Carbohydrate Recognition (eBook)

Biological Problems, Methods, and Applications

Binghe Wang, Geert-Jan Boons (Herausgeber)

eBook Download: PDF

2011
John Wiley & Sons (Verlag)
978-1-118-01756-2 (ISBN)

Infos

This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Autor

BINGHE WANG, PHD, is Professor and Chair of the Department of Chemistry at Georgia State University as well as Georgia Research Alliance Eminent Scholar in Drug Discovery. He is Editor-in-Chief of the journal Medicinal Research Reviews, Series Editor for the Wiley Series in Drug Discovery and Development, and editor of Drug Delivery: Principles and Applications and Chemosensors: Principles, Strategies, and Applications (Wiley). GEERT-JAN BOONS, PHD, is Franklin Professor of Chemistry and Professor in the Complex Carbohydrate Research Center at the University of Georgia. He is on the editorial boards of several journals on carbohydrates, including European Journal of Chemistry and Journal of Carbohydrate Chemistry, and is also coeditor of Carbohydrate-Based Immunotherapies and Vaccines (Wiley).

Inhalt

CARBOHYDRATE RECOGNITION 3
PREFACE 9
CONTRIBUTORS 11
1 MAMMALIAN GLYCAN BIOSYNTHESIS: BUILDING A TEMPLATE FOR BIOLOGICAL RECOGNITION 13
2 THE ROLES OF CARBOHYDRATE BINDING IN CELL ADHESION AND INFLAMMATION 45
3 THE ROLE OF CARBOHYDRATES IN VIRAL INFECTIONS 77
4 THE ROLE OF CARBOHYDRATES IN BACTERIAL INFECTIONS 105
5 THE ROLES OF CARBOHYDRATE BINDING IN FERTILIZATION 119
6 CARBOHYDRATE BIOMARKERS 145
7 GALECTINS AND THEIR ROLE IN VARIOUS BIOLOGICAL PROCESSES 169
8 GLYCOIMMUNOLOGY 193
9 TOOLS FOR GLYCOMICS: GLYCAN AND LECTIN MICROARRAYS 217
10 COMBINATORIAL BIOSYNTHESIS OF COMPLEX CARBOHYDRATES 241
11 MASS SPECTROMETRY IN CARBOHYDRATE SEQUENCING AND BINDING ANALYSIS 269
12 SYNTHETIC LECTIN MIMICS ARTIFICIAL CARBOHYDRATE RECEPTORS 313
13 LECTIN BINDING AND ITS STRUCTURAL BASIS 341
14 MULTIVALENCY IN CARBOHYDRATE BINDING 361
15 CARBOHYDRATE BINDING AGENTS: POTENTIAL THERAPEUTICS WITH MULTIPLE INHIBITORY ACTIONS AGAINST ENVELOPED VIRUSES 383
16 INFORMATICS FOR GLYCOBIOLOGY AND GLYCOMICS 421
INDEX 439

Produkt-Details

• Erscheint lt. Verlag: 26.7.2011
• Reihe/Serie: Wiley series in drug discovery and development
• Reihe/Serie: Wiley series in drug discovery and development
• Reihe/Serie: Wiley Series in Drug Discovery and Development
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Chemie
• Schlagworte: Applications • around • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Book • Brings • Carbohydrate • carbohydrates • cellular • Chemie • Chemistry • Chemists • Contributions • Drug Discovery & Development • Identification • Information • Interdisciplinary • Issue • Medical Science • Medizin • Number • One • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Place • Recognition • scientists • Wealth • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung • World
• ISBN-10: 1-118-01756-0 / 1118017560
• ISBN-13: 978-1-118-01756-2 / 9781118017562