Enzyme Technologies – Metagenomics, Evolution, Biocatalysis and Biosynthesis

Wu-Kuang Yeh, Hsiu-Chiung Yang, James R. McCarthy (Herausgeber)

Software / Digital Media

388 Seiten

2011
Wiley-Blackwell (Hersteller)
978-0-470-62730-3 (ISBN)

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Enzyme Technologies in Drug Discovery highlights how, what, and where enzymes have become critical in pharmaceutical and biotechnology research. This book provides in-depth reviews of recent developments in biosynthesis, biocatalysis, and the chemical biology of enzymes. This text discusses enzymatic assays, including emerging assay technologies for key enzyme classes in pharmaceutical research. In addition to new developments in proteomics, this book includes two emerging technologies in life sciences, metabolomics and preclinomics. This volume reviews important progress on the chemical biology of enzymes in the post-genomic era.

Wu-Kuang Yeh , PhD, is Executive Consultant and was director of research and principal investigator at PreClinOmics, Inc., from 2004-2010. He was a principal research scientist at Eli Lilly and Company from 1982-2004. He is the author or coauthor of over 115 abstracts and publications, coeditor of one book, and the holder of six U.S. patents. Hsiu-Chiung Yang , PhD, is a Research Advisor at Eli Lilly and Company. She was a principal research scientist at Eli Lilly and Company from 1998-2007 and is the author or coauthor of over forty abstracts and publications, as well as co-inventor of one patent. James R. Mccarthy , PhD, is the author, coauthor, or coeditor of over 125 scientific publications and holder of over forty U.S. patents. He is on the editorial advisory board of the Journal of Medicinal Chemistry and is a past chair of the division of Medicinal Chemistry of the American Chemical Society. He also serves as a Senior Scientific Advisor for the Huntington Disease Research Foundation.

Contributors. Preface. PART A NEW APPROACHES TO FINDING AND MODIFYING ENZYMES. 1 Functional Metagenomics as a Technique for the Discovery of Novel Enzymes and Natural Products ( Luke A. Moe, Matthew D. McMahon, and Michael G. Thomas ). 2 Directed Enzyme and Pathway Evolution ( Jacob Vick and Claudia Schmidt-Dannert ). 3 Combining Natural Biodiversity and Molecular-Directed Evolution to Develop New Industrial Biocatalysts and Drugs ( Laurent Fourage, Celine Ayrinhac, Johann Brot, Christophe Ullmann, Denis Wahler, and Jean-Marie Sonet ). 4 Principles of Enzyme Optimization for the Rapid Creation of Industrial Biocatalysts ( Richard J. Fox and Lori Giver ). PART B BIOCATALYTIC APPLICATIONS. 5 Enzyme Catalysis in the Synthesis of Active Pharmaceutical Ingredients ( Animesh Goswami ). 6 Enzymatic Processes for the Production of Pharmaceutical Intermediates ( David Rozzell and Jim Lalonde ). 7 Novel Developments Employing Redox Enzymes: Old Enzymes in New Clothes ( Kurt Faber, Silvia M. Glueck, Birgit Seisser, and Wolfgang Kroutil ). PART C BIOSYNTHETIC APPLICATIONS. 8 Drug Discovery and Development by Combinatorial Biosynthesis ( Matthew A. DeSieno, Carl A. Denard, and Huimin Zhao ). 9 Reprogramming Daptomycin and A54145 Biosynthesis to Produce Novel Lipopeptide Antibiotics ( Richard H. Baltz, Kien T. Nguyen, and Dylan C. Alexander ). 10 Pathway and Enzyme Engineering and Applications for Glycodiversification ( Lishan Zhao and Hung-wen Liu ). Index.

Erscheint lt. Verlag	25.5.2011
Verlagsort	Hoboken
Sprache	englisch
Maße	150 x 250 mm
Gewicht	666 g
Themenwelt	Naturwissenschaften ► Chemie
Themenwelt	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	0-470-62730-1 / 0470627301
ISBN-13	978-0-470-62730-3 / 9780470627303
Zustand	Neuware