
Concluding Remarks
RENIN
Introduction
Localization, Secretion, and Physiological Function of Renin
Localization of Renin and Prorenin
Mammalian Secretory Pathways and Regulation of Renin Secretion
The Proteolytic Cleavage of Angiotensinogen-Basic Physiological Function of Renin
Sequence and Posttranslational Modifications
Gene Structure
Primary Structure
The Posttranslational Modifications
Three-Dimensional Structure
Overall Shape
Active Site
Specificity of Renin Catalysis
The Clinical Potential of Renin Inhibition
Introduction
Renin Specific Antibodies
Synthetic Renin Inhibitors
Pharmacology of Renin Inhibition
Concluding Remarks
CATHEPSIN D
Introduction
Physiological Functions
Intracellular Catabolism
Processing of Antigens and Peptide Hormones
Tissue Remodeling
Sequence and Regulation of Expression
Sequence of Cathepsin D
Regulation of the Expression
Cellular Targeting, Processing and Localization of Cathepsin D
Targeting of Cathepsin D to the Lysosomes
Posttranslational Modifications of Cathepsin D
Localization of Cathepsin D
Three-Dimensional Structure
Overall Shape, Processed Loop
Targeting, Recognition Signal
The Active Site
Catalytic Properties
Characterization of Subsite Preferences
Patho-Physiological Involvement of Cathepsin D
Involvement of Cathepsin D in Neurodegenerative Diseases
Involvement of Cathepsin D in Neoplastic Diseases
Conclusions
CATHEPSIN E
Introduction
Localization of Cathepsin E
Subcellular Localization of Cathepsin E
Physiologic Function
Primary Structure of Cathepsin E and its Molecular Forms
Catalytic Properties of Cathepsin E
Cathepsin E and Gastric Cancers
Concluding Remarks
ASPARTIC PROTEINASES OF CANDIDA YEASTS
Introduction
Candida Yeasts: An Opportunistic Pathogen
The Aspartic Proteinase: Virulence Factor of Candidal Infections
The Biochemistry of Candida Aspartic Proteinases
Conditions for Proteinase Secretion-Induction by Substrate and pH
Complex Genetic of Candida Aspartic Proteinases and Their Primary Structures
Three-Dimensional Structures of Candida Aspartic Proteinases
Specificity of Proteinases and Inhibitor Design
Concluding Remarks
ASPARTIC PROTEINASE OF PLASMODIUM FALCIPARUM
Introduction
The Life-Cycle of Plasmodium falciparum Parasite
The Production of Aspartic Proteinase
Sequence of Plasmodium Aspartic Proteinases
Specificity of the Proteinases and Inhibitors
HIV AND RETROVIRAL PROTEINASES
Principles of HIV Infection
Introduction
HIV Genome
Immunopathogenesis
HIV Interaction with Myeloid Cells
Role of B Lymphocytes
Activation of Latent Infection
Immune Response
Retroviral Aspartic Proteinases-Members of the Family of Aspartic Proteinases
Similarity of Retroviral Proteinases with Eucaryotic Enzymes
Biochemical and Molecular Biology Studies on Similarity of the Two Types of Proteinases
Three-Dimensional Structures of the Two Types of Aspartic Proteinases
Three-Dimensional Structures of Retroviral Aspartic Proteinases
Methods of Preparation of Retroviral Proteinases
Structural Features of Retroviral Proteinases
Catalytic Properties of Retroviral Proteinases
Inhibitors of Retroviral Proteinases and Design of Drugs for AIDS Treatment
Overview of HIV Proteinase Inhibitors
Mode of Binding of Inhibitors
High Rate of Resistant Mutants Appearance-Problem of HIV Drug Design
Concluding Remarks
Appendix
Index
| Erscheint lt. Verlag | 23.10.1995 |
|---|---|
| Zusatzinfo | 16 Tables, black and white |
| Verlagsort | Bosa Roca |
| Sprache | englisch |
| Maße | 156 x 235 mm |
| Gewicht | 680 g |
| Einbandart | gebunden |
| Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| Naturwissenschaften ► Biologie ► Biochemie | |
| ISBN-10 | 0-8493-7660-2 / 0849376602 |
| ISBN-13 | 978-0-8493-7660-3 / 9780849376603 |
| Zustand | Neuware |
| Informationen gemäß Produktsicherheitsverordnung (GPSR) | |
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