Poly(ADP-Ribosyl)ation (eBook)

Alexander Burkle (Autor)

eBook Download: PDF

2008 | 2006
XVII, 246 Seiten
Springer US (Verlag)
978-0-387-36005-8 (ISBN)

Infos

This is the most comprehensive, up-to-date reference on this post-translational modification of proteins, which is intimately linked with DNA repair, maintenance of genomic stability, transcriptional regulation, cell death and a variety of other cellular phenomena as well as with a variety of pathophysiological conditions, including ischemia-reperfusion damage, Parkinson's disease, Type I diabetes mellitus, hemorrhagic and septic shock and other inflammatory conditions. Richly illustrated, it offers 19 chapters written by international experts.

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Poly(ADP-Ribosyl)ation comprises 19 chapters written by leading international experts in the field and is richly illustrated. Extensive bibliography is given in each chapter.

Inhalt

Contents 5
Editor 10
Preface 15
Chapter 1 Enzymes in Poly(ADP-Ribose) Metabolism 16
Chapter 2 PARP-2: Structure-Function Relationship 28
Chapter 3 Targeting the Poly(ADP-Ribose) Glycohydrolase (PARG) Gene in Mammals 47
Chapter 4 DNA Damage Signaling through Poly(ADP-Ribose) 56
Chapter 5 Roles of Poly(ADP-Ribose) Metabolism in the Regulation of Centrosome Duplication and in the Maintenance of Neuronal Integrity 66
Chapter 6 Functional Interactions of PARP-1 with p53 76
Chapter 7 Dynamic Interaction PCNA and p21 wafl/apl between PARP-1, 82
Chapter 8 PARP-1 as Novel Coactivator of NF-gB in Inflammatory Disorders 90
Chapter 9 PARP and Epigenetic Regulation 106
Chapter 10 PARP and the Release of Apoptosis-Inducing Factor from Mitochondria 118
Chapter 11 Genome Degradation by DNAS1L3 Endonuclease: A Key PARP-1-Regulated Event in optosis 133
Chapter 12 NAD: Metabolism and Regulatory Functions 147
Chapter 13 PARP-1 and the Shape of Cell Death 156
Chapter 14 P01y(ADP-Rib0se) Polymerase (PARP) and Excitotoxicity 168
Chapter 15 Poly(ADP-Ribose) Polymerase and Ischemia-Reperfusi0n Injury 179
Chapter 16 Role of Poly(ADP-Ribose) Polymerase Activation in the Pathogenesis of Inflammation and Circulatory Shock 199
Chapter 17 Role of Poly-ADP-Ribosylati0n in Cancer Development 218
Chapter 18 PARP Inhibitors and Cancer Therapy 233
Chapter 19 Poly(ADP-Ribosyl)ation and Aging 249
Index 257

Produkt-Details

• Erscheint lt. Verlag: 11.1.2008
• Reihe/Serie: Molecular Biology Intelligence Unit
• Zusatzinfo: XVII, 246 p.
• Verlagsort: New York
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Gesundheitsfachberufe
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin
• Themenwelt: Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie
• Themenwelt: Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
• Themenwelt: Naturwissenschaften ► Biologie
• Themenwelt: Technik
• Schlagworte: Activation • DNA • enzymes • genes • Metabolism • Post-translational modification • proteins • Regulation • transcription • Translation
• ISBN-10: 0-387-36005-0 / 0387360050
• ISBN-13: 978-0-387-36005-8 / 9780387360058