The Zebrafish: Disease Models and Chemical Screens

H. William Detrich III (Herausgeber)

Buch | Hardcover

616 Seiten

2011 | 3rd edition
Academic Press Inc (Verlag)
9780123813206 (ISBN)

Infos

Provides comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 2004. This volume covers two compelling applications of the zebrafish. It details the developments in zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls.

Autor

Professor of Biochemistry and Marine Biology at Northeastern University, promoted 1996. Joined Northeastern faculty in 1987. Previously a faculty member in Dept. of Biochemistry at the University of Mississippi Medical Center, 1983-1987.Principal Investigator in the U.S. Antarctic Program since 1984. Twelve field seasons "on the ice" since 1981. Research conducted at Palmer Station, Antarctica, and McMurdo Station, Antarctica.Research areas: Biochemical, cellular, and physiological adaptation to low and high temperatures. Structure and function of cytoplasmic microtubules and microtubule-dependent motors from cold-adapted Antarctic fishes. Regulation of tubulin and globin gene expression in zebrafish and Antarctic fishes. Role of microtubules in morphogenesis of the zebrafish embryo. Developmental hemapoiesis in zebrafish and Antarctic fishes. UV-induced DNA damage and repair in Antarctic marine organisms.

Inhalt

Part I: Disease Models
1. Germ Cell Tumors in Zebrafish
2. Schwann Cell Myelination Mutants as Models of Multiple Sclerosis
3. In Vivo Analysis of Zebrafish Adipogenesis
4. Host-Microbe Interactions in the Zebrafish
5. Hematopoietic Stem Cell Development and Blood Flow
6. Zebrafish as a Model for Hemorrhagic Stroke
7. Zebrafish Adaptive Immunity: Structure and Function of Physiologic Development and Malignant Transformation
8. Zebrafish VHL Disease Model
9. Muscle Diseases
10. Basement Membrane Diseases
11. Lymphangiogenesi
12. Osteogenesis
13. Zebrafish Assays of Ciliopathies
14. Infectious Disease: Innate Immunity
15. Tuberculosis
16. Cancer
17. Melanoma
18. Pancreatic Cancer
19. Rhabdomyosarcoma
20. Transplantation in Zebrafish
21. Modeling Human Disease by Gene Targeting
22. Fluorescent Imaging of Cancer
23. Zebrafish as a Model for Fanconi’s Anemia

Part II: Chemical Screens
24. Chemical Screens for Potential Therapeutics
25. Psychotropic Drug Discovery by Automated Behavioral Phenotyping
26. Discovery and Use of Small Molecules for Probing Biological Processes

Produkt-Details

• Erscheint lt. Verlag: 7.11.2011
• Reihe/Serie: Methods in Cell Biology
• Verlagsort: San Diego
• Sprache: englisch
• Maße: 184 x 260 mm
• Gewicht: 1620 g
• Themenwelt: Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zellbiologie
• Themenwelt: Naturwissenschaften ► Biologie ► Zoologie
• ISBN-13: 9780123813206 / 9780123813206
• Zustand: Neuware