Progress in Toxicology

Special Topics Volume 2

Gerhard Zbinden (Autor)

Buch | Softcover

VI, 120 Seiten

2011
Springer Berlin (Verlag)
978-3-642-66293-5 (ISBN)

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THE STATE OF THE ART The recent seventies have not been good times for toxicologists. Public confidence in us is shaken, mostly as a consequence of an unhappy sequence of spectacular failures: we have been surprised by a tragic transplacental carcinogenic effect of diethylstilbestrol, an old and widely prescribed synthetic estrogen. We are confronted with a small epidemic of an unusual liver tumor, angiosarcoma, induced by a simple chemical, vinylchloride, whose insiduous toxic potential we failed to "recognize for years. Our clinical colleagues had to tell us about the ulcerogenic effect of as simple a substance as potassium chloride. We also just learned of an unusual toxic reaction, pseudolupus, developing in people taking a popular fixed-combination drug, venocuran~ Admit tedly, we could not have predicted this syndrome, even if we had con sidered the possibility. We are still unable (to continue this self-flagellation) to explain the relationship between the appetite suppressant arninorex and the sud denly increased occurrence of a lung disease posing as primary pulmonary hypertension. And worse yet, we have no way to evaluate a new deriva tive of this class, and to predict whether or not it, too, will produce the deadly condition. We still, to my knowledge, have no plausible ex planation why and how thalidomide caused phocomelia. Of course, we do diligently a set of teratological experiments with each new drug; we follow a protocol which has the blessing of all governmental regulatory agencies.

I. Introduction.- The State of the Art.- The Trial.- II. Formal Toxicology.- The Role of Pathology in Toxicity Testing.- Drug Combinations - Drug Interactions.- III. Speculative Toxicology.- Drug-induced Lipidosis.- IV. Comperative and Pharmacokinetic Toxicology.- General Remarks.- Urinary pH.- Percutaneous Drug Permeation.- Glutathione.- V. Pharmacodynamic Toxicology.- Hyperglycemia.- VI. Symptomatic Toxicology.- Pseudolupus.- Health Hazards from Colors.- References.

Erscheint lt. Verlag	24.11.2011
Zusatzinfo	VI, 120 S. 1 Abb.
Verlagsort	Berlin
Sprache	deutsch
Maße	178 x 254 mm
Gewicht	256 g
Themenwelt	Naturwissenschaften ► Chemie
Schlagworte	Droge • Forschung • Toxicology • Toxikologie
ISBN-10	3-642-66293-5 / 3642662935
ISBN-13	978-3-642-66293-5 / 9783642662935
Zustand	Neuware