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Molecular Genetics of Mental Disorders

The Place of Molecular Genetics in Basic Mechanisms and Clinical Applications in Mental Disorders

Mike Briley, Fridolin Sulser (Autoren)

Buch | Hardcover

354 Seiten

2000
Informa Healthcare (Verlag)
978-1-85317-917-4 (ISBN)

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The field of molecular genetics is undergoing an explosion, not only in its fundamental understanding of the genetic processes but also in the potential applications as research tools and therapeutic approaches to many disease areas. Mental disorders are no exception and it is likely that most new psychotropic drugs will in future be derived through molecular genetic approaches. This book examines the place of molecular genetics in our understanding of the basic mechanisms of mental disorders and their role in highlighting new drug targets.

1. Characterization of Expression Profiles of Genes Involved in Brain Functions by Quantitative Hybridization of High-Density DNA Arrays 2. Differential Display for Detecting Potential Gene Candidates 3. Molecular Psychopharmacology as a Prelude to a Molecular Psychopathology of Affective Disorders: The Significance of Differential Display Methodology to Study Programs of Gene Expression 4. Diverse Signalling Via a 5. The Knockout Mouse: Pharmacological Tool or Model of Psychiatric Disorder 6. The Orphan Receptor Strategy and the Discovery of Novel Neuropeptides 7. Antisense: A Genetic Approach to Depression 8. Characterization of 5-HT-Moduline Through an Integrated Use of Molecular Genetic Tools 9. Validation of the a 10. Acetylcholinesterase Variants in Mammalian Stress: Catalytic Short-Term and Structural Long-Term Roles 11. Modification of Gene Expression in the Mechanism of Action of Antipsychotic Drugs 12. Regulation of Neural Plasticity by Stress and Antidepressant Treatment 13. Genetic Variation and Alternative Splicing of 5-HT Receptors : Potential Role in Neuropsychiatric Diseases and Modification of Pharmacolog ical and Functional Properties 14. Polymorphisms of the Enzymes Involved in Monoamine Synthesis 15. Serotonin Transporter: From Genomics and Knockouts to Behavioral Traits and Psychiatric Disorders 16. Transcription Factors in the Development of the Mesencephalic Dopamine System 17. Pharmacogenomics of Schizophrenia 18. Relationship Between ApolipoproteinE and Susceptibility to Neurodegenerative Disease

Zusatzinfo	40 Illustrations, black and white
Sprache	englisch
Maße	187 x 235 mm
Gewicht	939 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Psychiatrie / Psychotherapie
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
ISBN-10	1-85317-917-5 / 1853179175
ISBN-13	978-1-85317-917-4 / 9781853179174
Zustand	Neuware