Horizons in Neuroscience Research

Volume 1

Andres Costa, Eugenio Villalba (Herausgeber)

Buch | Hardcover

434 Seiten

2010
Nova Science Publishers Inc (Verlag)
978-1-60692-068-8 (ISBN)

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Neuroscience is the scientific study of the nervous system. The principle mechanism underlying enhanced pain sensitivity is a persistent hyperexcitability of spinal dorsal horn neurons. This book describes cellular mechanisms for the maintained hyperexcitability of spinal dorsal horn neurons mediated by neuron-glia interactions following spinal cord injury. In addition, nerve growth factor (NGF) has a key role not only in the development of sensory and autonomic neurons, but also in the processes of nociception. This book examines the recent evidence of the involvement of NGF in painful diseases and suggests the potential usefulness of anti-NGF strategies as novel analgesics for disabling pathological conditions. Furthermore, neuralgia is a symptom of some neurological disorders and can be found at any age. The pain that accompanies it is usually brief but may be severe. The authors present evidence sustaining the hypothesis that neuralgia (understood as being a shooting/shock-like paroxysmal pain) is a clinical expression of a transcriptional channelopathy. Other chapters in this book review the underlying mechanisms and the anatomical loci/shared circuits between epilepsy and memory, along with the relationship of various neurotransmitters involved. The morphological and functional characteristics of hereditary choroidal dystrophies are also examined, as well as the potential implications of neuroplasticity in dorsal vagal complex (DVC) in the adaptation of gastrointestinal functions.

Preface; Nervous, Immune, Endocrine Regulatory Systems & Diseases Associated with Nerve Growth Factor Co-Secretion ; Nerve Growth Factor & Pain: Evidence from Experimental Models & Humans, & New Prospectives for Treatment; Homeostatic Role of the Parasympathetic Nervous System in Human Behaviour ; LIMK1: The Key Enzyme of Actin Remodelling Bridges Spatial Organisation of Nucleus & Neural Transmission: From Heterochromatin via Non-Coding RNAs to Complex Behaviour; "Gliopathy" Maintains Persistent Hyperexcitability of Spinal Dorsal Horn Neurons after Spinal Cord Injury: Substrate of Central Neuropathic Pain; Multiple Neuronal & Glial Mechanisms Can be Involved in the Response to the Activation of Nicotinic Receptors; Calcium Signaling in Glial Cells of the Enteric Nervous System; Cocaine & Craving: From Normal Transmission to Pathological Functioning; Epilepsy & Cognitive Functions: An Inverse Relationship of the Underlying Mechanisms; Pathogenesis of Sciatica: Intraradicular Blood Flow Analysis under the Tension of Nerve Root Induced by Lumbar Disc Herniation; Hereditary Choroidal Dystrophies; Neuroplasticity in the Dorsal Vagal Complex; Vagus Nerve Stimulation in Food Intake Control; Amino Acid-Sensing by the Abdominal Vagus; Proteomics Helps to Elucidate the Causes of Schizophrenia; Is Neuralgia a Transcriptional Channelopathy?; Index.

Zusatzinfo	Illustrations
Verlagsort	New York
Sprache	englisch
Maße	260 x 180 mm
Gewicht	842 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
ISBN-10	1-60692-068-5 / 1606920685
ISBN-13	978-1-60692-068-8 / 9781606920688
Zustand	Neuware