Gene Therapy Methods (eBook)

M. Ian Phillips (Herausgeber)

eBook Download: PDF

2002 | 1. Auflage
728 Seiten
Elsevier Science (Verlag)
978-0-08-049694-8 (ISBN)

Infos

This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated virus delivery for treatment of Parkinson's disease, are topical and are presented in the methods-oriented style popularized by this series.

This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated virus delivery for treatment of Parkinson's disease, are topical and are presented in the methods-oriented style popularized by this series.

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This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated virus delivery for treatment of Parkinson's disease, are topical and are presented in the methods-oriented style popularized by this series. - Discusses methods currently used in preclinical and clinical gene therapy- Covers the use of adeno-associated virus delivery for treatment of Parkinson's disease

Inhalt

Cover 1
Table of Contents 6
Contributors to Volume 346 12
Preface 20
Volumes in Series 22
Section I: Nonviral 42
Chapter 1. Gene Therapy for Hypertension: The Preclinical Data 44
Chapter 2. Oligonucleotide-Mediated Site-Directed Gene Repair 55
Chapter 3. Stabilized Plasmid-Lipid Particles: A Systemic Gene Therapy Vector 77
Chapter 4. Enhancing Direct in Vivo Transfection with Nuclease Inhibitors and Pulsed Electrical Fields 113
Chapter 5. Hydrodynamics-Based Transfection: Simple and Efficient Method for Introducing and Expressing Transgenes in Animals by Intravenous Injection of DNA 133
Chapter 6. Bioplex Technology: Novel Synthetic Gene Delivery System Based on Peptides Anchored to Nucleic Acids 147
Chapter 7. Surgical Procedures for Intravascular Delivery of Plasmid DNA to Organs 166
Chapter 8. Direct Gene Transfer into Mouse Heart 175
Section II: Adenovirus 184
Chapter 9. Myoblast-Mediated Gene Transfer for Therapeutic Angiogenesis 186
Chapter 10. Use of Phage Display to Identify Novel Peptides for Targeted Gene Therapy 198
Chapter 11. Helper-Dependent Adenoviral Vectors 218
Chapter 12. Gene Transfer Methods for Transplantation 240
Chapter 13. Generation and Growth of Gutted Adenoviral Vectors 265
Chapter 14. Adenovirus-Mediated Gene Transfer for Cardiovascular and Renal Diseases 288
Chapter 15. Gene Transfer to Blood Vessels Using Adenoviral Vectors 304
Chapter 16. Rearrangements in Adenoviral Genomes Mediated by Inverted Repeats 318
Chapter 17. High-Capacity, Helper-Dependent, GutlessŽ AdenoviralVectors for Gene Transfer into Brain 333
Chapter 18. Gene Therapy Methods in Cardiovascular Diseases 352
Section III: Adeno-Associated Virus 362
Chapter 19. Gene Delivery to Cardiac Muscle 364
Chapter 20. Recombinant AAV-Mediated Gene Delivery Using Dual Vector Heterodimerization 375
Chapter 21. Designing and Characterizing Hammerhead Ribozymes for Use in AAV Vector-Mediated Retinal Gene Therapies 399
Chapter 22. Adeno-Associated Viral Vector-Mediated Gene Therapy of Ischemia-Induced Neuronal Death 419
Chapter 23. Recombinant Adeno-Associated Viral Vector Production Using Stable Packaging and Producer Cell Lines 434
Chapter 24. Streamlined Large-Scale Production of Recombinant Adeno-Associated Virus (rAAV) Vectors 454
Section IV: Lentivirus 472
Chapter 25. Gene Transfer to the Brain Using Feline Immunodeficiency Virus-Based Lentivirus Vectors 474
Chapter 26. Generation of HIV-1 Derived Lentiviral Vectors 495
Chapter 27. Design, Production, Safety, Evaluation, and Clinical Applications of Nonprimate Lentiviral Vectors 507
Chapter 28. Gene Transfer to Airway Epithelia Using Feline Immunodeficiency Virus-Based Lentivirus Vectors 541
Chapter 29. Transduction of a Gene Expression Cassette Using Advanced Generation Lentiviral Vectors 555
Chapter 30. Construction, Purification, and Characterization of Adenovirus Vectors Expressing Apoptosis- Inducing Transgenes 570
Section V: Retrovirus 590
Chapter 31. Ligand-Inducible Transgene Regulation for Gene Therapy 592
Chapter 32. Large-Scale Production of Retroviral Vectors for Systemic Gene Delivery 603
Chapter 33. Oncoretroviral and Lentiviral Vector-Mediated Gene Therapy 614
Section VI: Other Strategies 632
Chapter 34. HSV-1 Amplicon Vectors 634
Chapter 35. Microencapsulation of Genetically Engineered Cells for Cancer Therapy 644
Chapter 36. HVJ (Hemagglutinating Virus of Japan Sendai Virus)-Liposome Method
Chapter 37. Gene Transfer with Foamy Virus Vectors 669
Chapter 38. Infectious Epstein–Barr Virus Vectors for Episomal Gene Therapy 690
Author Index 702
Subject Index 752

Produkt-Details

• Erscheint lt. Verlag: 6.3.2002
• Sprache: englisch
• Themenwelt: Naturwissenschaften ► Biologie ► Biochemie
• Themenwelt: Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
• Themenwelt: Technik
• ISBN-10: 0-08-049694-6 / 0080496946
• ISBN-13: 978-0-08-049694-8 / 9780080496948