Nanotechnology for the Delivery of Therapeutic Nucleic Acids

Dan Peer (Herausgeber)

Buch | Hardcover

240 Seiten

2013
Pan Stanford Publishing Pte Ltd (Verlag)
978-981-4411-04-2 (ISBN)

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Nucleic acid (NA) therapeutics has been extensively studied both in the academia and in the pharmaceutical industry and is still considered the promise for new therapeutic modalities, especially in personalized medicine. The only hurdle that limits the translation of NA therapeutics from an academic idea to the new therapeutic modality is the lack of efficient and safe delivery strategies.

Nanotechnology for the Delivery of Therapeutic Nucleic Acids, written by world experts in the field of nanotechnology for NA delivery, the contributing authors bring together the state of the art in delivery strategies with strong emphasis on aspects that are of essence to the pharmaceutical industry, such as stability, general toxicity, immune-toxicity, pharmacokinetics, efficacy, and validation of new drug targets using unique approaches based on exquisite nanotechnology strategies.

Dan Peer is an associate professor and head of the laboratory of NanoMedicine at Tel Aviv University. His research was one of the first to demonstrate the systemic delivery of RNAi using targeted nanocarriers to the immune system and the first to demonstrate the in vivo validation of new drug targets using RNAi in the immune system. Prof. Peer has authored and edited several books on biomaterials and nanomedicine. He is on the editorial board of several journals, including Nanotechnology, Journal of Controlled Release, Journal of Biomedical Nanotechnology, Biomedical Microdevices, and Cancer Letters.

Lipoplexes and Polyplexes: From Gene Delivery to Gene Expression. Cationic Polymers for the Delivery of Therapeutic Nucleotides. Membrane/Core Nanoparticles for Delivery of Therapeutic Nucleic Acid. Delivery of Single siRNA Molecules. Cell-Specific Aptamer-Functionalized RNAi: A New Prospect for Targeted siRNA Delivery. Bioresponsive Nanoparticles for the Intracellular Delivery of RNAi Therapeutics. Lipid-Like Delivery Materials for Efficient siRNA Delivery. Manipulation of Leukocytes Using Therapeutic RNAi Delivered by Targeted and Stabilized Nanoparticles. Lowering the siRNA Delivery Barrier: Alginate Scaffolds and Immune Stimulation.

Erscheint lt. Verlag	2.4.2013
Zusatzinfo	9 Illustrations, color; 30 Illustrations, black and white
Verlagsort	Singapore
Sprache	englisch
Maße	152 x 229 mm
Gewicht	464 g
Themenwelt	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften
	Technik ► Maschinenbau
	Technik ► Medizintechnik
	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	981-4411-04-3 / 9814411043
ISBN-13	978-981-4411-04-2 / 9789814411042
Zustand	Neuware