Neuromodulators (eBook)

Ronald J. Bradley, R. Adron Harris, Peter Jenner, John Smythies (Herausgeber)

eBook Download: PDF

2005 | 1. Auflage
296 Seiten
Elsevier Science (Verlag)
978-0-08-046076-5 (ISBN)

Infos

Glutamate and GABA are the main information carrying neurotransmitters in the brain. Their action is modulated by a further series of small molecules called neuromodulators. The major neuromodulators in the brain are acetylcholine (both muscarinic and nicotinic), dopamine, norepinephrine, epinephrine and serotonin. These have an enormous range of functions in a wide variety of brain mechanisms. This book attempts to give a general overview of this field with a section devoted to each of these. Each section starts with anatomy, both structural and functional. The various types of receptors for these agents are described and then the effects of stimulating these receptors. These receptors trigger a variety of electrical reactions that generally involve potassium, sodium or calcium channels. Also reviewed are other receptors that trigger a wide variety of post-synaptic signaling cascades that influence a large number of neuronal functions including receptor sensitivity, synaptic plasticity and gene manipulation. Finally the relevance of these systems to disease states is detailed. There are many reviews of individual neuromodulators but this is the only book where one author attempts to cover the whole field.

Inhalt

front cover 1
copyright 5
table of contents 6
Preface 8
SECTION I THE CHOLINERGIC SYSTEM 9
PART I. INTRODUCTION 11
I. Anatomy 11
PART II. THE MUSCARINIC SYSTEM 12
I. Anatomy 12
II. Electrical Activity 16
III. Interactions with Other Transmitters 27
IV. Postsynaptic Cascades 32
V. Other Topics 37
PART III. THE NICOTINIC SYSTEM 63
I. Microanatomy 63
II. Functional Microanatomy 66
III. Interactions with Other Transmitters 69
IV. Learning 80
V. Miscellaneous Topics 85
Section I References 88
Section I Further Reading 125
SECTION II THE DOPAMINE SYSTEM 131
Section II Further Reading 178
Section II References 163
IX. Miscellaneous Items 163
VIII. Parkinson’s Disease 161
VII. Dopamine and Behavior 158
VI. Dopamine and Learning 156
V. Miscellaneous Items 151
IV. Dopamine-Induced Signaling Cascades 147
III. Interaction between Dopamine and other Transmitters 140
II. Electrical Reactions 137
I. Anatomy 132
SECTION III THE NOREPINEPHRINE SYSTEM 181
Section III Further Reading 219
Section III References 206
VIII. Miscellaneous Items 204
VII. Memory and Learning (LTP) 200
VI. Tropins and Cytokines 199
V. Postsynaptic Cascades 193
IV. Interactions with Other Transmitters 188
III. Electrical Activity 186
II. Functional Neuroanatomy 183
I. Microanatomy 182
SECTION IV THE ADRENALINE SYSTEM 220
Section IV References 221
SECTION V SEROTONIN SYSTEM 223
Section V Further Readings 273
Section V References 255
VIII. Miscellaneous 251
VII. Sleep 250
VI. Serotonin and the Development of Neural Systems 249
V. Serotonin and Synaptic Plasticity 244
IV. Postsynaptic Cascades 242
III. Interactions Between Serotonin and Other Neurotransmitter Systems 234
II. Electrical Actions 229
I. Anatomy 224
SECTION VI CONCLUSION 275
Section VI References 277
Possibly Obscure Acronyms for some Readers 278
index 279

Produkt-Details

• Erscheint lt. Verlag: 28.7.2005
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Humanbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• ISBN-10: 0-08-046076-3 / 0080460763
• ISBN-13: 978-0-08-046076-5 / 9780080460765