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Visualizing Immunity

Dorian McGavern, Michael Dustin (Herausgeber)

Buch | Hardcover

XII, 292 Seiten

2009
Springer Berlin (Verlag)
978-3-540-93862-0 (ISBN)

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Researchers have used a variety of techniques over the past century to gain fun- mental insights in the field of immunology and, as technology has advanced, so too has the ability of researchers to delve deeper into the biological mechanics of immunity. The immune system is exceedingly complex and must patrol the entire body to protect us from foreign invaders. This requires the immune system to be highly mobile and adaptable - able to respond to diverse microbial challenges while maintaining the ability to distinguish self from a foreign invader. This latter feature is of great importance because the immune system is equipped with toxic mediators, and a failure in self/non-self discrimination can result in serious diseases. Fortunately, in most cases, the immune system operates within the framework of its elegant design and protects us from diverse microbial challenges without initiating disease. Because the immune system is not confined to a single tissue, a comprehensive understanding of immunity requires that research be conducted at the molecular, cellular, and systems level. Immune cells often find customized solutions to h- dling microbial insults that depend on the tissue(s) in which the pathogen is found.

Preface.- Two-photon imaging of the immune system: A custom technology platform for high-speed, multi-color tissue imaging of immune responses.- Visualizing intermolecular interactions in T cells.- Multiscale analysis of T cell activation: correlating in vitro and in vivo analysis of the immunological synapse.- T cell migration dynamics within lymph nodes during steady state: An overview of extracellular and intracellular factors influencing the basal intranodal T cell motility.- Chemoattractant Receptor Signaling and Its Role in Lymphocyte Motility and Trafficking.- New insights into leukocyte recruitment by intravital microscopy.- Visualizing the molecular and cellular events underlying the initiation of B cell activation.- Tracking the dynamics of salmonella specific T cell responses.- Multi-photon imaging of listeria monocytogenes infection.- Inflammation on the mind: Visualizing immunity in the central nervous system.- Multi-photon imaging of cytotoxic T lymphocyte-mediated anti-tumor immune responses.- Subject index.

Erscheint lt. Verlag	25.5.2009
Reihe/Serie	Current Topics in Microbiology and Immunology
Zusatzinfo	XII, 292 p. 31 illus., 25 illus. in color.
Verlagsort	Berlin
Sprache	englisch
Maße	155 x 235 mm
Gewicht	675 g
Themenwelt	Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie
Themenwelt	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
Schlagworte	anti-tumor T cells • basal intranodal T cell motility • B cell activation • Cells • central nervous system • chemoattract receptor signaling • immunity in the CNS • Infection • intermolecular interactions • leukocyte • leukocyte recruitment • Listeria monocytogenes infection • Listeria monocytogenes infection • Migration • Salmonella specific T cell responses • T Cell • T cell activation • tissue
ISBN-10	3-540-93862-1 / 3540938621
ISBN-13	978-3-540-93862-0 / 9783540938620
Zustand	Neuware