Roles of the Cerebellum in Motor Control

Foundations, Experimental Approaches and Clinical Applications

Mario Manto, Dagmar Timmann, Lena Clement (Herausgeber)

Buch | Softcover

275 Seiten

2026
Academic Press Inc (Verlag)
978-0-443-36404-4 (ISBN)

Noch nicht erschienen (ca. September 2026)
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Roles of the Cerebellum in Motor Control: Foundations, Experimental Approaches and Clinical Applications is a groundbreaking comprehensive reference of the intricate relationship between the cerebellum and motor function. Spanning five thorough sections, this book examines experimental approaches, from single neurons to networks, unraveling the mysteries of olivocerebellar somatotopy, motor prediction, and the cellular basis of motor learning. With chapters dedicated to neuroimaging, physiology, and pathophysiology, users will gain insight into the cerebellum's role in conditions such as tremor, dystonia, and Parkinson’s disease. From wearable sensors to digital gait biomarkers, various chapters offer a cutting-edge look at sensor technology and its application in assessing cerebellar function and rehabilitation. The book concludes with a discussion on research and clinical implications, providing a roadmap for translating laboratory findings into effective therapeutic strategies, making it an indispensable resource for researchers, clinicians, and students alike.

Dr. Mario Manto is a Neurologist at the Université Libre de Bruxelles (Belgium) with more than 20 years of experience in clinical neurology, particularly cerebellar ataxia. He is a Professor of Neuroanatomy at the University of Mons (Belgium) and Researcher at the FNRS (Belgium). He has been appointed Head of the Department of Neurology of the Centre Hospitalier Universitaire (CHU) de Charleroi (Belgium). The focus of his career for more than 20 years has been the study of cerebellar disorders, from a clinical and basic science point of view. He published more than 160 peer reviewed scientific articles and 15 book chapters on cerebellar topics and he is the editor of 6 books on cerebellar disorders. He is the Founding Editor and Editor in chief of two scientific journals: The Cerebellum and Cerebellum & Ataxias. He is Deputy Editor of the Journal of Neuroengineering and Rehabilitation and a Member of Faculty 1000. He has received many grants from several foundations including the NIH, European Commission, and the Fonds National de la Recherche Scientifique of Belgium. Dr. Timmann received her medical degree from the University of Tübingen, Germany. She is a board-certified neurologist. She was a postdoctoral researcher at the R.S. Dow Neurological Sciences Institute (Dr. F.B. Horak), Portland, USA, at the Arizona State University, Tempe and Barrow Neurological Institute (Dr. J. Bloedel), Phoenix, USA, and at the Dept. of Physiology (Dr. J. Hore), University of Western Ontario, London, Canada. She was a visiting scholar at the Human Sensorimotor Control Laboratory (Dr. J. Konczak), University of Minnesota, Minneapolis, MN, USA. Dr. Timmann’s research areas are the physiology and pathophysiology of the human cerebellum with a focus on human cerebellar lesion studies, lesion-behavior (“symptom)-mapping, ataxias, structural and functional MRI of the cerebellum and cerebellar nuclei. She is an Associate Professor of Experimental Neurology at the Department of Neurology, University Hospital Essen, University of Duisburg-Essen. Dr. Timmann is head of the Ataxia Clinic, Department of Neurology, University Hospital Essen. She is currently vice speaker of the Collaborative Research Center SFB 1280 “Extinction learning. Research Director INSERM, MSc quantum physics MSc molecular pharmacology, PhD Pasteur Institute, postdoc MIT

SECTION 1. Experimental approaches: from single neurons to networks
1. The olivocerebellar somatotopy
2. Cerebellum-brainstem loops
3. Fastigial nuclei: inputs/outputs
4. Complex spikes
5. Memory of motor learning
6. Motor prediction and feedback in Purkinje cell activity.
7. synchrony in cerebellar cortico-nuclear interactions
8. LTD
9. Predictive computations
10. Cellular imaging of cerebello-cerebral interactions
11. Intermodular integration in the cerebellar cortex for motor control
12. Cerebellar contribution to the development of sensorimotor circuits
13. Error processing in the cerebellar cortex
14. Mechanistic and Functional Diversity in Cerebello - Cerebral Coupling
15. Cerebellum-basal ganglia interactions

SECTION 2. From sensors to digital assessment of motion
16. digital gait biomarkers / wearables / cerebellar gait / rehab
17. Wearable sensors for upper limbs
18. Camera-based analysis
19. Gait
20. Machine learning

SECTION 3. Neuroimaging
21. Imaging of the motor cerebellum / circuits
22. Cerebellum and tremor: neuroimaging aspects
23. Functional connectivity
24. The cerebellar connectome
25. Structure-function relations in dystonia
26. Functional organization and perturbation of the cerebellum

SECTION 4. Physiology and pathophysiology of motion
27. Cerebellar control of timing and eye saccade
28. Cerebello-cerebral circuit in motor control and preparation
29. Sensorimotor integration of proprioception
30. Cerebellum in reaching movement
31. Cortico-cerebellar loops in reaching movement
32. timing behind motor control
33. Neurophysiology of cerebellar motor control in NHP
34. cerebellar control of locomotion
35. Occulomotor reflexes
36. Cerebellar cortico-nuclear interactions in eyeblink conditioning
37. Neurophysiology of cerebellum in tremor
38. Cerebellum and Parkinson’s disease

SECTION 5. Research and clinical implications: from the lab to the rehabilitation
39. Cerebellar dysfunction and rehabilitation
40. Cerebellar-based therapies of motor dysfunction
41. cerebellum and fatigue
42. non-invasive cerebellar stimulation / rehab
43. Cerebellar reserve

Erscheint lt. Verlag	1.9.2026
Verlagsort	San Diego
Sprache	englisch
Maße	191 x 235 mm
Gewicht	450 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
ISBN-10	0-443-36404-4 / 0443364044
ISBN-13	978-0-443-36404-4 / 9780443364044
Zustand	Neuware