Chronic myelomonocytic leukaemia (CMML)

Michaela Zahradnik (Autor)

Buch | Softcover

116 Seiten

2025
Our Knowledge Publishing (Verlag)
978-620-9-01378-2 (ISBN)

Titel nicht im Sortiment

Artikel merken

Chronic myelomonocytic leukaemia is a haematological neoplasm that develops as a result of clonal degeneration of haematopoietic stem cells. The first sign of the disease is an increase in the number of monocytes in the peripheral blood. In addition to cell proliferation, dysplastic haematopoiesis is also usually present. CMML is difficult to diagnose due to the heterogeneity of its clinical, haematological and morphological presentation and the absence of specific cytogenetic changes. In addition to distinguishing it from other haematological neoplasms, reactive monocytosis must be ruled out before a diagnosis can be made. Due to their immunological function, monocytes are increased in a variety of inflammatory and chronic processes as well as in tumour diseases. This research investigated whether flow cytometric analysis of CD56 expression on monocytes in the presence of absolute monocytosis in peripheral blood is suitable for distinguishing reactive cell proliferation from clonal processes. The study was conducted in collaboration with Andrea Hauser, MSc, and Dr Karl Schrattbauer.

Michaela ZAHRADNIK, MSc - Biomedical Analyst at the Clinical Institute for Laboratory Medicine at Vienna General Hospital until 2012, Master's degree in Biomedical Analysis, since 2013 lecturer at the University of Applied Sciences Campus Vienna in the Biomedical Analysis programme, Department of Haematology.

Erscheinungsdatum	26.08.2025
Sprache	englisch
Maße	152 x 229 mm
Gewicht	163 g
Themenwelt	Medizin / Pharmazie ► Allgemeines / Lexika
Themenwelt	Medizin / Pharmazie ► Gesundheitsfachberufe
Schlagworte	CD56 Expression • chronic myelomonocytic leukaemia • dysplasia • flow cytometric analysis • haematological neoplasms • haematopoietic stem cells • monocyte surface antigens • Monocytosis • myelodysplastic/myeloproliferative syndromes
ISBN-10	620-9-01378-3 / 6209013783
ISBN-13	978-620-9-01378-2 / 9786209013782
Zustand	Neuware