Cholesterol Regulation of Ion Channels and Receptors

I Levitan (Autor)

Software / Digital Media

302 Seiten

2012
John Wiley & Sons Inc (Hersteller)
978-1-118-34231-2 (ISBN)

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This book brings together the most up-to-date knowledge about the role of cholesterol in regulation of ion channels and receptors and the pathological implications of these effects. It provides a comprehensive critical overview of the field comprised of three sections focusing on theimpact of cholesterol on membrane structure, cholesterol regulation of ion channels and cholesterol regulation of receptors. This resource stands as a primary source of information for researchers both in academia and industrial drug development alike.

IRENA LEVITAN, PhD , is Associate Professor of Medicine at the University of Illinois College of Medicine at Chicago. Her research interests focus on the impact of dyslipidemia on K+ channels and endothelial biomechanics. FRANCISCO J. BARRANTES is the former head of the National Research Council (CONICET) -- Bahia Blanca and UNESCO Chair of Biophysics and Molecular Neurobiology. Currently, he is Director of the Laboratory of Molecular Neurobiology and Professor at the Faculty of Medical Sciences, Pontifical Catholic University of Argentina. His current research interests focus on the understanding of nicotinic acetylcholine receptor-membrane cross-talk.

FOREWORD vii PREFACE ix CONTRIBUTORS xi I CHOLESTEROL REGULATION OF MEMBRANE PROPERTIES 1 1 CHOLESTEROL TRAFFICKING AND DISTRIBUTION BETWEEN CELLULAR MEMBRANES 3 Daniel Wu¨ stner, Lukasz Michael Solanko, and Frederik W. Lund 2 CHOLESTEROL REGULATION OF MEMBRANE PROTEIN FUNCTION BY CHANGES IN BILAYER PHYSICAL PROPERTIES--AN ENERGETIC PERSPECTIVE 27 Jens A. Lundbaek and Olaf S. Andersen II CHOLESTEROL REGULATION OF ION CHANNELS 45 3 INSIGHTS INTO STRUCTURAL DETERMINANTS OF CHOLESTEROL SENSITIVITY OF KIR CHANNELS 47 Avia Rosenhouse-Dantsker and Irena Levitan 4 ROLE OF LIPID RAFTS IN THE REGULATION OF STORE-OPERATED CA2+ CHANNELS 69 Hwei L. Ong and Indu S. Ambudkar 5 CHOLESTEROL REGULATION OF CARDIAC ION CHANNELS 91 Elise Balse, Ste' phane Hatem, and Stanley Nattel 6 DIFFERENTIAL CONTRIBUTION OF BK SUBUNITS TO NONGENOMIC REGULATION OF CHANNEL FUNCTION BY STEROIDS 109 Alex M. Dopico, Anna N. Bukiya, and Aditya K. Singh 7 REGULATION OF K+ CHANNELS BY CHOLESTEROL-RICH MEMBRANE DOMAINS IN THE IMMUNE SYSTEM 135 Nu' ria Comes and Antonio Felipe 8 INDIRECT CHANNEL REGULATION BY CHOLESTEROL: THE ROLE OF CAVEOLAE AND CAVEOLINS IN REGULATING KATP CHANNEL FUNCTION 161 Caroline Dart III CHOLESTEROL REGULATION OF RECEPTORS 181 9 REGULATION OF THE NICOTINIC ACETYLCHOLINE RECEPTOR BY CHOLESTEROL AS A BOUNDARY LIPID 183 Francisco J. Barrantes 10 SPECIFIC AND NONSPECIFIC REGULATION OF GPCR FUNCTION BY CHOLESTEROL 205 Gerald Gimpl and Katja Gehrig-Burger 11 STRUCTURAL INSIGHTS INTO CHOLESTEROL INTERACTIONS WITH G-PROTEIN-COUPLED RECEPTORS 231 Jeremiah S. Joseph, Enrique E. Abola, and Vadim Cherezov 12 MEMBRANE CHOLESTEROL: IMPLICATIONS IN RECEPTOR FUNCTION 255 Sandeep Shrivastava and Amitabha Chattopadhyay 13 THE ROLE OF CHOLESTEROL AND LIPID RAFTS IN REGULATION OF TLR RECEPTORS 273 Ruxana T. Sadikot INDEX 281

Erscheint lt. Verlag	22.6.2012
Verlagsort	New York
Sprache	englisch
Maße	172 x 244 mm
Gewicht	666 g
Themenwelt	Naturwissenschaften ► Biologie
	Naturwissenschaften ► Chemie
	Naturwissenschaften ► Physik / Astronomie
ISBN-10	1-118-34231-3 / 1118342313
ISBN-13	978-1-118-34231-2 / 9781118342312
Zustand	Neuware