Stem Cell-Dependent Therapies

Mesenchymal Stem Cells in Chronic Inflammatory Disorders

Gerhard Gross, Thomas Häupl (Herausgeber)

Media-Kombination

XVIII, 408 Seiten | Ausstattung: Hardcover & eBook

2013
De Gruyter
978-3-11-029831-4 (ISBN)

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Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.

Gerhard Gross, Helmholtz Centre for Infection Research, Braunschweig, Germany; Thomas Häupl, Charité, Berlin, Germany.

Co-Autor	Graca Almeida-Porada, Leo Bühler, Niels Olsen Saraiva Camara, Pierre Charbord, Yves A. DeClerck, James E. Dennis, Carmen Gonelle-Gispert, Jens Kastrup, Andreas Kurtz, Antonello Pileggi, Mauricio Rojas, Olle Ringdén, Alan Tyndall, Antonio Uccelli, Daniel Weiss, David Wraith, Jian Wu
Zusatzinfo	Includes a print version and an ebook
Verlagsort	Berlin/Boston
Sprache	englisch
Maße	170 x 240 mm
Themenwelt	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
Schlagworte	Autoimmune disorders • Autoimmune Disorders; Immunomodulation; Inflammation; Regenerative Medicine; Stem Cells • Autoimmunkrankheit • Chronische Entzündung • Immunomodulation • inflammation • Regenerative medicine • Regenerative Medizin • Stammzellen • Stem Cells
ISBN-10	3-11-029831-7 / 3110298317
ISBN-13	978-3-11-029831-4 / 9783110298314
Zustand	Neuware