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Practical Process Research and Development

A Guide for Organic Chemists

Neal G. Anderson (Autor)

Buch | Softcover

512 Seiten

2026 | 3rd edition
Academic Press Inc (Verlag)
978-0-443-36522-5 (ISBN)

Noch nicht erschienen (ca. August 2026)
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Practical Process Research and Development: A Guide for Organic Chemists, Third Edition provides a concise, comprehensive, step-by-step framework to support understanding and implement organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. The book describes the steps taken following synthesis and evaluation to bring key compounds to market in a cost-effective manner. Through a hands-on, step-by-step approach to solving process development problems, including route, reagent, and solvent selection, optimizing catalytic reactions, chiral syntheses, and green chemistry, this book helps organic, medicinal, pharmaceutical, and chemical process development chemists as well as chemical engineers with research and development initiatives.

In addition, it is well suited for beginners at upper undergraduate and graduate student level and early career researchers who need accessible insights into industrial process R&D.

Neal G. Anderson is a synthetic organic chemist with over 40 years of experience in chemical process R&D in the pharmaceutical industry. He earned a B.S. degree in biology from the University of Illinois and a Ph.D. in medicinal chemistry from the University of Michigan, followed by industrial post-doctoral studies at McNeil Laboratories. He has extensive hands-on experience in the laboratory, pilot plant, and in manufacturing facilities. At Squibb / Bristol-Myers Squibb he made key contributions to processes for the manufacture of four major drug substances, including captopril, and has participated in 12 manufacturing start-ups and introductions of many processes to pilot plants. He received a BMS President's Award and spot awards, and his final position was Principal Scientist. In 1997, Anderson established Anderson’s Process Solutions L.L.C., a consulting firm based in the USA to offer practical guidance on developing and implementing processes for bulk pharmaceuticals and fine chemicals. As part of these consulting services, he presents courses on selected aspects of practical process R&D. He is experienced in laboratory research, scale-up, and technology transfer to ensure reproducibility and optimal product quality.

1. Introduction
2. Safety Reactions
3. Route selection
4. Reagent selection
5. Solvent selection
6. Practical considerations for scale-up
7. In-process controls and reaction duration
8. Process optimization by minimizing impurities
9. Work-up conditions
10. Purification, crystallization and isolation
11. Final product form and impurities
12. Continuous operations
13. Scale-up concerns, validation, and process implementation
14. Trouble-shooting

Erscheint lt. Verlag	1.8.2026
Verlagsort	San Diego
Sprache	englisch
Maße	152 x 229 mm
Gewicht	450 g
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Naturwissenschaften ► Chemie ► Organische Chemie
	Naturwissenschaften ► Chemie ► Technische Chemie
	Technik
ISBN-10	0-443-36522-9 / 0443365229
ISBN-13	978-0-443-36522-5 / 9780443365225
Zustand	Neuware