Solid–Phase Organic Syntheses Volume 2 – Solid–Phase Palladium Chemistry

P Scott (Autor)

Software / Digital Media

184 Seiten

2012
John Wiley & Sons Inc (Hersteller)
978-1-118-33695-3 (ISBN)

Infos

This series informs researchers of major accomplishments in solid-phase organic synthesis and provides actual experimental details and specific references. With this series, a reader will be able to sharpen hands-on skills by following the experimental procedures and refining understanding of the science by studying the chosen reactions. More importantly, this series guides readers in designing novel compound libraries, and may also inspire future breakthroughs. This second volume focuses on palladium chemistry in solid-phase synthesis, and discusses: palladium catalysts and reactions, procedures for preparation and utilization, ligands, and linker reactions.

Autor

PETER J. H. SCOTT is an Assistant Professor in the Department of Radiology at the University of Michigan Medical School. Dr. Scott edited Linker Strategies in Solid-Phase Organic Synthesis (also from Wiley) and is the Series Editor for both the Wiley Series on Radiochemical Syntheses and the Wiley Series on Solid-Phase Organic Syntheses.

Inhalt

Contributors ix Preface xiii Abbreviations xv PART I INTRODUCTION 1 1. An Introduction to Solid-Phase Palladium Chemistry 3 Carmen Gil PART II PALLADIUM-MEDIATED SPOS 23 2. Pd-Catalyzed Solid-Phase Decoration of the 2(1H)-Pyrazinone Scaffold 25 Vaibhav P. Mehta and Erik V. Van der Eycken 3. One-Step Palladium- and Phenylsilane-Activated Amidation of Solid-Supported Ally Esters 35 Zheming Ruan, Katy Van Kirk, Christopher B. Cooper, R. Michael Lawrence, and Michael Poss 4. Solid-Phase Reactions of Polymer-Bound Arenesulfonates with Aryl Grignard Reagents 41 Kwangyong Park and Chul-Hee Cho 5. Fluorous Synthesis of 3-Aminoimidazo[1,2-a]-Pyridine/Pyrazine Library 51 Wei Zhang and Yimin Lu 6. Resin-to-Resin Transfer Reactions (RRTR) via Sonogashira Coupling 59 Judit Tulla-Puche, Rita S. Majerle, Fernando Albericio, and George Barany PART III IMMOBILIZED CATALYSTS AND LIGANDS 67 7. Polymer-supported Palladium Catalysts for Suzuki and Heck Reactions 69 Peter Styring 8. Solid-Phase Catalytic Activity of a Polymer-Supported Palladium Complex 79 Maria M. Dell'Anna, Piero Mastrorilli, and Cosimo F. Nobile 9. Polyaniline-immobilized Palladium for Suzuki-Miyaura Coupling Reaction in Water 87 Moumita Roy, Pravin R. Likhar, and M. Lakshmi Kantam 10. Synthesis of Polymer-Supported Aryldicyclohexylphosphine for an Efficient Recycling in Suzuki-Miyaura Reactions 91 Katarzyna Glegola and Eric Framery 11. C--C or C--N Reactions Catalyzed by Diadamanthylphosphine Palladium-Based Catalyst Supported on Dab-Dendrimers 97 Karine Heuze, Agnes Fougeret, Julietta Lemo, and Daniel Rosario-Amorin PART IV PALLADIUM-MEDIATED MULTIFUNCTIONAL CLEAVAGE 105 12. Solid-Phase Reactions of Resin-Supported Boronic Acids 107 Francois Carreaux, Bertrand Carboni, Herve Deleuze, and Christelle Pourbaix-L'Ebraly 13. A Simple Diversity Linker Strategy Using Immobilized Enol Phosphonates as Electrophiles for Suzuki-Miyaura Reactions 119 Tom M. Woods 14. Heck Cleavage of Resin-bound Triazenes 129 Sylvia Vanderheiden, Nicole Jung, and Stefan Brase 15. Pd-Mediated Cleavage from Tetrafluoroarylsulfonate Linker Units 139 Andrew N. Cammidge and Zainab Ngaini 16. Palladium-Catalyzed Solid-Phase Synthesis of Allylic Amines 145 Richard C. D. Brown and Martin L. Fisher 17. Palladium-Catalyzed Solid-Phase Synthesis of 4-Methylene Pyrrolidines 157 Lynda J. Brown, Richard C. D. Brown, and Martin L. Fisher Index 167

Produkt-Details

• Verlagsort: New York
• Sprache: englisch
• Maße: 152 x 229 mm
• Gewicht: 943 g
• Themenwelt: Naturwissenschaften ► Chemie
• ISBN-10: 1-118-33695-X / 111833695X
• ISBN-13: 978-1-118-33695-3 / 9781118336953
• Zustand: Neuware