Blombäck's Essential Guide to Blood Coagulation (eBook)

A Practical Guide to Diagnosis and Treatment of Hemostatic Disorders

Jovan P. Antovic, Maria Magnusson (Herausgeber)

eBook Download: EPUB

2025 | 3. Auflage
547 Seiten
Wiley (Verlag)
9781394223138 (ISBN)

Infos

New edition of a concise, comprehensive, easy-to-read pocket book distilling the most clinically up-to-date information on thrombotic and bleeding disorders

In a concise manner, Blombäck's Essential Guide to Blood Coagulation distills the most clinically up-to-date information on thrombotic and bleeding disorders, including the latest treatment strategies for key conditions and diseases. This book covers both the stable and the acute stages of hereditary and acquired bleeding and thrombotic disorders in adults, children, and geriatric patients. It also highlights the laboratory tests that can aid in diagnosing and identifying the cause of bleeding and/or thrombosis in a patient.

The book is organized into four main sections, each featuring numerous updates in this new edition. The first part introduces the reader to laboratory hemostasis and hemostasis physiology. The second part covers bleeding disorders, including a new chapter on bleeding disorders and aging. The third part discusses thromboembolic disorders, with a new chapter on extracorporeal membrane oxygenation (ECMO). The final section addresses special issues in hemostasis, with new chapters on hemostasis in renal disease, liver disorders, and cancer, as well as updated information on thrombotic thrombocytopenic purpura.

This edition of Blombäck's Essential Guide to Blood Coagulation also includes updates on:

• Hemostasis in COVID-19 and vaccine-induced thrombotic thrombocytopenia (VITT), a rare condition observed during pandemic
• Critical bleeding in different clinical situations and hemostasis in obstetrics and gynecology
• Platelet disorders, and rare coagulation factor deficiencies, cerebral vein and splanchnic vein thrombosis
• The greater paradigm shift in the treatment of hereditary bleeding disorders since the last edition was published
• Laboratory issues in hemostasis, including nomenclature and sampling
• Specific issues of hemostasis in children

Compact enough to fit into a coat pocket, Blombäck's Essential Guide to Blood Coagulation is a valuable guide for all those treating patients to expand their knowledge of hemostatic disorders. This text fills a void for the residents, fellow doctors, and practicing physicians who need rapid access to up-to-date information.

Jovan P. Antovic, MD, PhD, Professor in coagulation and clinical chemistry and Senior Consultant, Department of Clinical Chemistry, Karolinska University Hospital and Department of Molecular Medicine and Surgery, Coagulation Research, Karolinska Institutet, Stockholm, Sweden.

Maria Magnusson, MD, PhD, Head of the Department of Hematology and Senior Consultant in pediatric and adult coagulation, Karolinska University Hospital. Affiliated researcher, Department of Molecular Medicine & Surgery and Division of Pediatrics, Department of Clinical Science, Intervention & Technology, Karolinska Institutet.

---

New edition of a concise, comprehensive, easy-to-read pocket book distilling the most clinically up-to-date information on thrombotic and bleeding disorders In a concise manner, Blomb ck s Essential Guide to Blood Coagulation distills the most clinically up-to-date information on thrombotic and bleeding disorders, including the latest treatment strategies for key conditions and diseases. This book covers both the stable and the acute stages of hereditary and acquired bleeding and thrombotic disorders in adults, children, and geriatric patients. It also highlights the laboratory tests that can aid in diagnosing and identifying the cause of bleeding and/or thrombosis in a patient. The book is organized into four main sections, each featuring numerous updates in this new edition. The first part introduces the reader to laboratory hemostasis and hemostasis physiology. The second part covers bleeding disorders, including a new chapter on bleeding disorders and aging. The third part discusses thromboembolic disorders, with a new chapter on extracorporeal membrane oxygenation (ECMO). The final section addresses special issues in hemostasis, with new chapters on hemostasis in renal disease, liver disorders, and cancer, as well as updated information on thrombotic thrombocytopenic purpura. This edition of Blomb ck s Essential Guide to Blood Coagulation also includes updates on: Hemostasis in COVID-19 and vaccine-induced thrombotic thrombocytopenia (VITT), a rare condition observed during pandemicCritical bleeding in different clinical situations and hemostasis in obstetrics and gynecologyPlatelet disorders, and rare coagulation factor deficiencies, cerebral vein and splanchnic vein thrombosisThe greater paradigm shift in the treatment of hereditary bleeding disorders since the last edition was publishedLaboratory issues in hemostasis, including nomenclature and samplingSpecific issues of hemostasis in children Compact enough to fit into a coat pocket, Blomb ck s Essential Guide to Blood Coagulation is a valuable guide for all those treating patients to expand their knowledge of hemostatic disorders. This text fills a void for the residents, fellow doctors, and practicing physicians who need rapid access to up-to-date information.

Textauszug

Abbreviations

aCL

Cardiolipin antibodies

ACS

Acute coronary syndrome

ACT

Activated clotting time

ADAMTS‐13

A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13

ADP

Adenosine diphosphate

AF

Atrial fibrillation

AFLP

Acute fatty liver of pregnancy

AHA

Acquired hemophilia

AIS

Acute ischemic stroke

AKI

Acute kidney injury

ANCA

Antineutrophil cytoplasmic antibodies

APC

Activated protein C

aPL

Phospholipid antibodies

APS

Antiphospholipid syndrome

APTT

Activated partial thromboplastin time

ARDS

Acute respiratory distress syndrome

ART

Assisted reproductive technology

AS

Ankylosing spondylitis

ASA

Acetylsalicylic acid

ASCVD

Atherosclerotic cardiovascular disease

ASH

American Society of Hematology

ASPI

Aspirin test (Multiplate®)

ATLS

Advanced trauma life support

ATP

Adenosine triphosphate

AVK

Anti‐vitamin K

AVWD

Acquired von Willebrand disease

BAT

Bleeding assessment tool

BCS

Budd–Chiari syndrome

BDUC

Bleeding disorder of unknown cause

BMI

Body mass index

BSS

Bernard–Soulier syndrome

BHV

Bioprosthetic heart valve

BT

Bleeding time

CABG

Coronary artery by‐pass grafting

CAD

Coronary artery disease

CAPS

Catastrophic antiphospholipid syndrome

CAT

Cancer‐associated thrombosis

CBA

Collagen binding assay

CCS

Chronic coronary syndrome

CCT

Conventional coagulation tests

CFC

Coagulation factor concentrate

CKD

Chronic kidney disease

CLIA

Chemiluminescence immunoassay

CNS

Central nervous system

COC

Combined contraceptive pills

COX‐1

Cyclooxygenase‐1

CRP

C‐reactive protein

CSA

Chromogenic substrate assay

CT

Computed tomography

CTA

Computed tomography angiography

CTEPH

Chronic thromboembolic pulmonary hypertension

CTPA

Computed tomography pulmonary angiography

CVB

Chorionic villi biopsy

CVC

Central venous catheter

CVD

Cardiovascular disease

CVT

Cerebral venous thrombosis

DAPT

Dual antiplatelet therapy

DCI

Delayed cerebral ischemia

DDAVP

Deamino D‐arginine vasopressin

DIC

Disseminated intravascular coagulation

DOAC

Direct oral anticoagulants

DTI

Direct thrombin inhibitors

DVT

Deep venous thrombosis

ECCO2ER

Extracorporeal carbon dioxide removal

ECLS

Extracorporeal life support

ECMO

Extracorporeal membrane oxygenation

ECT

Ecarin clotting time

EDA

Epidural anesthesia

EDS

Ehlers–Danlos syndrome

EDTA

Ethylene‐diamine‐tetra‐acetic acid

eGFR

Estimated glomerular filtration rate

EHL

Extended half‐life

EMA

European Medicines Agency

EPCR

Endothelial protein C receptor

ERCP

Endoscopic retrograde cholangiopancreatography

ET

Essential thrombocytemia

ETP

Endogenous thrombin potential

FVIII

Factor VIII

FIX

Factor IX

FDP

Fibrin degradation products

FFP

Fresh frozen plasma

FM

Fibrin monomer

FPA

Fibrinopeptide A

GCA

Giant cell arteritis

GHA

Global hemostatic assays

GI

Gastrointestinal

GT

Glanzmann thrombasthenia

HALT

Hypoattenuated leaflet thickening

HCV

Hepatitis C virus

HDL

High‐density lipoprotein

HELLP

Hemolysis, elevated liver enzymes, low platelet counts

HHT

Hereditary hemorrhagic telangiectasia

HIPA

Heparin‐induced platelet aggregation

HIT

Heparin‐induced thrombocytopenia

HIV

Human immunodeficiency virus

HMB

Heavy menstrual bleeding

HRT

Hormone replacement therapy

HUS

Hemolytic uremic syndrome

ICH

Intracerebral hemorrhage

ICU

Intensive care unit

IFCC

International Federation of Clinical Chemistry and Laboratory Medicine

IHD

Ischemic heart disease

INR

International normalized ratio

IPF

Immature platelet fraction

IS

Ischemic stroke

ISI

International sensitivity index

ISTH

International Society on Thrombosis and Haemostasis

ITI

Immune tolerance induction

ITP

Imunne thrombocytopenia

IU

International unit

IUFD

Intrauterine fetal death

IUPAC

International Union of Pure and Applied Chemistry

IV

Intravenous

IVT

Intravenous thrombolysis

LA

Lupus anticoagulant

LAHPS

Lupus anticoagulant‐hypoprothrombinemia syndrome

LDA

Low‐dose aspirin

LDL

Low‐density lipoprotein

LMWH

Low molecular weight heparin

LTA

Light transmission aggregometry

MAP

Mean arterial pressure

MCFD2

Multiple coagulation factor deficiency genes

MGUS

Monoclonal gammopathy of unknown significance

MHV

Mechanical heart valve

MI

Myocardial infarction

MOF

Multiple organ failure

MPHV

Mechanical prosthetic heart valve

MPV

Mean platelet volume

MRA

Magnetic resonance angiography

MRI

Magnetic resonance imaging

MRT

Magnetic resonance tomography

MRV

Magnetic resonance venography

NETS

Neutrophil extracellular traps

NGS

Next‐generation sequencing

NHF

National Hemophilia Foundation

NHI

National Institute of Health

NOAC

New oral anticoagulant drug

NSAID

Nonsteroidal antiinflammatory drug

NSTEMI

Non ST‐elevation myocardial infarction

OAC

Oral anticoagulants

OC

Oral contraceptives

OCP

Overall coagulation potential

OFP

Overall fibrinolytic potential

OHP

Overall hemostatic potential

OHSS

Ovarian hyperstimulation syndrome

OSA

One‐stage assay

PAD

Peripheral artery disease

PAI‐1

Plasminogen activator inhibitor 1

PAP

Plasmin‐antiplasmin

PBAC

Pictorial blood loss assessment chart

PCC

Prothrombin‐complex concentrate

PCI

Percutaneous coronary intervention

PCR

Polymerase chain reaction

PDW

Platelet distribution width

PE

Pulmonary embolism

PF4

Platelet factor 4

PFT

Platelet function test

PGT

Preimplantation genetic testing

POCT

Point‐of‐care test

PRICE

Protection, Rest, Ice, Compression, and Elevation

Pro‐BNP

Pro B‐type natriuretic protein

PT

Prothrombin time

PTA

Percutaneous transluminal angioplasty

PTM

Platelet transmission electron microscopy

PTS

Post‐thrombotic syndrome

PVT

Portal vein thrombosis

QPD

Quebec platelet disorder

RA

Rheumatoid arthritis

RBC

Red blood cells

REBOA

Resuscitative endovascular balloon occlusion of the aorta

RIPA

Ristocetin‐induced platelet aggregation

ROTEM

Rotational thromboelastometry

rt‐PA

Recombinant tissue plasminogen activator

SAH

Subarachnoid hemorrhage

SAVR

Surgical aortic valve replacement

SC

Subcutaneous

SF

Soluble fibrin

SLE

Systemic lupus erythematosus

SpA

Spondylarthritis

SSc

Systemic sclerosis

SSC

Scientific and Standardization Committee

SSRI

Selective serotonin reuptake inhibitor

STEMI

ST‐elevation myocardial infarction

TAFI

Thrombin activatable fibrinolysis inhibitor

TAR

Thrombocytopenia with absent radius

TAT

Thrombin‐antithrombin

TAVI

Transcatheter valve implantation

TBI

Traumatic brain injury

TDM

Therapeutic drug monitoring

TEG

Thromboelastography

TF

Tissue factor

...

Produkt-Details

• Erscheint lt. Verlag: 3.9.2025
• Sprache: englisch
• Themenwelt: Medizin / Pharmazie ► Medizinische Fachgebiete ► Innere Medizin
• Schlagworte: acquired bleeding • acute bleeding • bleeding disorders, thrombotic treatment • laboratory hemostasis • stable bleeding • thrombotic diagnosis • thrombotic disorders • thrombotic tests • vaccine-induced thrombotic thrombocytopenia (VITT)
• ISBN-13: 9781394223138 / 9781394223138