Pancreatic Islet Cell Regeneration and Growth

Buch | Softcover

187 Seiten

2012 | Softcover reprint of the original 1st ed. 1992
Springer-Verlag New York Inc.
978-1-4613-6526-6 (ISBN)

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Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.

Section One - Regulation Of Cell Growth And Development.- The Role of Growth Hormone and Prolactin in Beta-Cell Growth and Regeneration.- The Insulin-Like Growth Factor Family of Peptides, Binding Proteins and Receptors: Their Potential Role in Tissue Regeneration.- The Effects of IGF-I and IGF-II on Cell Growth and Differentiation in the Central Nervous System.- Growth Factor Expression in Normal and Diabetic Rats During Peripheral Nerve Regeneration through Silicone Tubes.- Oncogenes and Cell Growth.- Interferon - A Candidate Mediator of Cell Growth.- Section Two - Models for the Study of Cell Regeneration.- Islet Beta-Cell Regeneration and Reg Genes.- Factors Regulating Islet Regeneration in the Post-Insulinoma NEDH Rat.- Regeneration of Pancreatic Endocrine Cells in Interferon Gamma Transgenic Mice.- Trophic Stimulation of the Ductular-Islet Cell Axis: A New Approach to the Treatment of Diabetes.- Section Three - Induction of Cell Growth and Mechanisms.- Expression of Insulin-Like Growth Factors (IGFs) and Their Binding Proteins (IGF BPs) During Pancreatic Development in Rat, and Modulation of IGF Actions on Rat Islet DNA Synthesis by IGF BPs.- The Partial Isolation and Characterization of Ilotropin, A Novel Islet-Specific Growth Factor.- Expression of Growth Factors in a Pancreatic Islet Regeneration Model.- Role of p21ras in Hormone Signalling and Cell Growth Transformation.- Phosphoinositides and Cell Growth.- The Physiological STOP Pathway: Target Regulation of Axonal Growth.- Cell Calcium Regulation of Myosin I - A Motor for Membrane Movement.- Section Four - Pathogenic and Therapeutic Ramifications.- Amylin Expression in the Pancreatic Beta-Cell.- Studies of Composite Grafts of Fetal Pancreas (FP) and Fetal Liver (FL) in the Streptozotocin-Induced Diabetic Rat.- Contributors.

Reihe/Serie	Advances in Experimental Medicine and Biology ; 321
Zusatzinfo	IX, 187 p.
Verlagsort	New York, NY
Sprache	englisch
Maße	170 x 244 mm
Themenwelt	Medizin / Pharmazie ► Gesundheitswesen
	Medizinische Fachgebiete ► Innere Medizin ► Diabetologie
	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	1-4613-6526-0 / 1461365260
ISBN-13	978-1-4613-6526-6 / 9781461365266
Zustand	Neuware